Figure 2

Flowchart of study design. Children are enroled at age 12–36 months with routine follow up visits (shown in blue bars) every 6 months. During enrolment and routine follow up visits, a stool sample, blood sample and nasopharyngeal swab (NPS) will be collected in addition to a case report form detailing growth and health information. Follow up will continue for a total of two years for each child, meaning they will exit the cohort at 36–60 months of age. Parents will be contacted on a regular basis to enquire whether their child has experience diarrhoeal disease. When the child experiences an episode of diarrhoea (shown in red bars), study nurses can travel to the home of the participant to a stool sample and a short case report form or the family can bring the child to the Hospital for Tropical Disease for clinical examination. Stool will be collected during diarrhoeal episodes.