Table 2 Top 10 generated rules for smokers prescribed varenicline & NOT prescribed varenicline (exposure group size > =500)

1.1

alcohol = NO, heavy smoker = YES, obesity = NO, dementia = NO, depression/anxiety = NO, epilepsy = NO, hypertension = NO, psychotic disorders = NO, age = 31-45, gender = female

14.9

2.1

psychotic disorders = YES, age > 60, sex = female

99.7

1.2

alcohol = NO, heavy smoker = YES, obesity = NO, depression/anxiety = NO, epilepsy = NO, hypertension = NO, psychotic disorders = NO, age = 31-45, gender = female

14.8

2.2

COPD = NO, psychotic disorders = YES, age > 60, gender = female

99.6

1.3

alcohol = NO, heavy smoker = YES, obesity = NO, dementia = NO, depression/anxiety = NO, epilepsy = NO, hypertension = NO, psychotic disorders = NO, age = 31-45

14.0

2.3

alcohol = YES, psychotic disorders = YES

99.6

1.4

alcohol = NO, heavy smoker = YES, obesity = NO, depression/anxiety = NO, epilepsy = NO, hypertension = NO, psychotic disorders = NO, age = 31-45

14.0

2.4

psychotic disorders = YES, age > 60

99.5

1.5

alcohol = NO, heavy smoker = YES, obesity = NO, dementia = NO, depression/anxiety = NO, hypertension = NO, psychotic disorders = NO, age = 31-45

13.9

2.5

heavy smoker = NO, COPD = NO, dementia = YES, age > 60

99.5

1.6

alcohol = NO, heavy smoker = YES, obesity = NO, depression/anxiety = NO, hypertension = NO, psychotic disorders = NO, age = 31-45

13.8

2.6

heavy smoker = NO, psychotic disorders = YES, age > 60

99.4

1.7

alcohol = NO, heavy smoker = YES, obesity = NO, dementia = NO, depression/anxiety = NO, epilepsy = NO, hypertension = NO, psychotic disorders = NO, age = 31-45, gender = male

13.5

2.7

COPD = NO, psychotic disorders = YES, age > 60

99.4

1.8

alcohol = NO, heavy smoker = YES, obesity = NO, depression/anxiety = NO, epilepsy = NO, hypertension = NO, psychotic disorders = NO, age = 31-45, gender = male

13.4

2.8

heavy smoker = NO, dementia = YES, depression/anxiety = NO, age > 60

99.4

1.9

alcohol = NO, heavy smoker = YES, obesity = NO, asthma = YES, CKD = 0, COPD = YES, dementia = NO, epilepsy = NO, hypertension = NO, learning disability = NO, psychotic disorders = NO, age = 46-60

13.4

2.9

heavy smoker = NO, COPD = NO, psychotic disorders = YES, age > 60

99.3

1.10

alcohol = NO, heavy smoker = YES, obesity = NO, COPD = YES, dementia = NO, depression/anxiety = NO, epilepsy = NO, hypertension = NO, psychotic disorders = NO, age = 46-60

13.3

2.10

heavy smoker = NO, psychotic disorders = YES, age = 31-45, gender = male

99.3