Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men

BMC Public Health

Table 4 Hazard ratios for cancer mortality by body mass index and cardiorespiratory fitness at baseline, according to follow-up period

Variable	N	Man-years	No. of cancer deaths	Age adjusted hazard ratio	Multivariable hazard ratio
				(95%CI)	(95%CI)
< 10 yr of follow-up (n = 8,760)
BMI
1st tertile (18.5-21.5 kg · m^-2)	2,846	29,323	12	1.47 (0.62 - 3.49)	1.50 (0.50 - 4.51)
2nd tertile (21.6-23.6 kg · m^-2)	2,956	28,162	9	1.00 (Reference)	1.00 (Reference)^a
3rd tertile (23.7-37.4 kg · m^-2)	2,958	29,342	14	1.43 (0.62 - 3.30)	1.33 (0.41 - 4.36)
P for trend				0.983	0.598
Cardiorespiratory fitness
1st tertile (Lowest)	2,819	27,905	18	1.00 (Reference)	1.00 (Reference)^b
2nd tertile	3,020	29,959	11	0.59 (0.28 - 1.26)	0.55 (0.25 - 1.18)
3rd tertile (Highest)	2,921	28,962	6	0.37 (0.15 - 0.93)	0.35 (0.13 - 0.92)
P for trend				0.026	0.024
≥ 10 yr of follow-up (n = 8,523)
BMI
1st tertile (18.5-21.5 kg · m^-2)	2,883	56,531	50	1.21 (0.81 - 1.80)	1.20 (0.80 - 1.79)
2nd tertile (21.6-23.6 kg · m^-2)	2,758	59,378	47	1.00 (Reference)	1.00 (Reference)^a
3rd tertile (23.7-37.4 kg · m^-2)	2,882	59,231	46	0.90 (0.60 - 1.35)	0.86 (0.57 - 1.30)
P for trend				0.154	0.123
Cardiorespiratory fitness
1st tertile (Lowest)	2,733	55,914	54	1.00 (Reference)	1.00 (Reference)^b
2nd tertile	2,943	60,703	53	0.93 (0.63 - 1.35)	0.86 (0.58 - 1.26)
3rd tertile (Highest)	2,847	58,522	36	0.72 (0.47 - 1.10)	0.67 (0.43 - 1.04)
P for trend				0.139	0.077

BMI, body mass index.
^a Adjusted for age, cardiorespiratory fitness, systolic blood pressure, cigarette smoking, and alcohol intake.
^b Adjusted for age, BMI, systolic blood pressure, cigarette smoking, and alcohol intake.

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