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Table 2 Quality assessment of studies on reduced lactose versus regular lactose liquid feeds

From: Dietary management of childhood diarrhea in low- and middle-income countries: a systematic review

   QUALITY ASSESSMENT SUMMARY OF FINDINGS
Number of studies Diarrhea mode Design Limitations Consistency Generalizability to population of interest Overall quality of evidence Number of events in intervention group Number of events in control group Effect size (95% CI)
OUTCOME: DURATION OF DIARRHEA Standardized Mean Difference
4 Acute RCT Study quality ranges from low to high Heterogeneous (I2= 82%) Infants and young children (≤36m) with acute diarrhea, not severely malnourished, in LMICs Low - - -0.49 [-1.04, 0.07]
0 Persistent RCT No studies - - - - - -
OUTCOME: STOOL OUTPUT Standardized Mean Difference
3 Acute RCT Study quality ranges from moderate to high Consistent (I2= 41%) Infants with acute diarrhea, not severely malnourished, in LMICs Moderate - - -0.18 [-0.56, 0.19]
1 Persistent RCT Single study of moderate quality - Non-malnourished, non-breastfed infants with persistent diarrhea in LMICs Low - - -0.25 (-0.73, 0.24)
OUTCOME: WEIGHT GAIN Standardized Mean Difference
2 Acute RCT Only two studies, of moderate to high quality Consistent (I2= 0%) Infants with acute diarrhea, not severely malnourished, in LMICs Moderate - - -0.02 [-0.29, 0.25]
1 Persistent RCT Single study of moderate quality - Non-malnourished, non-breastfed infants with persistent diarrhea in LMICs Low - - 0.39 (-0.09, 0.87)
OUTCOME: TREATMENT FAILURE Risk Ratio
6 Acute RCT Study quality ranges from moderate to high; two studies report zero event counts in both groups Consistent (I2= 0%) Infants and young children (≤48m) with acute diarrhea, not severely malnourished, in LMICs Moderate 30 31 1.08 [0.71, 1.64]
1 Persistent RCT Single study of moderate quality - Non-malnourished, non-breastfed infants with persistent diarrhea in LMICs Low 4 15 0.27 [0.10, 0.74]