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Table 1 Design and baseline characteristic of trials included in the systematic review and meta-analysis

From: Effect of omega-3 fatty acid supplementation on cancer incidence, non-vascular death, and total mortality: a meta-analysis of randomized controlled trials

Source No. of patients Mean age, y Sex (male, %) Disease status Intervention Control Follow-up (months) Reporting outcomes Jaded score
Borchgrevink CF (1966) [7] 100/100 57.4 100 Coronary heart disease 10 ml linseed oil 10 ml corn oil 10 Cancer incidence; nonvascular death; total death 2
Burr ML (1989) [8] 1015/1018 56.5 100 Recovered from myocardial infarction Fish dietary Non-fish dietary 24 Cancer incidence; Nonvascular death; total death 1
de Lorgeril M (1994) [28] 302/303 53.5 90.8 Myocardial infarction within 6 months Alpha-linolenic acid rich diet Post-infarct prudent diet 27 Nonvascular death; total death 1
Rossing P (1996) [9] 18/18 33.0 65.5 Diabetic nephropathy N–3 fatty acids Olive oil 12 Cancer incidence; 4
Leng GC (1998) [29] 60/60 65.7 68.3 Stable intermittent claudication Gamma-linolenic and eicosapentaenoic acids Placebo 24 Nonvascular death; total death 3
von Schacky (1999) [10] 111/112 58.4 80.3 Coronary artery disease Fish oil concentrate (55% eicosapentaenoic and docosahexaenoic acids) Placebo 24 Cancer incidence; 5
GISSI-Prevenzione Investigators (1999) [11] 5666/5658 60.0 85.3 Recovered from myocardial infarction N-3 polyunsaturated fatty acids witho or without vitamin E Vitamin E or no treatment 42 Cancer incidence; Nonvascular death; total death 3
Nilsen DWT (2001) [12] 150/150 64.0 79.4 Acute myocardial infarction 4 g highly concentrated n-3 fatty acids Corn oil 24 Cancer incidence; nonvascular death; total death 2
Burr ML (2003) [13] 1571/1543 61.1 100 Angina Two portions of oily fish each week, or to take three fish oil capsule daily with or without more fruit, vegetables and oats no specific dietary advice with or without more fruit, vegetables and oats 60 Cancer incidence; nonvascular death; total death 3
Raitt MH (2005) [14] 100/100 62.5 86 Implantable cardioverter defibrillator and a recent episode of sustained VT or VF Fish oil, 1.8 g/d, 72% omega-3 PUFAs Placebo 24 Cancer incidence; nonvascular death; total death 4
Leaf A (2005) [30] 200/202 65.5 83.1 Implantable cardioverter defibrillator Fish oil Olive oil 12 Nonvascular death; total death 3
Brouwer IA (2006) [15] 273/273 61.5 84.5 Implantable cardioverter defibrillator 2 g/d of fish oil Placebo 12 Cancer incidence; nonvascular death; total death 4
JELIS Ivestigators (2007) [16] 9326/9319 61.0 31.5 Total cholesterol of 6 · 5 mmol/L or greater EPA with statin Statin 55.2 Cancer incidence; nonvascular death; total death 5
GISSI-HF investigators (2008) [31] 3494/3481 67.0 NG Chronic heart failure N-3 PUFA 1 g daily Placebo 46.8 Nonvascular death; total death 5
OMEGA Study Group (2010) [32] 1919/1885 64.0 74.4 Recovered from myocardial infarction 1 g omega-3 acid ethyl esters-90 Olive oil 12 Nonvascular death; total death 4
Einvik G (2010) [33] 282/281 70.1 100 Hypercholesterolemia (> 6.45 mmol/l) 2.4 g n-3 PUFA Corn oil 36 Nonvascular death; total death 4
SU.FOL.OM3 Collaborative Group (2010) [17] 1253/1248 60.6 79.4 with a history of myocardial infarction, unstable angina, or ischaemic stroke Omega 3 fatty acids with or without vitamin B Placebo or vitamin B 56.4 Cancer incidence; total death 5
Alpha Omega Trial Group (2010) [34] 2404/2433 69.0 78.2 Recovered from myocardial infarction EPA and DHA with or without ALA ALA or placebo 40.8 Nonvascular death; total death 4
The ORIGIN Trial Investigators (2012) [35] 6281/6255 63.5 65.1 High risk for cardiovascular events N–3 fatty acids Placebo 74.4 Nonvascular death; total death 4