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Table 1 Characteristics of included studies

From: The effect of antiemetics in childhood gastroenteritis

Author Year of publication Country Period of Intervention Target population Antiemetic Route of administration Dose and Frequency Duration of Follow up Study design
Uhlig [19] 2009 Germany December 2005 to May 2007 Children 6 months to 6 years with suspected infectious gastroenteritis (<24 hours) with mild or no dehydration, 2 vomiting in 12 hours, > 7kg Dimenhydrinate Rectal Suppositories <15kg 40mg, 15 to 25 kg 80mg, >25kg 120 mg 18-24 hours after randomization, and 7-14 days after randomization Double Blind, Prospective, Randomized, Placebo control, Multicenter
Freedman [13] 2006 USA January 2004 to April 2005 Children 6 months to 10 years with vomiting or dehydration as a result of AGE and at least one episode of nonbilious vomiting, and no severe dehydration Ondansetron Oral 8-15kg 2mg, 15-30kg 4mg, >30kg 8mg day 3 and day 7 via telephone, last follow-up till max of 2 weeks Double Blind, Prospective Placebo
Ramsook [15] 2002 USA   Children 6 months to 12 years with clinically diagnosed AGE with 5 episodes of vomits in 24 hours Ondansetron Oral 6 months to 1 year 1.6mg, 1 year to 3 years 3.2mg, 4 to 12 years 4mg 24 and 48 hours Double Blind, Prospective
Roslund [17] 2008 USA July 1, 2004, to August 1, 2005 Children 1 to 10 years with AGE and mild to moderate dehydration who failed controlled oral challenge in ED Ondansetron Oral <15kg 2mg, 15 to 23 kg 4mg, >30kg 6 mg 1 week Double Blind, Prospective
Stork [20] 2006 USA November 1999 and February 2005 Children aged 6 months to 12 years, with more than three episodes of vomiting in the past 24 hours, mild/moderate dehydration, and failed oral hydration. Children with a history or physical examination findings inconsistent with the diagnosis of isolated acute viral gastritis were excluded Ondansetron or dexamethasone with IVF IV dexamethasone 1 mg/kg (15 mg maximum), ondansetron 0.15 mg/kg 2 hour follow-ups up to 48 hours Double Blind, Prospective
Yilmaz [18] 2010 Turkey August 2003 and September 2004 Children aged 5 months to 8 years who had nonbillious, nonbloody vomit at least 4 times in the last 6 hours, who could not tolerate ORT, at least four episodes of diarrhea in the previous 24 hours, and who had mild-to-moderate dehydration. Aetiology of acute gastroenteritis (viral, bacterial or amebic) was not taken into account in the patients included in the study. Ondansetron Oral ondansetron 0.2 mg/ kg 8 hourly 24 hours Double blind, Prospective
Cubeddu [12] 1997 Venezuela   6 months to 8 years with spontaneous vomiting with in 1 hour and no severe dehydration Ondansetron, metoclopramide IV ondansetron 0.3 mg/kg single dose, metoclopramide 0.3 mg/kg single dose 24 hours Double Blind, Prospective, parallel group, placebo