Table 2 Strong inducers or inhibitors of CYP (cytochrome P450) enzymes[19]
INHIBITORS | |||
|---|---|---|---|
1A2 | 2B6 | 2C8 | 2C19 |
Cimetidine | Thiotepa | Gemfibrozil | Fluoxetine |
Fluoroquinolones | Ticlopidine | Montelukast | Fluvoxamine |
Fluvoxamine | Ketoconazole | ||
Ticlopidine | Lansoprazole | ||
Omeprazole | |||
Ticlopidine | |||
INHIBITORS | |||
2C9 | 2D6 | 2E1 | 3A4,5,7 |
Amiodarone | Amiodarone | Disulfiram | HIV antivirals: |
Fluconazole | Bupropion | Indinavir | |
Isoniazid | Chlorpheniramine | Nelfinavir | |
Cimetidine | Ritonavir | ||
Clomipramine | Amiodarone | ||
Duloxetine | NOT azithromycin | ||
Fluoxetine | Cimetidine | ||
Haloperidol | Clarithromycin | ||
Methadone | Diltiazem | ||
Mibefradil | Erythromycin | ||
Paroxetine | Fluvoxamine | ||
Quinidine | Itraconazole | ||
Ritonavir | Ketoconazole | ||
Doxepin | Mibefradil | ||
Nefazodone | |||
Troleandomycin | |||
Verapamil | |||
INDUCERS | |||
1A2 | 2B6 | 2C8 | 2C19 |
N/A | Phenobarbital | N/A | N/A |
Phenytoin | |||
Rifampin | |||
2C9 | 2D6 | 2E1 | 3A4,5,7 |
Rifampin | N/A | Isoniazid | Carbamazepine |
Secobarbital | Phenobarbital | ||
Phenytoin | |||
Pioglitazone | |||
Rifabutin | |||
Rifampin | |||
St John’s wort | |||
Troglitazone | |||