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Table 3 Multivariate logistic regression models using data obtained from multiple imputation: men (n = 2836)

From: Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study

   Model 1 early life factors   Model 2 + childhood pathologies and ACEs   Model 3 + adult mediating factors  
   OR (95% CI) p OR (95% CI) p OR (95% CI) p
Mother's education Left school after min age       
  Left school at or before min age 1.26 (0.73-2.17) 0.412 1.25 (0.72-2.16) 0.427 1.18 (0.67-2.09) 0.563
Father’s social class Non-manual       
  Manual 1.16 (0.68-1.96) 0.587 1.14 (0.67-1.94) 0.620 1.07 (0.62-1.86) 0.810
Overcrowded household <1.5 people per room       
  > = 1.5 people per room 1.43 (0.76-2.68) 0.265 1.40 (0.75-2.64) 0.295 1.36 (0.72-2.59) 0.344
Gestational age (days) 1.01 (0.99-1.03) 0.444 1.01 (0.99-1.03) 0.445 1.01 (0.99-1.03) 0.444
Parity Primiparous       
  One 0.73 (0.42-1.26) 0.263 0.72 (0.42-1.25) 0.245 0.71 (0.41-1.23) 0.215
  Two or more 0.95 (0.52-1.73) 0.855 0.90 (0.48-1.66) 0.726 0.85 (0.45-1.60) 0.613
Birthweight (kg) 0.77 (0.49-1.21) 0.259 0.78 (0.49-1.23) 0.279 0.75 (0.47-1.20) 0.231
Fœtal distress No       
  Yes 1.38 (0.72-2.65) 0.336 1.37 (0.71-2.63) 0.348 1.35 (0.70-2.6) 0.376
Problems during pregnancy No       
  Yes 0.69 (0.41-1.18) 0.175 0.69 (0.41-1.18) 0.180 0.71 (0.42-1.21) 0.210
Smoking during pregnancy No       
  Sometimes 1.62 (0.75-3.49) 0.222 1.59 (0.74-3.44) 0.238 1.52 (0.70-3.33) 0.294
  Moderately 1.38 (0.8-2.37) 0.250 1.36 (0.79-2.35) 0.270 1.36 (0.78-2.36) 0.281
  Heavily 0.54 (0.21-1.37) 0.194 0.52 (0.2-1.34) 0.176 0.50 (0.20-1.28) 0.149
Mother’s age at birth (years) 0.99 (0.95-1.04) 0.731 0.99 (0.95-1.04) 0.809 1.00 (0.95-1.04) 0.887
Breastfed Yes, for more than 1 month       
  Yes, for up to one month 1.03 (0.58-1.81) 0.924 1.04 (0.59-1.82) 0.905 1.04 (0.59-1.84) 0.898
  No 1.00 (0.59-1.68) 0.991 0.99 (0.59-1.68) 0.982 0.96 (0.56-1.64) 0.885
Childhood pathologies No       
  Yes    0.87 (0.51-1.49) 0.623 0.83 (0.48-1.43) 0.500
ACE No adversities       
  One adversity    1.11 (0.66-1.87) 0.687 1.03 (0.61-1.76) 0.904
  Two or more adversities    1.50 (0.68-3.29) 0.314 1.39 (0.62-3.11) 0.419
Education level at 23 y A levels or higher       
  O levels      1.00 (0.51-1.96) 0.995
  No qualifications      1.24 (0.56-2.73) 0.599
Social class 23 y Non-manual active       
  manual active      0.92 (0.5-1.69) 0.788
  Inactive      1.06 (0.50-2.24) 0.885
Smoking 23 y Never       
  Past      1.02 (0.55-1.87) 0.962
  Current      1.21 (0.68-2.18) 0.516
Alcohol 23 y Normal       
  Abstainance      1.33 (0.49-3.59) 0.573
  Heavy      1.10 (0.62-1.94) 0.743
Psychological malaise 23 y No       
  Yes      0.95 (0.23-3.92) 0.938
BMI groups Normal       
  Underweight      1.40 (0.33-5.89) 0.647
  Overweight      1.58 (0.90-2.78) 0.113
  Obese      2.72 (1.17-6.32) 0.020