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Table 2 Outcome variables organized by chronic sequelae for studies relating to Campylobacter published prior to July 2011

From: Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae

First author, year, reference number

Species

Sequelae negative prior to diagnosis with Campylobacter?

Time from Campylobacterdiagnosis to evaluation for chronic sequelae (Days)

Diagnosis of Campylobacter

Diagnosis of sequelae

Number of people with Campylobacter

Number developing sequelae

Outcome

ReA

        

Ternhag, [52]

spp.

NR

365

NR

Physician/medical records^

57425

15

0.03%

Schoenberg-Norio, [51]

jejuni

NR

60

Confirmed+

Physician/medical records

201

8

3.98%

Townes, [47]

NR

All were disease negative

42

Confirmed

Combination

2384

33

1.38%

Kosunen, [39]

jejuni

All were disease negative

365

Confirmed

Physician/medical records

342

8

2.34%

Petersen, [27]

mix

NR

NR

Confirmed

Physician/medical records

41

0

0%

Short, [25]

jejuni

NR

240

Confirmed

Physician/medical records

15

0

0%

Hannu, [43]

mix

All were disease negative

60

Confirmed

Physician/medical records

609

45

7.39%

Hannu, [43]

mix

All were disease negative

60

Confirmed

Combination

609

52

8.54%

Hannu, [43]

jejuni

All were disease negative

60

Confirmed

Specialist

535

37

6.92%

Hannu, [43]

coli

All were disease negative

60

Confirmed

Specialist

61

8

13.11%

Hannu, [43]

Undetermined

All were disease negative

60

Confirmed

Specialist

13

0

0%

Melby, [32]

jejuni

NR

42

Probable

Self-reported disease status

159

1

0.63%

Pitkanen, [23]

jejuni

NR

NR

Confirmed

Self-reported disease status

56

3

5.36%

Locht, [37]

mix

All were disease negative

28

Confirmed

Self-reported disease status

173

27

15.61%

Schiellerup, [41]

NR

No – excluded~

60

Confirmed

Self-reported based on validated scale

1003

131

13.06%

Hannu, [54]

jejuni

All were disease negative

90

Probable

Specialist

350

9

2.57%

Pitkänen, [29]

jejuni

All were disease negative

NR

Confirmed

Combination

188

9

4.79%

Helms, [38]

NR

All were disease negative

365

Confirmed

Physician/medical records

17991

22

0.12%

Ponka, [40]

jejuni

NR

NR

Confirmed

Self-reported disease status

283

6

2.12%

Doorduyn, [44]

NR

NR

1080

Confirmed

Self-reported disease status

434

20

4.61%

Eastmond, [35]

jejuni

All were disease negative

90

Confirmed

Physician/medical records

88

1

1.14%

Eastmond [35]

jejuni

All were disease negative

90

Confirmed

Physician/medical records

42

0

0%

Melby, [55]

mix

NR

NR

Probable

Self-reported disease status

77

2

2.60%

Gumpel, [49]

NR

NR

NR

Confirmed

Physician/medical records

33

8

24.24%

Bremell, [33]

NR

NR

24

Confirmed

Self-reported disease status

66

1

1.52%

Reiter’s

        

Kosunen, [39]

jejuni

All were disease negative

Up to 365

Confirmed

NR

342

1

0.29%

Doorduyn, [44]

NR

NR

1080

Confirmed

Self-reported disease status

457

0

0%

IBS

        

Ternhag, [52]

spp

NR

365

NR

Physician/medical records

57425

15

0.03%

Spence, [31]

spp

All were disease negative

180

Confirmed

Self-reported based on validated scale

620

49

7.90%

Thornley, [46]

spp.

All were disease negative

180

Confirmed

Self-reported based on validated scale

188

17

9.04%

Spiller, [30]

NR

NR

365

Confirmed

Self-reported based on validated scale

31

4

12.90%

Helms, [38]

NR

All were disease negative

365

Confirmed

Physician/medical records

17991

161

0.89%

Doorduyn. [44]

NR

No – included

1080

Confirmed

Self-reported disease status

457

12

2.63%

Saps, [28]

NR

NR

180

Confirmed

Self-reported

6

1

16.67%

Dunlop, [42]

jejuni/coli

All were disease negative

90

Confirmed

Self-reported based on validated scale

747

103

13.79%

Moss-Morris, [45]

NR

All were disease negative

90

Confirmed

Self-reported based on validated scale

775

83

10.71%

Moss-Morris, [45]

NR

All were disease negative

180

Confirmed

Self-reported based on validated scale

748

59

7.89%

IBD

        

Helms, [38]

NR

All were disease negative

365

Culture

Physician/Medical records

17991

72

0.40%

UC

        

Ternhag, [52]

spp.

NR

365

NR

Physician/Medical records

57425

42

0.07%

Jess, [48]

NR

All were disease negative

Up to 16 years

Confirmed

Physician/Medical records

49420

223

0.45%

Crohn’s

        

Ternhag, [52]

spp.

NR

365

NR

Physician/Medical records

57425

27, 83

0.05%, 0.17%

Jess, [48]

 

All were disease negative

Up to 16 years

Confirmed

Physician/Medical records

49420

83

0.17%

GBS

        

Ternhag, [52]

spp.

NR

90

NR

Physician/medical records

57425

13

0.02%

Gardner, [34]

jejuni

All were disease negative

NR

Probable

Physician/medical records

98

1

1.02%

McCarthy, [36]

jejuni

No – excluded

180

Probable

Physician/medical records

8086

0

0%

Wang, [24]

coli

NR

NR

Confirmed

Physician/medical records

24

0

0%

Wang, [24]

jejuni

NR

NR

Confirmed

Physician/medical records

80

0

0%

Wang [24]

mix

NR

NR

Confirmed

Physician/medical records

104

0

0%

McCarthy, [53]

NR

All were disease negative

180

Confirmed

Physician/medical records

29563

9

0.03%

Helms, [38]

NR

All were disease negative

365

Confirmed

Physician/medical records

17991

6

0.03%

Tam, [50]

NR

All were disease negative

60

NR

Physician/medical records

15587

3

0.02%

Doorduyn, [44]

NR

NR

1080

Confirmed

Physician/medical records

457

0

0%

MF

        

Doorduyn, [44]

NR

NR

1080

Confirmed

Self-reported disease status

457

0

0%

HUS

        

Ternhag, [52]

spp.

NR

90

NR

Physician/Medical records

57425

2

0%

Helms, [38]

NR

All were disease negative

90

Confirmed

Physician/Medical records

17991

1

0.01%

Rowe, [26]

NR

All were disease negative

NR

Confirmed

Physician/Medical records

72

0

0%

  1. NR = Not Reported.
  2. ^Medical Records/Physician includes those hospitalized for sequelae or diagnosed by a physician.
  3. + Confirmed for Campylobacter are those confirmed by culture, DNA based tests or serology. Probable cases were based on case definition given in study.
  4. ~No – excluded; Campylobacter cases with previous medical history of related sequelae were excluded from analysis. No-included; Campylobacter cases with previous medical history of related sequelae were not excluded from analysis.