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Table 2 Strong inducers or inhibitors of CYP (cytochrome P450) enzymes[19]

From: A single-blinded, single-centre, controlled study in healthy adult smokers to identify the effects of a reduced toxicant prototype cigarette on biomarkers of exposure and of biological effect versus commercial cigarettes

INHIBITORS
1A2 2B6 2C8 2C19
Cimetidine Thiotepa Gemfibrozil Fluoxetine
Fluoroquinolones Ticlopidine Montelukast Fluvoxamine
Fluvoxamine    Ketoconazole
Ticlopidine    Lansoprazole
    Omeprazole
    Ticlopidine
INHIBITORS
2C9 2D6 2E1 3A4,5,7
Amiodarone Amiodarone Disulfiram HIV antivirals:
Fluconazole Bupropion   Indinavir
Isoniazid Chlorpheniramine   Nelfinavir
  Cimetidine   Ritonavir
  Clomipramine   Amiodarone
  Duloxetine   NOT azithromycin
  Fluoxetine   Cimetidine
  Haloperidol   Clarithromycin
  Methadone   Diltiazem
  Mibefradil   Erythromycin
  Paroxetine   Fluvoxamine
  Quinidine   Itraconazole
  Ritonavir   Ketoconazole
  Doxepin   Mibefradil
    Nefazodone
    Troleandomycin
    Verapamil
INDUCERS
1A2 2B6 2C8 2C19
N/A Phenobarbital N/A N/A
  Phenytoin   
  Rifampin   
2C9 2D6 2E1 3A4,5,7
Rifampin N/A Isoniazid Carbamazepine
Secobarbital    Phenobarbital
    Phenytoin
    Pioglitazone
    Rifabutin
    Rifampin
    St John’s wort
    Troglitazone
  1. (Adapted with permission from Version 5.0 (http://medicine.iupui.edu/clinpharm/ddis/table.aspx)).
  2. 1A2, 2B6 etc = CYP enzyme subtypes.