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Table 4 Multivariate logistic regression models using data obtained from multiple imputation: women (n = 3302)

From: Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study

  

Model 1 early life factors

 

Model 2 + childhood pathologies and ACEs

 

Model 3 + adult mediating factors

 
  

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

Mother’s education

Left school after min age

      
 

Left school at or before min age

1.06 (0.80-1.41)

0.681

1.06 (0.79-1.41)

0.697

1.07 (0.79-1.45)

0.659

Father’s social class

Non-manual

      
 

Manual

1.17 (0.88-1.56)

0.286

1.11 (0.83-1.49)

0.473

1.13 (0.84-1.53)

0.419

Overcrowded household

<1.5 people per room

      
 

> = 1.5 people per room

1.47 (1.07-2.04)

0.019

1.39 (1.0-1.92)

0.051

1.33 (0.95-1.85)

0.093

Gestational age

(days)

1.00 (0.99-1.01)

0.648

1.00 (0.99-1.01)

0.664

1.00 (0.99-1.01)

0.889

Parity

Primiparous

      
 

One

1.17 (0.88-1.57)

0.283

1.14 (0.85-1.52)

0.391

1.06 (0.78-1.43)

0.715

 

Two or more

1.32 (0.95-1.83)

0.095

1.20 (0.86-1.67)

0.279

1.09 (0.77-1.54)

0.642

Birthweight

(kg)

0.90 (0.70-1.16)

0.425

0.91 (0.71-1.18)

0.488

0.93 (0.72-1.21)

0.585

FÅ“tal distress

No

      
 

Yes

1.24 (0.81-1.89)

0.316

1.25 (0.82-1.90)

0.306

1.23 (0.81-1.89)

0.334

Problems during pregnancy

No

      
 

Yes

1.16 (0.91-1.49)

0.240

1.13 (0.88-1.45)

0.332

1.14 (0.88-1.47)

0.324

Smoking during pregnancy

No

      
 

Sometimes

1.08 (0.65-1.79)

0.771

0.94 (0.56-1.57)

0.801

0.91 (0.54-1.54)

0.739

 

Moderately

1.07 (0.78-1.49)

0.664

1.06 (0.76-1.46)

0.742

1.00 (0.72-1.39)

0.997

 

Heavily

1.30 (0.93-1.82)

0.126

1.22 (0.87-1.72)

0.251

1.17 (0.82-1.66)

0.384

Mother’s age at birth

(years)

0.98 (0.95-1.00)

0.040

0.98 (0.96-1.00)

0.086

0.98 (0.96-1.01)

0.176

Breastfed

Yes, for more than 1 month

      
 

Yes, for up to one month

1.10 (0.83-1.46)

0.517

1.09 (0.81-1.45)

0.567

1.08 (0.80-1.45)

0.627

 

No

1.14 (0.87-1.51)

0.340

1.09 (0.82-1.44)

0.550

1.08 (0.81-1.43)

0.601

Childhood pathologies

No

      
 

Yes

  

1.31 (0.99-1.73)

0.061

1.24 (0.93-1.65)

0.149

ACE

No adversities

      
 

One adversity

  

1.40 (1.06-1.83)

0.016

1.30 (0.98-1.72)

0.066

 

Two or more adversities

  

2.46 (1.66-3.65)

<0.001

2.14 (1.42-3.21)

<0.001

Age at 1st pregnancy

<=33y

      
 

>34y

    

2.24 (1.63-3.08)

<0.001

 

No pregnancies, or no information

    

0.94 (0.65-1.34)

0.716

Education level at 23 y

A levels or higher

      
 

O levels

    

0.95 (0.67-1.34)

0.756

 

No qualifications

    

1.30 (0.87-1.93)

0.198

Social class 23 y

Non-manual active

      
 

manual active

    

0.93 (0.64-1.37)

0.726

 

Inactive

    

1.04 (0.77-1.41)

0.796

Smoking 23 y

Never

      
 

Past

    

1.27 (0.9-1.78)

0.174

 

Current

    

1.72 (1.25-2.36)

0.001

Alcohol 23 y

Normal

      
 

Abstainance

    

1.00 (0.66-1.52)

0.983

 

Heavy

    

1.42 (0.99-2.04)

0.055

Psychological malaise 23 y

No

      
 

Yes

    

1.35 (0.94-1.93)

0.099

BMI groups

Normal

      
 

Underweight

    

1.26 (0.81-1.95)

0.299

 

Overweight

    

0.93 (0.63-1.37)

0.706

 

Obese

    

0.47 (0.17-1.24)

0.126