Association between physical and mental health-related quality of life and adverse outcomes; a retrospective cohort study of 5,272 Scottish adults

Table 2 Cox regression models of the association between quintiles of physical component summary score (PCS) of the SF-12 and adverse outcomes

	Model 1		Model 2		Model 3
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
All-cause death
PCS quintile
1 (worst)	4.23 (2.70, 6.63)	<0.001	2.64 (1.66, 4.20)	<0.001	2.81 (1.76, 4.49)	<0.001
2	1.97 (1.22, 3.19)	0.005	1.44 (0.88, 2.34)	0.146	1.55 (0.95, 2.54)	0.078
3	1.45 (0.86, 2.42)	0.160	1.09 (0.65, 1.84)	0.747	1.15 (0.68, 1.94)	0.599
4	1.06 (0.61, 1.84)	0.826	0.90 (0.52, 1.57)	0.718	0.95 (0.55, 1.66)	0.869
5 (best)	1.00	-	1.00	-	1.00	-
Cancer registration
PCS quintile
1 (worst)	1.87 (1.29, 2.71)	0.001	1.60 (1.08, 2.37)	0.018	1.63 (1.10, 2.42)	0.015
2	1.58 (1.07, 2.31)	0.020	1.45 (0.98, 2.14)	0.067	1.47 (0.99, 2.19)	0.056
3	1.39 (0.93, 2.07)	0.110	1.29 (0.86, 1.93)	0.223	1.30 (0.86, 1.95)	0.212
4	1.50 (1.01, 2.23)	0.043	1.46 (0.98, 2.18)	0.062	1.45 (0.98, 2.17)	0.066
5 (best)	1.00	-	1.00	-	1.00	-
Coronary heart disease hospitalisation/death
PCS quintile
1 (worst)	2.57 (1.35, 4.93)	0.004	1.99 (1.01, 3.93)	0.047	1.99 (1.00, 3.96)	0.049
2	2.23 (1.15, 4.30)	0.017	1.82 (0.93, 3.59)	0.082	1.81 (0.92, 3.58)	0.087
3	1.61 (0.79, 3.25)	0.187	1.36 (0.67, 2.78)	0.398	1.36 (0.66, 2.78)	0.402
4	1.36 (0.66, 2.80)	0.405	1.19 (0.57, 2.47)	0.646	1.19 (0.57, 2.48)	0.640
5 (best)	1.00	-	1.00	-	1.00	-

Higher quintile indicate better physical health status; PCS, physical component summary quintile (score): 1 (<42), 2 (42 to 50.9), 3 (51 to 54.9), 4 (55 to 56), 5 (>56); HR, hazard ratio; CI, Confidence interval; Model 1 adjusted for age; Model 2 adjusted for age, sex, SIMD, education level, smoking status, alcohol consumption, hypertension and diabetes; Model 3 adjusted for same covariates as Model 2 plus body mass index.

ISSN: 1471-2458