Table 1 Clinical features of published case reports of adverse effects from mefloquine, and their possible relation to liver and thyroid pathology
| Â | Prophylaxis case reports (N = 328) | Treatment case reports (N = 188) |
|---|---|---|
Number (%) of reports very likely liver related | 75/328(23) | 85/188(45) |
Number (%) of reports plausibly but debatably liver related | 102/328 (31) | 29/188 (15) |
Number (%) of reports plausibly thyroid related | 51/328 (16) | 26/188 (14) |
Probably unrelated to liver or thyroid | 100/328 (30) | 48/188 (26) |
Median dose (range) of mefloquine taken (mg) | 750 (250–8750) | 1250 (150–5250) |
Median duration (range) of adverse effects (days) | 16 (1–550) | 4 (1–300) |