Antibiotics for the treatment of Cholera, Shigella and Cryptosporidiumin children

BMC Public Health

Table 3 Quality assessment of trials of antibiotics for the treatment of cryptosporidium

Quality Assessment						Summary of Findings
				Directness		No of events
No of studies	Design	Limitations	Consistency	Generalizability to population of interest	Generalizability to intervention of interest	Intervention	Control	Relative Risk (95%CI)
Mortality – All Cause (Antibiotics vs. Placebo): Low Outcome Quality
02[30, 32]	RCT	One study used nitazoxanide while one used spiramycin	All studies suggested benefit	All studies were conducted in developing country	Hospital based	1	6	0.24 [0.04, 1.45] ^a
*Clinical Failure (Antibiotics vs. Placebo): Moderate Outcome Quality*
02[30, 31]	RCT		Both used nitazoxanide and suggested benefit	All studies were conducted in developing country	Hospital based	14	32	0.48 (0.30, 0.75) ^a
*Parasitological Failure (Antibiotics vs. Placebo): Moderate Outcome Quality*
03[30–32]	RCT	Two studies used nitazoxanide While one used spiramycin	All studies suggest benefit	All studies were conducted in developing country	Hospital based	31	51	0.62 [0.46, 0.83] ^a

ISSN: 1471-2458