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Table 4 Risk factors for HBeAg positivity in HBsAg-positive children (3 rd generation)

From: The association between maternal hepatitis B e antigen status, as a proxy for perinatal transmission, and the risk of hepatitis B e antigenaemia in Gambian children

Variables Prevalence of HBeAg (+) Crude odds ratios Adjusted odds ratios2,3
   OR 95% CI P OR 95% CI P
Maternal HBsAg (2nd generation)        
Negative 83.3% (5/6) 1.0   0.5 1.0   0.5
Positive 65.4% (34/52) 0.4 0.1-4.2   0.4 0.1-5.3  
Maternal HBeAg (2nd generation)        
Negative 60.0% (12/20) 1.0   0.5 1.0   0.04
Positive 71.1% (27/38) 1.6 0.4-6.1   4.5 1.0-19.5  
No of older siblings with positive HBsAg        
0 65.6% (21/32) 1.0   0.71 1.0   0.91
1 66.7% (10/15) 1.0 0.3-3.8   1.1 0.2-7.2  
≥2 72.7% (8/11) 1.4 0.3-6.4   1.2 0.0-47.5  
No. of older siblings with positive HBeAg        
0 64.1% (25/39) 1.0   0.41 1.0   0.81
1 69.2% (9/13) 1.3 0.3-4.9   1.1 0.3-4.9  
≥2 83.3% (5/6) 2.8 0.3-27.7   2.0 0.1-42.7  
  1. 1Linear test for trend.
  2. 2Model included maternal HBsAg, maternal HBeAg, number of older siblings with HBsAg, number of older siblings with HBeAg, year of birth, and total sibship size.
  3. 3Wald test from generalised estimating equations.