Table 4 Schedule for first in-clinic evaluation of smokers
Day and suggested times | Sampling | Procedure |
|---|---|---|
12 | ||
1700 h (check in) | Blood, urine | Measure BP, PR, RR and temperature; abbreviated physical examination and medical history; illicit drug, alcohol and cotinine testing; pregnancy testing; collection of diary and cigarette butts; dinner |
1900 h | None | Start first 24 h urine collection, monitoring of cigarette consumption and collection of filters |
2100 h | None | Snack |
13 | ||
0700 h | Blood | Measure BP, PR, RR and temperature; blood collection for creatinine in serum, biomarkers and gene expression |
0800 h | None | Breakfast |
To be scheduled | None | Assess smoking behavioura |
1000 h | None | Administer sensory, quality-of-life and diet and lifestyle questionnairesb |
1200 h | None | Lunch |
1500 h | None | Measure exhaled CO |
1700 h | Saliva | Saliva cotinine testing; dinner |
1900 h | None | End first and start second 24 h urine collection, monitoring of cigarette consumption and collection of filters |
2100 h | None | Snack |
14 | ||
0700 h | Blood | Measure BP, PR, RR and temperature; blood collection for creatinine in serum, biomarkers and gene expression |
0800 h | None | Breakfast |
To be scheduled | None | Assess smoking behavioura |
1100 h | None | Pulmonary-function test |
1200 h | None | Lunch |
1500 h | None | Measure exhaled CO |
1700 h | Saliva | Saliva cotinine testing; dinner |
1900 h | None | End second 24 h urine collection, monitoring of cigarette consumption and collection of filters; switch to next assigned product |
2100 h | None | Snack |
15 | ||
0700 h | None | Measure BP, PR, RR and temperature |
0800 h | None | Breakfast |
1000 h | None | Administer sensory questionnaire |
1200 h | None | Lunch |
1700 h | None | Dinner |
1900 h | None | End filter collection; dispense interventional products and cigarette butt collection tins for use at home, remind participants of instructions for diet and completion of diaries |