Figure 2
Examples of the evolution of a pathogen’s niche in space and time and how it can be manipulated for control. (Left ) Illustration of fluctuations in the number of susceptible and infectious individuals with time and an example of optimized pathogen control combining pulsed vaccination of susceptible hosts and timely treatment of infectious ones. (Right) The host geographic structure can be used and manipulated to stop a pathogen spill-over by restricting opportunities for migration between transmission hotspots where resources (i.e., susceptible hosts) are plentiful.