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Table 1 Characteristics of the included studies

From: Emollient therapy for preterm newborn infants – evidence from the developing world

Author Country Target population Emollient Dose and frequency Follow up
Arora 2005 [14] India Neonates <37 weeks and <1500 g Sunflower oil 4 times a day (10ml/kg/day) 28 days
Darmstadt 2004 [20] Egypt Neonates <34 weeks and <72hr old. Gestational age was determined with an average of gestational age values by last menstrual period, per the criteria of Ballard and Dubowitz Sunflower oil 3 times a day for 14 days and then 2 times a day (12g/kg/day) 28 days
Darmstadt 2005 [11] Bangladesh Neonates <33 weeks and <72hr old. Gestational age was identified by doctors, according to the methods described by Dubowitz and Ballard, and on the basis of maternal dates (time from the first day of the last menstrual period); the average of the three measures was used A. Sunflower seed oil
B. Aquaphor
3 times a day for 14 days and then 2 times a day (12g/kg/day) 28 days or until discharge if <28 days
Darmstadt 2008 [21] Bangladesh Neonates <33 weeks and <72hr old. Gestational age was identified by doctors, according to the methods described by Dubowitz and Ballard, and on the basis of maternal dates (time from the first day of the last menstrual period); the average of the three measures was used A. Sunflower seed oil
B. Aquaphor
3 times a day for 14 days and then 2 times a day (12g/kg/day) 28 days or until discharge if <28 days
Kumar 2012 [24] India Neonates <35 weeks and <1800 g Sunflower oil 10ml/kg/day 28 days
Salam (Unpublished) [25] Pakistan Neonates ≥26 weeks and ≤37 weeks with a birth weight >750g. Gestational age estimated from ultrasound records and Ballard scores at admission Coconut oil 2 times a day (10 ml/kg/day) 28 days
Sankaranarayanan 2005 [22] India Preterm (1500 to 2000g) and term (>2500g) A. Coconut oil
B. Mineral oil
4 times a day 31 days
Soriano 2000 [23] Brazil Neonates 28-34 weeks and <1700 g Soybean oil 3 times a day (12g/kg/day) 30 days