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Table 2 Trials on diuretics and/or β-blockers on which the recommendation of the JNC VI are based.

From: Generalizability of guidelines and physicians' adherence. Case study on the Sixth Joint National Commitee's guidelines on hypertension

  Eligibility criteria Exclusion criteria*
  Age (years) Gender Blood pressure** (mmHg) Myocardial infarction Stroke Heart failure Renal impairment
VA-NHBLI [36] 35 – 55 Males DBP: 85–105 Excluded Excluded Excluded Excluded
HDPF [37] 30 – 69 Both DBP ≥ 90 Included Included Included Included
Oslo [45] 40 – 50 Male SBP: 145–180 DBP<110 Excluded Excluded Excluded Excluded
Australia [43] 30 – 70 Both DBP: 95–110 SBP<200 Excluded Excluded Included Included
MRC [40] 35 – 64 Both DBP: 90–109 Included Included Included Included
VA I [34] < 70 Male DBP: 115–129 Included Included Included Included
VA II [35] < 70 Male DBP: 90–114 Included Included Included Included
PHS [44] < 55 Both DBP: 90–114 Excluded Excluded Excluded Excluded
HSCSG [33] < 75 Both SBP: 140–220 DBP: 90–115 Included Included Included Excluded
Barraclough [32] 56 – 69 Both DBP: 100–120 Included Included Included Included
Carter [38] < 80 Both BP≥ 160/110 Included Must have one in the previous 3 months Excluded Excluded
EWPHE [39] ≥ 60 Both DBP: 90–119 SBP: 160–239 Included Included Excluded Excluded
Coope [42] 60 – 79 Both DBP≥ 105 SBP≥ 170 Excluded Excluded Excluded Excluded
MRC – O [29] 65 – 75 Both DBP<115 SBP: 160–209 Included Included Excluded Excluded
SHEP [41] ≥ 60 Both DBP<90 SBP: 160–219 Excluded Excluded Excluded Excluded
STOP [30] 70 – 84 Both DBP: 90–120 SBP: 180–130 Included Included Included Included
  1. * We considered only these exclusion criteria because they are the most important factors influencing the base line risk in hypertensive people ** SPB: Systolic Blood Pressure; DBP: Diastolic Blood Pressure