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Table 2 Outcome variables organized by chronic sequelae for studies relating to Campylobacter published prior to July 2011

From: Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae

First author, year, reference number Species Sequelae negative prior to diagnosis with Campylobacter? Time from Campylobacterdiagnosis to evaluation for chronic sequelae (Days) Diagnosis of Campylobacter Diagnosis of sequelae Number of people with Campylobacter Number developing sequelae Outcome
ReA         
Ternhag, [52] spp. NR 365 NR Physician/medical records^ 57425 15 0.03%
Schoenberg-Norio, [51] jejuni NR 60 Confirmed+ Physician/medical records 201 8 3.98%
Townes, [47] NR All were disease negative 42 Confirmed Combination 2384 33 1.38%
Kosunen, [39] jejuni All were disease negative 365 Confirmed Physician/medical records 342 8 2.34%
Petersen, [27] mix NR NR Confirmed Physician/medical records 41 0 0%
Short, [25] jejuni NR 240 Confirmed Physician/medical records 15 0 0%
Hannu, [43] mix All were disease negative 60 Confirmed Physician/medical records 609 45 7.39%
Hannu, [43] mix All were disease negative 60 Confirmed Combination 609 52 8.54%
Hannu, [43] jejuni All were disease negative 60 Confirmed Specialist 535 37 6.92%
Hannu, [43] coli All were disease negative 60 Confirmed Specialist 61 8 13.11%
Hannu, [43] Undetermined All were disease negative 60 Confirmed Specialist 13 0 0%
Melby, [32] jejuni NR 42 Probable Self-reported disease status 159 1 0.63%
Pitkanen, [23] jejuni NR NR Confirmed Self-reported disease status 56 3 5.36%
Locht, [37] mix All were disease negative 28 Confirmed Self-reported disease status 173 27 15.61%
Schiellerup, [41] NR No – excluded~ 60 Confirmed Self-reported based on validated scale 1003 131 13.06%
Hannu, [54] jejuni All were disease negative 90 Probable Specialist 350 9 2.57%
Pitkänen, [29] jejuni All were disease negative NR Confirmed Combination 188 9 4.79%
Helms, [38] NR All were disease negative 365 Confirmed Physician/medical records 17991 22 0.12%
Ponka, [40] jejuni NR NR Confirmed Self-reported disease status 283 6 2.12%
Doorduyn, [44] NR NR 1080 Confirmed Self-reported disease status 434 20 4.61%
Eastmond, [35] jejuni All were disease negative 90 Confirmed Physician/medical records 88 1 1.14%
Eastmond [35] jejuni All were disease negative 90 Confirmed Physician/medical records 42 0 0%
Melby, [55] mix NR NR Probable Self-reported disease status 77 2 2.60%
Gumpel, [49] NR NR NR Confirmed Physician/medical records 33 8 24.24%
Bremell, [33] NR NR 24 Confirmed Self-reported disease status 66 1 1.52%
Reiter’s         
Kosunen, [39] jejuni All were disease negative Up to 365 Confirmed NR 342 1 0.29%
Doorduyn, [44] NR NR 1080 Confirmed Self-reported disease status 457 0 0%
IBS         
Ternhag, [52] spp NR 365 NR Physician/medical records 57425 15 0.03%
Spence, [31] spp All were disease negative 180 Confirmed Self-reported based on validated scale 620 49 7.90%
Thornley, [46] spp. All were disease negative 180 Confirmed Self-reported based on validated scale 188 17 9.04%
Spiller, [30] NR NR 365 Confirmed Self-reported based on validated scale 31 4 12.90%
Helms, [38] NR All were disease negative 365 Confirmed Physician/medical records 17991 161 0.89%
Doorduyn. [44] NR No – included 1080 Confirmed Self-reported disease status 457 12 2.63%
Saps, [28] NR NR 180 Confirmed Self-reported 6 1 16.67%
Dunlop, [42] jejuni/coli All were disease negative 90 Confirmed Self-reported based on validated scale 747 103 13.79%
Moss-Morris, [45] NR All were disease negative 90 Confirmed Self-reported based on validated scale 775 83 10.71%
Moss-Morris, [45] NR All were disease negative 180 Confirmed Self-reported based on validated scale 748 59 7.89%
IBD         
Helms, [38] NR All were disease negative 365 Culture Physician/Medical records 17991 72 0.40%
UC         
Ternhag, [52] spp. NR 365 NR Physician/Medical records 57425 42 0.07%
Jess, [48] NR All were disease negative Up to 16 years Confirmed Physician/Medical records 49420 223 0.45%
Crohn’s         
Ternhag, [52] spp. NR 365 NR Physician/Medical records 57425 27, 83 0.05%, 0.17%
Jess, [48]   All were disease negative Up to 16 years Confirmed Physician/Medical records 49420 83 0.17%
GBS         
Ternhag, [52] spp. NR 90 NR Physician/medical records 57425 13 0.02%
Gardner, [34] jejuni All were disease negative NR Probable Physician/medical records 98 1 1.02%
McCarthy, [36] jejuni No – excluded 180 Probable Physician/medical records 8086 0 0%
Wang, [24] coli NR NR Confirmed Physician/medical records 24 0 0%
Wang, [24] jejuni NR NR Confirmed Physician/medical records 80 0 0%
Wang [24] mix NR NR Confirmed Physician/medical records 104 0 0%
McCarthy, [53] NR All were disease negative 180 Confirmed Physician/medical records 29563 9 0.03%
Helms, [38] NR All were disease negative 365 Confirmed Physician/medical records 17991 6 0.03%
Tam, [50] NR All were disease negative 60 NR Physician/medical records 15587 3 0.02%
Doorduyn, [44] NR NR 1080 Confirmed Physician/medical records 457 0 0%
MF         
Doorduyn, [44] NR NR 1080 Confirmed Self-reported disease status 457 0 0%
HUS         
Ternhag, [52] spp. NR 90 NR Physician/Medical records 57425 2 0%
Helms, [38] NR All were disease negative 90 Confirmed Physician/Medical records 17991 1 0.01%
Rowe, [26] NR All were disease negative NR Confirmed Physician/Medical records 72 0 0%
  1. NR = Not Reported.
  2. ^Medical Records/Physician includes those hospitalized for sequelae or diagnosed by a physician.
  3. + Confirmed for Campylobacter are those confirmed by culture, DNA based tests or serology. Probable cases were based on case definition given in study.
  4. ~No – excluded; Campylobacter cases with previous medical history of related sequelae were excluded from analysis. No-included; Campylobacter cases with previous medical history of related sequelae were not excluded from analysis.