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Table 2 Quality assessment by outcome

From: Emollient therapy for preterm newborn infants – evidence from the developing world

  Quality assessment Summary of findings
  Directness No of events*  
No of studies Design Limitations Consistency Generalizability to population of interest Generalizability to intervention of interest Intervention Control RR / SMD (95% CI)
Neonatal mortality: moderate outcome specific quality of evidence
Three RCT No significant heterogeneity, fixed effect model used One of the three studies suggest benefit All studies from the developing countries Two of the studies used sunflower while one used coconut oil as emollient 04 11 RR: 0.73 [0.56, 0.94]
Hospital acquired infection: moderate outcome specific quality of evidence
Three RCT No significant heterogeneity, fixed effect model used All studies suggest benefit All studies from the developing countries Studies used sunflower and coconut oil 19 33 RR: 0.50 [0.36, 0.71]
Weight: moderate outcome specific quality of evidence
Four studies (five data sets) RCT No significant heterogeneity, fixed effect model used Three studies suggest benefit All studies from the developing countries Studies used coconut, sunflower and soybean oil 149 151 SMD: 98.04 [42.64, 153.45]
Weight gain (g/kg/day): moderate outcome specific quality of evidence
Two studies (three data sets) RCT Significant heterogeneity so a random effect model used One study suggested benefit All studies from developing countries Studies used coconut and sunflower oil 95 97 SMD: 1.57 [0.79, 2.36]
Length: moderate outcome specific quality of evidence
Two studies (three data sets) RCT Significant heterogeneity so a random effect model used Two studies suggest benefit All studies from developing countries Studies used coconut and sunflower oil 124 128 SMD: 0.33 [-0.15, 0.81]
Head circumference: moderate outcome specific quality of evidence
Two studies (three data sets) RCT No significant heterogeneity, fixed effect model used None of the studies suggest benefit All studies from developing countries Studies used coconut and sunflower oil 124 128 SMD: 0.05 [-0.30, 0.41]