Annual cost reduction | Key parameters and/or change(s) in key parameters |
---|---|
$12.7 billion | Base case |
$1.1 billion | No change in fiber intake for 75% of adults; 25% of adults increase fiber intake by 3Â g daily |
$13.2 billion | Assumes that 1% of men and women currently meet fiber intake recommendation |
$12.0 billion | Assumes that 10% of men and women currently meet fiber intake recommendation |
$7.5 billion | Assumes that 50% of adults with constipation respond to fiber increase |
$4.8 billion | Assumes that 25% of adults with constipation require a prescription; 75% take over-the counter products |
$20.0 billion | Assumes that 1Â g of increased fiber intake is associated with a 3% reduction in constipation |
$19.3 billion | Assumes that 7% of the adult population has constipation |
$2.8 billion | Assumes that 1% of the adult population has constipation |
$19.5 billion | Assumes that 4.0% of men and 10.2% of women have constipation {Markland, 2013 #632} |
$21.9 billion | Assumes that adults increase fiber intake by 15Â g daily |
$0.7 billion | Pediatric population only; assumes 100% of the population increased fiber intake by 6Â g daily |
$83.9 billion | Multivariate: best case - Assumes that 1% of adults meet fiber intake recommendations, 7% of adults have constipation, 1Â g of fiber intake is associated with a 3% reduction in constipation, all patients require a prescription medication, 100% of adults increase fiber intake (by 15Â g daily) |
$2.3 million | Multivariate: worst case - Assumes that 10% of adults meet fiber intake recommendations, 1% of adults have constipation, 1Â g of fiber intake is associated with a 1% reduction in constipation, all patients are treated with an over the counter medication, only 25% of adults increase fiber intake (by 3Â g daily) |