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Table 3 Quality assessment of trials of antibiotics for the treatment of cryptosporidium

From: Antibiotics for the treatment of Cholera, Shigella and Cryptosporidiumin children

Quality Assessment Summary of Findings
  Directness No of events  
No of studies Design Limitations Consistency Generalizability to population of interest Generalizability to intervention of interest Intervention Control Relative Risk (95%CI)
Mortality – All Cause (Antibiotics vs. Placebo): Low Outcome Quality
02[30, 32] RCT One study used nitazoxanide while one used spiramycin All studies suggested benefit All studies were conducted in developing country Hospital based 1 6 0.24 [0.04, 1.45] a
Clinical Failure (Antibiotics vs. Placebo): Moderate Outcome Quality
02[30, 31] RCT   Both used nitazoxanide and suggested benefit All studies were conducted in developing country Hospital based 14 32 0.48 (0.30, 0.75) a
Parasitological Failure (Antibiotics vs. Placebo): Moderate Outcome Quality
03[3032] RCT Two studies used nitazoxanide While one used spiramycin All studies suggest benefit All studies were conducted in developing country Hospital based 31 51 0.62 [0.46, 0.83] a
  1. a= Fixed Effect Model
  2. b= Random Effect Model