House calls by community health workers and public health nurses to improve adherence to isoniazid monotherapy for latent tuberculosis infection: a retrospective study

Table 4 Reasons for not completing INH treatment for latent tuberculosis infection

Reason	Home follow-up^a		Clinic follow-up^b		P-value^c
Reason	N=986	(%)	N=2932	(%)	P-value^c
Adverse reaction	24	(2.4)	105	(3.6)	0.24
Abnormal liver enzymes^d	3	(0.3)	40	(1.4)	0.02
INH –related hepatitis ^e	1	(0.1)	23	(0.8)	0.06 ^f
Rash	7	(0.7)	30	(1.0)	0.58
Other symptoms^g	14	(1.4)	35	(1.2)	0.58
Refused/Lost^h	75	(7.6)	680	(23.2)	<0.001

^aHome-based follow-up with community health workers and public health nurses.
^bClinic-based follow-up.
^cAnalysis by chi-square or Fisher’s exact test, adjusted for multiple comparisons.
^dAny abnormality of liver enzymes associated with treatment discontinuation.
^eSubset of patients with abnormal liver enzymes with isoniazid-related hepatitis, based on chart review.
^fp-value for INH-related hepatitis only.
^gAny other intolerable symptom that necessitated treatment discontinuation such as headache, dizziness, fatigue, among others.
^hRefused to continue treatment or were lost to follow-up.

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