Day and suggested times | Sampling | Procedure |
---|---|---|
181 | ||
1700 h (check in) | Blood, urine | Measure BP, PR, RR and temperature; abbreviated physical examination and medical history; illicit drug, alcohol and cotinine testing; pregnancy testing; collection of diary and cigarette butts; dinner |
1900 h | None | Start first 24 h urine collection, monitoring of cigarette consumption and collection of filters |
2100 h | None | Snack |
182 | ||
0700 h | Blood | Measure BP, PR, RR and temperature; measure creatinine in serum; biomarkers and gene expression |
0800 h | None | Breakfast |
To be scheduled | None | Assess smoking behavioura |
1000 h | None | Administer sensory, quality-of-life and diet and lifestyle questionnaires† |
1200 h | None | Lunch |
1500 h | None | Measure exhaled CO |
1700 h | Saliva | Cotinine testing; dinner |
1900 h | None | End first and start second 24 h urine collection, monitoring of cigarette consumption and collection of filters |
2100 h | None | Snack |
183 | ||
Anytime (check out) | None | Measure BP, PR, RR and temperature; physical examination; electrocardiography |
0700 h | Blood | Measure creatinine in serum; biomarkers |
0800 h | None | Breakfast |
To be scheduled | None | Assess smoking behavioura |
1100 h | None | Pulmonary-function test |
1200 h | None | Lunch |
1500 h | None | Measure exhaled CO |
1700 h | Saliva | Cotinine testing; dinner |
1900 h | None | End second 24 h urine collection, monitoring of cigarette consumption and collection of filters; dispense adequate commercial products of normal ISO tar yield for 7 post-study days |