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Table 4 Off-label medicine use by ATC-classes and age groups, KiGGS 2003-2006

From: Off-label medicine use in children and adolescents: results of a population-based study in Germany

ATC-class 0-2 years 3-6 years 7-10 years 11-13 years 14-17 years
n (%) n (%) n (%) n (%) n (%)
A00 Alimentary tract and metabolism 328 (21.3) 255 (49.5) 172 (50.0) 108 (47.8) 130 (43.0)
B00 Blood and blood forming organs 2 (13.3) 1 (14.3) 2 (50.0) 10 (52.6) 9 (32.1)
C00 Cardiovascular system 3 (100) 2 (40.0) 9 (64.3) 9 (90.0) 16 (61.5)
D00 Dermatologicals 102 (26.6) 106 (30.1) 110 (31.0) 75 (37.1) 92 (32.1)
G00 Genito urinary system and sex hormones 4 (66.7) 1 (10.0) 6 (50.0) 2 (25.0) 53 (11.5)
H00 Systemic hormon. preparations excl. sex hormones and insulins 3 (14.3) 11 (19.3) 7 (13.7) 7 (9.5) 14 (15.2)
J00 Antiinfectives for systemic use 29 (32.2) 41 (36.6) 18 (30.5) 15 (31.9) 19 (28.8)
L00 Antineoplastic and immunmodulating agents 7 (70.0) 16 (57.1) 8 (42.1) 6 (42.9) 7 (50.0)
M00 Musculo-skeletal system 13 (25.5) 17 (23.3) 18 (16.8) 21 (18.9) 28 (13.4)
N00 Nervous system 20 (12.7) 21 (20.2) 51 (25.5) 39 (16.5) 44 (11.1)
P00 Antiparasitic products insecticides and repellents 1 (33.3) 1 (20.0) 1 (14.3) 0  
R00 Respiratory system 356 (39.1) 493 (40.4) 288 (35.7) 146 (30.7) 133 (27.7)
S00 Sensory organs 30 (56.6) 30 (42.3) 13 (61.9) 11 (36.7) 8 (32.0)
V00 Various 16 (16.3) 6 (25.0) 7 (16.7) 1 (5.6) 5 (13.9)
Z00 Homoeopathics 41 (23.2) 47 (20.3) 37 (19.2) 22 (20.6) 22 (23.9)
TOTAL n = 12,667 954 (27.1) 1048 (37.3) 747 (33.5) 473 (29.8) 580 (23.0)