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Table 2 Multivariable analysis of factors associated with infants measles log 10 antibody responses at one year of age, following immunisation at 9 months

From: Factors affecting the infant antibody response to measles immunisation in Entebbe-Uganda

 

Univariable analysis

Multivariable analysis1

Explanatory variable

Status

Proportion (%) with protective antibody levels

P-value2

Mean (SD) Log10antibody levels

Difference (95% confidence interval)

P-value

Difference (95% confidence interval)

P-value3

Gravidity

1

147/184 (80)

0.009

2.54 (0.48)

 

0.06

 

0.06

2–4

310/413 (75)

 

2.55 (0.51)

0.01 (−0.08, 0.10)

 

0.01 (−0.08, 0.10)

 

5+

73/114 (64)

 

2.42 (0.57)

−0.12 (−0.24, 0.001)

 

−0.12(−0.24, 0.001)

 

Maternal malaria infection

No

484/646 (75)

0.3

2.54 (0.51)

 

0.09

 

0.05

Yes

37/54 (68)

 

2.41 (0.67)

−0.13 (−0.27, 0.02)

 

−0.14 (−0.29, 0.002)

 

Infant asymptomatic malaria at age one year

No

486/647 (75)

0.07

2.54 (0.51)

 

0.003

 

0.003

Yes

25/40 (62)

 

2.29 (0.59)

−0.25 (−0.42, -0.09)

 

−0.25 (−0.41, -0.08)

 

Infant HIV

Unexposed

482/637 (76)

0.003

2.54 (0.50)

 

0.002

 

0.003

Exposed, uninfected

44/62 (71)

 

2.48 (0.54)

−0.06 (−0.19, 0.07)

 

−0.05 (−0.18, 0.09)

 

Infected

4/12 (33)

 

2.02 (0.85)

−0.52( −0.82, -0.23)

 

−0.50 (−0.80, -0.21)

 

Weight-for length/height (wasting)

No

514/684 (75)

0.06

2.54 (0.50)

 

0.01

 

0.04

 

Yes

16/27 (59)

 

2.28 (0.78)

−0.26 (−0.45, -0.06)

 

−0.21 (−0.41, -0.01)

 
  1. SD Standard deviation; 1in multivariable analyses, maternal asymptomatic malaria was adjusted for gravidity, infant asymptomatic malaria and HIV were adjusted for each other and for gravidity and maternal malaria infection, wasting was adjusted for all other variables in the table 2chi2 test 3likelihood ratio test.