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Table 2 Quality Assessment by Hematologic Outcome

From: Effectiveness of Micronutrient Powders (MNP) in women and children

  Quality Assessment Summary of Findings
  Directness No of events  
No of studies Design Limitations Consistency Generalizability to population of interest Generalizability to intervention of interest Intervention Control RR / SMD (95% CI)
Anemia: Moderate outcome specific quality of evidence
Eleven RCT Significant heterogeneity, random effect model used Six of ten studies suggest benefit All studies from the developing countries The duration of the studies ranged from 2-12 months and the age of the children from 6 months to 10 years. 1081 1443 RR: 0.66 [0.57, 0.77]
Iron deficiency Anemia: Moderate outcome specific quality of evidence
Seven studies (six data sets) RCT Significant heterogeneity, random effect model used Four of six studies suggest benefit All studies from the developing countries The duration of the studies ranged from 2-12 months 404 986 RR: 0.43 [0.35, 0.52]
Hemoglobin: Moderate outcome specific quality of evidence
Fourteen studies (Fifteen data sets) RCT Significant heterogeneity, random effect model used Nine studies suggest benefit All studies from the developing countries Studies ranged in duration from 2-12 months. 4571 3783 SMD: 0.98 [0.55, 0.40]
Serum Zinc: Moderate outcome specific quality of evidence
Three RCT Significant heterogeneity so a random effect model used One study suggested benefit All studies from developing countries One study was conducted in school 761 788 SMD: -0.22 [-0.52, 0.09]
Serum Retinol: Moderate outcome specific quality of evidence
Two RCT Significant heterogeneity so a random effect model used One study suggest benefit Both studies from India Study duration ranged from 6-8 months. 464 504 SMD: 1.66 [-1.60, 4.92]
Serum Ferritin: Moderate outcome specific quality of evidence
Four RCT Significant heterogeneity, random effect model used Three studies suggest benefit All studies from developing countries Studies ranged in duration from 6 months to 12 months 850 884 SMD: 1.78 [-0.31, 3.88]
Zinc Deficiency: Moderate outcome specific quality of evidence
Two RCT No significant heterogeneity, fixed effect model used None of the study suggests benefit All studies from the developing countries The study duration ranged from 6-8 months. 258 272 RR: 1.02 [0.87, 1.19]
Retinol Deficiency: Moderate outcome specific quality of evidence
Three RCT No significant heterogeneity, fixed effect model used None of the study suggests benefit All studies from the developing countries The study duration ranged from 6-12 months. 111 145 RR: 0.79 [0.64, 0.98]