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Table 1 Study visit schedule outlining procedures and assessments performed at each visit

From: The Study of the Prevention of Anal Cancer (SPANC): design and methods of a three-year prospective cohort study

  Baseline Follow-up (+/− 3 months)  
Visit number 1 2 3 4 5 6
Study months 0 6 12 24 36 38
Interview process       
 Informed consent X      
 Baseline interview X      
 Follow up Interview   X X X X  
 Psychological interview X X X X X  
Clinical process       
 Venepuncture X   X X X  
 Digital ano-rectal exam X X X X X  
 Anal swab X X X X X  
 Urine sample & throat swab1 X   
 High resolution anoscopy & biopsy X X X X X  
 Discussion of all study results and anal cancer risk       x
Laboratory process       
 HIV testing2 X   
 Syphilis testing 1 X   
 Anal cytology X X X X X  
 Histology3 X X X X X  
 Gonorrhoea and chlamydia testing1 X   
  1. 1Syphilis, anal, pharyngeal and urethral gonorrhoea, and anal and urethral chlamydia testing: participants who reported sexual activity since the last annual visit undergo anal STI testing at the follow up visit (as indicated by ¶). 2HIV testing: only HIV-negative participants. Follow up testing is performed in HIV-negative men who report sexual activity since the last HIV test (as indicated by ¶). 3Biopsy and histology: participants with lesions seen at high resolution anoscopy undergo biopsy for further histological assessment.