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Table 2 Predictors of one year of follow-up virological and immunological failure by univariate logistic regression

From: Pharmacy refill adherence outperforms self-reported methods in predicting HIV therapy outcome in resource-limited settings

 

Virological failure

Immunological failure

 

> 400 copies/ml

> 1,000 copies/ml

Predictor

OR (95% CI)

p-value

OR (95% CI)

p-value

OR ( 95% CI)

p-value

Age per 1 year older

1 (0.96 - 1.03)

0.8

0.97 (0.93 - 1.02)

0.24

0.92 (0.85 - 0.98)

0.02

Being able to recall diagnosis date

0.39 (0.2 - 0.75)

0.01

0.3 (0.14 - 0.63)

<0.01

0.31(0.1 - 0.87)

0.03

Being on nevirapine regimen

2.17 (1.06 - 4.64)

0.04

2.76 (1.18 - 7.28)

0.03

1.3 (0.46 - 4.28)

0.64

Being on efavirenz regimen

0.48 (0.22 - 0.98)

0.05

0.37 (0.14 - 0.88)

0.03

0.79 (0.24 - 2.27)

0.68

Being on stavudine regimen

1.99 (1.03 - 3.89)

0.04

2.23 (1.06 - 4.83)

0.04

1.71 (0.62 - 4.94)

0.3

Body mass index per unit

1.06 (1.01 - 1.12)

0.03

1.02 (0.96 - 1.07)

0.53

0.97 (0.87 - 1.05)

0.5

Weight per 1 kg higher

1.03 (1 - 1.06)

0.03

1.02 (0.99 - 1.05)

0.13

0.99 (0.95 - 1.03)

0.65

Having baseline CD4 T lymphocytes count < 200 cell/μl

1.47 (0.7 - 3.03)

0.3

2.9 (1.32 - 6.35)

0.01

2.9 (1.02 - 8.17)

0.04

Therapy duration

8.67 (1.47 - 66.9)

0.02

8.75 (1.35 - 80.87)

0.03

2 (0.2 - 19.79)

0.53

Being on triomune regimen

2.07 (1.07 - 4.04)

0.03

2.31 (1.1 - 5)

0.03

1.76 (0.64 - 5.08)

0.28

Undetectable viral load at baseline

0.46 (0.21 - 1.01)

0.05

0.29 (0.13 - 0.68)

<0.01

0.23 (0.08 - 0.68)

0.01

Ever having drug holidays

3.32 (1.06 - 11.29)

0.04

5.2 (1.56 - 18.4)

0.01

2.46 (0.54 - 10.72)

0.23

SHCS-AQ adherence

0.83 (0.41 - 1.72)

0.61

0.78 (0.36 - 1.76)

0.54

0.7 (0.25 - 2.14)

0.51

VAS adherence (>95%)

0.65 (0.25 - 1.68)

0.36

0.54 (0.2 - 1.53)

0.22

0.21 (0.07 - 0.69)

0.01

Appointment adherence >80%)

0.68 (0.31 - 1.5)

0.33

0.65 (0.28 - 1.57)

0.32

1.28 (0.39 - 5.8)

0.71

Pharmacy refill adherence (>95%)

0.41 (0.21 - 0.8)

0.01

0.26 (0.12 - 0.57)

<0.01

1.23 (0.45 - 3.55)

0.69

Pill count adherence (>90%)

1.86 (0.62 - 5.5)

0.26

1.9 (0.56 - 5.78)

0.27

0.66 (0.04 - 3.7)

0.7

  1. Key: SHCS-AQ = Swiss HIV Cohort study Adherence questionnaire; VAS = Visual analog scale; OR = odds ratio; CI = confidence interval.
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BMC Public Health

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