Table 2 Quality Assessment by Hematologic Outcome
From: Effectiveness of Micronutrient Powders (MNP) in women and children
| Â | Quality Assessment | Summary of Findings | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Directness | No of events | Â | |||||
No of studies | Design | Limitations | Consistency | Generalizability to population of interest | Generalizability to intervention of interest | Intervention | Control | RR / SMD (95% CI) |
Anemia: Moderate outcome specific quality of evidence | ||||||||
Eleven | RCT | Significant heterogeneity, random effect model used | Six of ten studies suggest benefit | All studies from the developing countries | The duration of the studies ranged from 2-12 months and the age of the children from 6 months to 10 years. | 1081 | 1443 | RR: 0.66 [0.57, 0.77] |
Iron deficiency Anemia: Moderate outcome specific quality of evidence | ||||||||
Seven studies (six data sets) | RCT | Significant heterogeneity, random effect model used | Four of six studies suggest benefit | All studies from the developing countries | The duration of the studies ranged from 2-12 months | 404 | 986 | RR: 0.43 [0.35, 0.52] |
Hemoglobin: Moderate outcome specific quality of evidence | ||||||||
Fourteen studies (Fifteen data sets) | RCT | Significant heterogeneity, random effect model used | Nine studies suggest benefit | All studies from the developing countries | Studies ranged in duration from 2-12 months. | 4571 | 3783 | SMD: 0.98 [0.55, 0.40] |
Serum Zinc: Moderate outcome specific quality of evidence | ||||||||
Three | RCT | Significant heterogeneity so a random effect model used | One study suggested benefit | All studies from developing countries | One study was conducted in school | 761 | 788 | SMD: -0.22 [-0.52, 0.09] |
Serum Retinol: Moderate outcome specific quality of evidence | ||||||||
Two | RCT | Significant heterogeneity so a random effect model used | One study suggest benefit | Both studies from India | Study duration ranged from 6-8 months. | 464 | 504 | SMD: 1.66 [-1.60, 4.92] |
Serum Ferritin: Moderate outcome specific quality of evidence | ||||||||
Four | RCT | Significant heterogeneity, random effect model used | Three studies suggest benefit | All studies from developing countries | Studies ranged in duration from 6 months to 12 months | 850 | 884 | SMD: 1.78 [-0.31, 3.88] |
Zinc Deficiency: Moderate outcome specific quality of evidence | ||||||||
Two | RCT | No significant heterogeneity, fixed effect model used | None of the study suggests benefit | All studies from the developing countries | The study duration ranged from 6-8 months. | 258 | 272 | RR: 1.02 [0.87, 1.19] |
Retinol Deficiency: Moderate outcome specific quality of evidence | ||||||||
Three | RCT | No significant heterogeneity, fixed effect model used | None of the study suggests benefit | All studies from the developing countries | The study duration ranged from 6-12 months. | 111 | 145 | RR: 0.79 [0.64, 0.98] |