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Table 1 MHO definition; cohort studies

From: Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review

Study

Definition of metabolically healthy obese (MHO)

Definition of metabolically healthy, normal weight (MHNW)

Katzmarzyk [19]

• <3 MetS

• ≤ 2 MetS criteria, normal weight (BMI 18.5-24.9 kg/m2)

• BMI ≥30 kg/m2

• Diabetics included

St-Pierre [17]

• ≤2 insulin resistance syndromeA (IRS) criteria

• ≤2 IRSA criteria, normal weight (BMI <25 kg/m2)

• BMI ≥ 30 kg/m2

• Diabetics excluded

Meigs [14]

• < 3 MetS criteria and/or IS by HOMA-IR < 75th percentile

• <3 MetS criteria, normal weight (BMI < 25 kg/m2) and/or IS, normal weight (BMI < 25 kg/m2)

• BMI ≥ 30 kg/m2

• Diabetics excluded

Daly [20]

• <3 MetSB

• <3 MetSB , normal weight (BMI <25 kg/m2)

• BMI > 30 kg/m2

• Diabetics included

Song [21]

• < 3 MetSC criteria

• <3 MetSC , normal weight (BMI <25 kg/m2)

• BMI ≥30 kg/m2

• Diabetics included

Kuk [13]

• ≤1 MetS criteria and/or IS by HOMA < 2.5

• ≤1 MetS criteria, normal weight (BMI < 25 kg/m2) and/or IS, normal weight (BMI < 25 kg/m2)

• BMI ≥ 30 kg/m2

• Diabetics included

Arnlov [9]

• <3 MetSD criteria and/or IS by HOMA-IR <75th percentile

• <3 MetSD criteria, normal weight (BMI < 25 kg/m2) and/or IS, normal weight (BMI < 25 kg/m2)

• BMI > 30 kg/m2

• Diabetics excluded

Calori [10]

•IS by HOMA-IR < 2.5

• IS, not obese (BMI < 30 kg/m2)

• BMI ≥ 30 kg/m2

• Diabetics included

Voulgari [18]

• < 3 MetS criteria

• <3 MetS criteria, normal weight (BMI <24.9 kg/m2)

• BMI ≥ 30 kg/m2

• Diabetics excluded

Hosseinpanah [12]

• <3 MetSE criteria

• <3 MetSE criteria, normal weight (BMI 18.5-24.9 kg/m2)

• BMI ≥30 kg/m2

• Diabetics included

Bobbioni-Harsch [23]

• 0 MetS criteria

• 0 MetS criteria, normal weight (BMI < 25 kg/m2)

• BMI ≥25 kg/m2

Ogorodnikova [15]

• ≤ 2 MetSC criteria; ≤1 of any MetSC criteria, IR by HOMA-IR > 75th percentile of all participants, or systemic inflammation by WBC >75th percentile for all participants; or IS by HOMA-IR ≤25th percentile among non-diabetic obese, sex-specific

• ≤ 2 MetSC criteria, normal weight (BMI 18.5-24.9 kg/m2) or ≤ 1 MetSC criteria, IR by HOMA-IR > 75th percentile of all participants, or systemic inflammation by WBC >75th percentile for all participants, normal weight (BMI 18.5-24.9 kg/m2) or IS, normal weight (BMI 18.5-24.9 kg/m2)

• BMI ≥ 30 kg/m2

• Diabetics included

Hamer [11]

• <2 MetSF criteria (including CRP ≥3.0 mg/L)

• <2 MetSF criteria, not obese (BMI 18–29.9 kg/m2) or <2 MetSF criteria, normal waist (≤102 cm in men, ≤88 cm in women)

• BMI ≥30 kg/m2 or waist circumference >102 cm men, >88 cm women

• Diabetics included

Bo [22]

• < IS by HOMA < 2.5 AND <3 MetSG criteria

• IS, normal weight (BMI <25 kg/m2)

• BMI > 30 kg/m2

• Diabetics included

Ortega [16]

• ≤1 MetSC criteria

• ≤1 MetSC criteria, normal weight (BMI 18.5-24.9 kg/m2) or • ≤1 MetSC criteria, normal body fat (<25% men/<30% women)

• Body Fat% ≥ 25/30 (M/F) ORBMI ≥ 30 kg/m2

• Diabetics included

  1. A TG ≥150 mg/dL, HDL <50 mg/dL, ≥54.5% of LDL particles with diameter <255A, Apo lipoprotein B level ≥1.36 g/L, fasting insulin level ≥ 85.2 pmol/L, blood pressure ≥ 135/85 mmHg, CRP ≥3.0 mg/L; B TG and waist circumference excluded, added BMI > 30 kg/m2 into criteria; C Waist circumference excluded; D Waist circumference excluded, added BMI ≥ 29.4 kg/m2 cut-point into criteria; E Waist circumference ≥89 cm for men and ≥91 cm for women, blood pressure ≥ 140/85 mmHg; F TG excluded, added CRP ≥ 3 mg/L into criteria; G Waist circumference ≥94 cm for men and ≥80 cm for women, fasting plasma glucose ≥ 100 mg/dl or use of hypoglycemic therapy.
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BMC Public Health

ISSN: 1471-2458

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