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Table 4 Multivariate logistic regression models using data obtained from multiple imputation: women (n = 3302)

From: Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study

   Model 1 early life factors   Model 2 + childhood pathologies and ACEs   Model 3 + adult mediating factors  
   OR (95% CI) p OR (95% CI) p OR (95% CI) p
Mother’s education Left school after min age       
  Left school at or before min age 1.06 (0.80-1.41) 0.681 1.06 (0.79-1.41) 0.697 1.07 (0.79-1.45) 0.659
Father’s social class Non-manual       
  Manual 1.17 (0.88-1.56) 0.286 1.11 (0.83-1.49) 0.473 1.13 (0.84-1.53) 0.419
Overcrowded household <1.5 people per room       
  > = 1.5 people per room 1.47 (1.07-2.04) 0.019 1.39 (1.0-1.92) 0.051 1.33 (0.95-1.85) 0.093
Gestational age (days) 1.00 (0.99-1.01) 0.648 1.00 (0.99-1.01) 0.664 1.00 (0.99-1.01) 0.889
Parity Primiparous       
  One 1.17 (0.88-1.57) 0.283 1.14 (0.85-1.52) 0.391 1.06 (0.78-1.43) 0.715
  Two or more 1.32 (0.95-1.83) 0.095 1.20 (0.86-1.67) 0.279 1.09 (0.77-1.54) 0.642
Birthweight (kg) 0.90 (0.70-1.16) 0.425 0.91 (0.71-1.18) 0.488 0.93 (0.72-1.21) 0.585
Fœtal distress No       
  Yes 1.24 (0.81-1.89) 0.316 1.25 (0.82-1.90) 0.306 1.23 (0.81-1.89) 0.334
Problems during pregnancy No       
  Yes 1.16 (0.91-1.49) 0.240 1.13 (0.88-1.45) 0.332 1.14 (0.88-1.47) 0.324
Smoking during pregnancy No       
  Sometimes 1.08 (0.65-1.79) 0.771 0.94 (0.56-1.57) 0.801 0.91 (0.54-1.54) 0.739
  Moderately 1.07 (0.78-1.49) 0.664 1.06 (0.76-1.46) 0.742 1.00 (0.72-1.39) 0.997
  Heavily 1.30 (0.93-1.82) 0.126 1.22 (0.87-1.72) 0.251 1.17 (0.82-1.66) 0.384
Mother’s age at birth (years) 0.98 (0.95-1.00) 0.040 0.98 (0.96-1.00) 0.086 0.98 (0.96-1.01) 0.176
Breastfed Yes, for more than 1 month       
  Yes, for up to one month 1.10 (0.83-1.46) 0.517 1.09 (0.81-1.45) 0.567 1.08 (0.80-1.45) 0.627
  No 1.14 (0.87-1.51) 0.340 1.09 (0.82-1.44) 0.550 1.08 (0.81-1.43) 0.601
Childhood pathologies No       
  Yes    1.31 (0.99-1.73) 0.061 1.24 (0.93-1.65) 0.149
ACE No adversities       
  One adversity    1.40 (1.06-1.83) 0.016 1.30 (0.98-1.72) 0.066
  Two or more adversities    2.46 (1.66-3.65) <0.001 2.14 (1.42-3.21) <0.001
Age at 1st pregnancy <=33y       
  >34y      2.24 (1.63-3.08) <0.001
  No pregnancies, or no information      0.94 (0.65-1.34) 0.716
Education level at 23 y A levels or higher       
  O levels      0.95 (0.67-1.34) 0.756
  No qualifications      1.30 (0.87-1.93) 0.198
Social class 23 y Non-manual active       
  manual active      0.93 (0.64-1.37) 0.726
  Inactive      1.04 (0.77-1.41) 0.796
Smoking 23 y Never       
  Past      1.27 (0.9-1.78) 0.174
  Current      1.72 (1.25-2.36) 0.001
Alcohol 23 y Normal       
  Abstainance      1.00 (0.66-1.52) 0.983
  Heavy      1.42 (0.99-2.04) 0.055
Psychological malaise 23 y No       
  Yes      1.35 (0.94-1.93) 0.099
BMI groups Normal       
  Underweight      1.26 (0.81-1.95) 0.299
  Overweight      0.93 (0.63-1.37) 0.706
  Obese      0.47 (0.17-1.24) 0.126