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Table 1 Cross sectional and cohort studies on Ferritin level and of the Metabolic Syndrome

From: Ferritin levels and risk of metabolic syndrome: meta-analysis of observational studies

First author Year (Reference number) Country Study design Population Men (%) Age years Sample Ferritin assay Metabolic syndrome criteria Ferritin concentration (μg/l) *Quality score
Men Women
Jehn, 2004 [11] U.S. Cross-sectional NHANES III (1988–1994) U.S. Population 48 48 5,949 RIA NCEP ATPIII Q1:62a Q4:318a Premenopausal: Q1:11a Q4:89a Postmenopausal: Q1:35a Q4:212a 30
Bozzini, 2005 [12] Italy Cross-sectional Verona Heart Project 73 58 479 NIA NCEP ATPII Both genders: With MS: 124 (111–138)b Without MS: 83 (73–94)b 19
Choi, 2005 [13] Korea Cross-sectional Welfare Centers of Seoul Metropolitan 0 72 959 EIA NCEP original   With MS: 74 ± 2c Without MS: 59 ± 2c 28
Soto González 2006 [14] Spain Cross-sectional Patients of the Endocrinoloy and Nutrition Service of Hospital 34 38 598 RIA NCEP ATPIII Both genders: With MS: 133.9 ± 141.1d Without MS: 66.8 ± 71.8d 31
Vari, 2007 [32] France Prospective cohort DESIR cohort French people 6 years of follow up 49 47 944 NIA NCEP ATPIII At baseline 178 ± 90d At baseline Premenopausal women: 56 ± 40d Postmenopausal women: 92 ± 54d 32
Shi, 2008 [15] China Cross-sectional The 2002 National Nutrition and Health survey 46 40-49 2,816 RIS NR Q4:257 (176–500)e Q4:170 (96–504)e 30
Sun, 2008 [16] China Cross-sectional Nutrition and Health of Aging population 44 58 3,165 TIA NCEP ATPIII Q1:71 (68–73.2)b Q4:327 (316–340)b Q1:52 (51–54)b Q4:231(224–239)b 30
Ryu, 2008 [17] Korea Cross-sectional Korean Rural GENOMIC Cohort 38 58 1,444 N.R NCEP ATPIII Q1:45 ± 2f Q4:258 ± 12f Q1:17 ± 2f Q4:131 ± 1f 32
Kim, 2011 [18] Korea Cross-sectional Healthy volunteers 53 51 7,253 TIA NCEP ATPIII 176 ± 108d 75 ± 55d 30
Park, 2012 [26] Korea Prospective cohort Check-up of men in Health Promotion Center 100 44 13,084   International Diabetes Federation At baseline 112 ± 64d ------------- 31
Kang, 2012 [20] Korea Cross-sectional South Korean general population KNANHES IV (2007–2008) 44 48 7,346 RIA NCEP ATPIII Q1:46 (33, 55)g Q4:194(167, 247)g Q1:13 [9, 17]g Q4:90 (75, 114)g 27
Hämäläinen, 2012 [21] Finland Case–control People invited to heath check up in 2004 45 52 766 EIA NCEP ATPIII With MS: 216 ± 165d Without MS: 151 ± 112d With MS: 94 ± 75d Without MS: 61 ± 48d 28
Leiva, 2013 [19] Chile Cross-sectional Research program of Risk Factors for Cardiovascular Disease of Talca 31 57 155 EIA NCEP ATPIII With MS: 72 (47–112)h Without MS: 55 (36–96)h With MS: 54 (34–85)h Without MS: 27 (13–60)h 30
Chang, 2013 [22] Taiwan Cross-sectional Third national nutritional and health survey in Taiwan (NAHSIT 2005-2008) 43 55 2,654 EIA NCEP ATPIII modified 229 ± 349d 119 ± 180d 27
Li, 2013 [31] China Cross-sectional China Health and Nutrition Survey 47 51 8,441 RIA NCEP ATPIII modified Q1:52a Q4:423a Q1:12.9a Q4:142.7a 30
  1. EIA, Electrochemiluminescence immunoassay; NIA, Nephelometric immunoassay; NR, not reported; RIA, immunoradiometric assay; TIA, immunoturbidimetric assay. *Quality score of STROBE Statement.
  2. aMedian of quartile; bGeometric mean (95% CI); cGeometric mean ± SD; dMean ± SD; eMean of quartile (minimum-maximum); fGeometric mean ± SE; gMedian (range); hGeometric mean (range).
  3. SD: standard deviation; SE: standard error; CI: confidence interval; MS: metabolic syndrome; Q1: quartile 1; Q4: quartile 4: T1: tertile 1; T3: tertile 3.