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Table 9 Urinary biomarkers

From: A single-blinded, single-centre, controlled study in healthy adult smokers to identify the effects of a reduced toxicant prototype cigarette on biomarkers of exposure and of biological effect versus commercial cigarettes

Biomarker Number and volume of aliquots
4-Aminobiphenyl, 3-Aminobiphenyl, 2 aliquots of 12 mL each
o-Toluidine, 2-Aminonaphthalene
OH-PAHs suite 2 aliquots of 12 mL each
Nicotine + 5 2 aliquots of 6 mL each
3-HPMA, HMPMA, CEMA 2 aliquots of 3 mL each
MHBMA 2 aliquots of 3 mL each
Total NNAL, NNN, NAB and NAT 2 aliquots of 10 mL each
F2-isoprostane (8-iso-PGF2 Type III) 2 aliquots of 6 mL each
F2-isoprostane (8-iso-PGF2 Type VI) 2 aliquots of 6 mL each
11-dehydrothromboxane B2 2 aliquots of 3 mL each
Urine mutagenicity 1 aliquots of 300 mL each
8-OHdG 2 aliquots of 1.5 mL each
Cis-thymidine glycol 2 aliquots of 1.5 mL each
  1. OH-PAH, phenolic polycyclic aromatic hydrocarbons.3-HPMA, 3-Hydroxypropylmercapturic acid.
  2. HMPMA, 3-hydroxy-1-methylpropylmercapturic acid. CEMA, 2-cyanoethylmercapturic acid.
  3. MHBMA, monohydroxy-3-butenylmercapturic acid. NNAL, 4-(methylnitrosamino-1-(3-pyridyl)-1-butanol.
  4. NNN, N-nitrosonornicotine. NAB, N-nitrosoanabasine. NAT, N-nitrosoanatabine.
  5. 8-OhdG, 8-Oxo-2′-deoxyguanosine.