Table 3 Multivariate logistic regression models using data obtained from multiple imputation: men (n = 2836)
From: Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study
Model 1 early life factors | Model 2 + childhood pathologies and ACEs | Model 3 + adult mediating factors | |||||
|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | ||
Mother's education | Left school after min age | ||||||
Left school at or before min age | 1.26 (0.73-2.17) | 0.412 | 1.25 (0.72-2.16) | 0.427 | 1.18 (0.67-2.09) | 0.563 | |
Father’s social class | Non-manual | ||||||
Manual | 1.16 (0.68-1.96) | 0.587 | 1.14 (0.67-1.94) | 0.620 | 1.07 (0.62-1.86) | 0.810 | |
Overcrowded household | <1.5 people per room | ||||||
> = 1.5 people per room | 1.43 (0.76-2.68) | 0.265 | 1.40 (0.75-2.64) | 0.295 | 1.36 (0.72-2.59) | 0.344 | |
Gestational age | (days) | 1.01 (0.99-1.03) | 0.444 | 1.01 (0.99-1.03) | 0.445 | 1.01 (0.99-1.03) | 0.444 |
Parity | Primiparous | ||||||
One | 0.73 (0.42-1.26) | 0.263 | 0.72 (0.42-1.25) | 0.245 | 0.71 (0.41-1.23) | 0.215 | |
Two or more | 0.95 (0.52-1.73) | 0.855 | 0.90 (0.48-1.66) | 0.726 | 0.85 (0.45-1.60) | 0.613 | |
Birthweight | (kg) | 0.77 (0.49-1.21) | 0.259 | 0.78 (0.49-1.23) | 0.279 | 0.75 (0.47-1.20) | 0.231 |
Fœtal distress | No | ||||||
Yes | 1.38 (0.72-2.65) | 0.336 | 1.37 (0.71-2.63) | 0.348 | 1.35 (0.70-2.6) | 0.376 | |
Problems during pregnancy | No | ||||||
Yes | 0.69 (0.41-1.18) | 0.175 | 0.69 (0.41-1.18) | 0.180 | 0.71 (0.42-1.21) | 0.210 | |
Smoking during pregnancy | No | ||||||
Sometimes | 1.62 (0.75-3.49) | 0.222 | 1.59 (0.74-3.44) | 0.238 | 1.52 (0.70-3.33) | 0.294 | |
Moderately | 1.38 (0.8-2.37) | 0.250 | 1.36 (0.79-2.35) | 0.270 | 1.36 (0.78-2.36) | 0.281 | |
Heavily | 0.54 (0.21-1.37) | 0.194 | 0.52 (0.2-1.34) | 0.176 | 0.50 (0.20-1.28) | 0.149 | |
Mother’s age at birth | (years) | 0.99 (0.95-1.04) | 0.731 | 0.99 (0.95-1.04) | 0.809 | 1.00 (0.95-1.04) | 0.887 |
Breastfed | Yes, for more than 1 month | ||||||
Yes, for up to one month | 1.03 (0.58-1.81) | 0.924 | 1.04 (0.59-1.82) | 0.905 | 1.04 (0.59-1.84) | 0.898 | |
No | 1.00 (0.59-1.68) | 0.991 | 0.99 (0.59-1.68) | 0.982 | 0.96 (0.56-1.64) | 0.885 | |
Childhood pathologies | No | ||||||
Yes | 0.87 (0.51-1.49) | 0.623 | 0.83 (0.48-1.43) | 0.500 | |||
ACE | No adversities | ||||||
One adversity | 1.11 (0.66-1.87) | 0.687 | 1.03 (0.61-1.76) | 0.904 | |||
Two or more adversities | 1.50 (0.68-3.29) | 0.314 | 1.39 (0.62-3.11) | 0.419 | |||
Education level at 23 y | A levels or higher | ||||||
O levels | 1.00 (0.51-1.96) | 0.995 | |||||
No qualifications | 1.24 (0.56-2.73) | 0.599 | |||||
Social class 23 y | Non-manual active | ||||||
manual active | 0.92 (0.5-1.69) | 0.788 | |||||
Inactive | 1.06 (0.50-2.24) | 0.885 | |||||
Smoking 23 y | Never | ||||||
Past | 1.02 (0.55-1.87) | 0.962 | |||||
Current | 1.21 (0.68-2.18) | 0.516 | |||||
Alcohol 23 y | Normal | ||||||
Abstainance | 1.33 (0.49-3.59) | 0.573 | |||||
Heavy | 1.10 (0.62-1.94) | 0.743 | |||||
Psychological malaise 23 y | No | ||||||
Yes | 0.95 (0.23-3.92) | 0.938 | |||||
BMI groups | Normal | ||||||
Underweight | 1.40 (0.33-5.89) | 0.647 | |||||
Overweight | 1.58 (0.90-2.78) | 0.113 | |||||
Obese | 2.72 (1.17-6.32) | 0.020 |