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Table 1 Severe acute malnutrition: quality assessment of evidence at the category level

From: Treatment of severe and moderate acute malnutrition in low- and middle-income settings: a systematic review, meta-analysis and Delphi process

  QUALITY ASSESSMENT SUMMARY OF FINDINGS
Number of studies Design Limitations Consistency Generalizability to population of interest Events in intervention group Events in control group Effect size (95% CI)
Mortality: Moderate outcome specific quality Risk Ratio
3 quasi-experimental 1 moderate/low, 2 moderate/high quality studies Inconsistent direction of effect, I2 = 0 Children 10-60 months presenting to nutrition rehabilitation units in Malawi 25 15 0.77 (0.40, 1.50)
Recovery rate: Low outcome specific quality Risk Ratio
3 quasi-experimental 1 moderate/low, 2 moderate/high quality studies Consistent direction of effect to varying degree, I2 = 92% Children 10-60 months presenting to nutrition rehabilitation units in Malawi 148 155 1.51 (1.04, 2.20)
Rate of height gain: Moderate/low outcome specific quality Mean Difference
3 quasi-experimental 1 moderate/low, 2 moderate/high quality studies Inconsistent direction of effect, I2 = 40% Children 10-60 months presenting to nutrition rehabilitation units in Malawi N/A N/A 0.14 (0.05, 0.22)
Rate of MUAC gain: Moderate/low outcome specific quality Mean Difference
3 quasi-experimental 1 moderate/low, 2 moderate/high quality studies Inconsistent direction of effect, I2 = 0 Children 10-60 months presenting to nutrition rehabilitation units in Malawi N/A N/A 0.11 (0.05, 0.18)
Rate of weight gain (RUTF vs. standard care): Moderate outcome specific quality Mean Difference
3 quasi-experimental 1 moderate/low, 2 moderate/high quality studies Consistent direction of effect to varying degree, I2 = 49% Children 10-60 months presenting to nutrition rehabilitation units in Malawi N/A N/A 1.27 (0.16, 2.38)
Rate of weight gain (imported vs. locally-produced RUTF): Moderate/low outcome specific quality Mean Difference
2 quasi-experimental, RCT 1 moderate/high and 1 low quality study Consistent direction of effect, I2 = 0% Children 6-60 months presenting to feeding clinics, studies in Malawi and Senegal N/A N/A 0.53 (-0.57 to 1.63)