Skip to main content

Table 3 Quality assessment of studies on lactose-free versus lactose-containing liquid feeds

From: Dietary management of childhood diarrhea in low- and middle-income countries: a systematic review

   QUALITY ASSESSMENT SUMMARY OF FINDINGS
Number of studies Diarrhea mode Design Limitations Consistency Generalizability to population of interest Overall quality of evidence Number of events in intervention group Number of events in control group Effect size (95% CI)
OUTCOME: DURATION OF DIARRHEA Standardized Mean Difference
5 Acute RCT Study quality ranges from moderate to high Heterogeneous (I2= 60%) Infants and young children (≤24m) with acute diarrhea, without severe malnutrition, in LMICs Moderate - - -0.36 [-0.62, -0.10]
0 Persistent RCT No studies - - - - - -
OUTCOME: STOOL OUTPUT Standardized Mean Difference
3 Acute RCT Study quality ranges from moderate to high Heterogeneous (I2= 76%) Infants and young children (≤24m) with acute diarrhea, without severe malnutrition, in LMICs Moderate - - -0.26 [-0.80, 0.28]
0 Persistent RCT No studies - - - - - -
OUTCOME: WEIGHT GAIN Standardized Mean Difference
3 Acute RCT Study quality ranges from moderate to high Heterogeneous (I2= 41%) Infants and young children (≤24m) with acute diarrhea, not severely malnourished, in LMICs Moderate - - 0.05 [-0.22, 0.33]
1 Persistent RCT Single study of low quality - Infants and young children (≤22m) with persistent diarrhea, not dehydrated or severely malnourished, in LMICs Very low - - 0.90 (0.07, 1.73)
OUTCOME: TREATMENT FAILURE Risk Ratio
7 Acute RCT Study quality ranges from low to high Consistent (I2= 0%) Infants and young children (≤24m) with acute diarrhea, not severely malnourished, in LMICs Moderate 50 57 0.53 [0.40, 0.70]
2 Persistent RCT Only two studies, of low and high quality Consistent (I2= 0%) Infants and young children (≤36m) with persistent diarrhea, not severely malnourished, in LMICs Low 4 11 0.17 [0.06, 0.48]