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Table 4 Reasons for not completing INH treatment for latent tuberculosis infection

From: House calls by community health workers and public health nurses to improve adherence to isoniazid monotherapy for latent tuberculosis infection: a retrospective study

Reason Home follow-upa Clinic follow-upb P-valuec
N=986 (%) N=2932 (%)
Adverse reaction 24 (2.4) 105 (3.6) 0.24
Abnormal liver enzymesd 3 (0.3) 40 (1.4) 0.02
INH –related hepatitis e 1 (0.1) 23 (0.8) 0.06 f
Rash 7 (0.7) 30 (1.0) 0.58
Other symptomsg 14 (1.4) 35 (1.2) 0.58
Refused/Losth 75 (7.6) 680 (23.2) <0.001
  1. aHome-based follow-up with community health workers and public health nurses.
  2. bClinic-based follow-up.
  3. cAnalysis by chi-square or Fisher’s exact test, adjusted for multiple comparisons.
  4. dAny abnormality of liver enzymes associated with treatment discontinuation.
  5. eSubset of patients with abnormal liver enzymes with isoniazid-related hepatitis, based on chart review.
  6. fp-value for INH-related hepatitis only.
  7. gAny other intolerable symptom that necessitated treatment discontinuation such as headache, dizziness, fatigue, among others.
  8. hRefused to continue treatment or were lost to follow-up.