Table 1 Papers analysed by year of publication
From: Challenges to evaluating complex interventions: a content analysis of published papers
2002 | |
Loeb MB. Application of the development stages of a cluster randomized trial to a framework for valuating complex health interventions. BMC Health Serv Res 2002 2:13 | Methodology |
Műhlhauser I, Berger, M. Patient education - evaluation of a complex intervention. Diabetologia 2002 45:1723-1733 | Health promotion |
Nazareth I, Freemantle N, Duggan C, Mason J, Haines, A. Evaluation of a complex intervention for changing professional behaviour: the Evidence Based Out Reach (EBOR) Trial. J Health Serv Res Policy 2002 7:230-238 | Health promotion |
Treweek SP, Glenton C, Oxman AD, Penrose A. Computer-generated patient education materials: do they affect professional practice? A systematic review. 2002 J Am Med Inform Assoc 4:346-358 | Health promotion |
2003 | |
Emery JD. Effect of computerised evidence based guidelines. BMJ 2003 326:394 | Methodology |
Glazener CM, Evans JH, Peto RE. Tricyclic and related drugs for nocturnal enuresis in children. Cochrane Database Syst Rev 2003 3:CD002117 | Clinical |
Lyles JS, Hodges A, Collins C, Lein C, Given CW, Given B, D'Mello D, Osborn GG, Goddeeris J, Gardiner JC, Smith RC. Using nurse practitioners to implement an intervention in primary care for high-utilizing patients with medically unexplained symptoms. Gen Hosp Psychiatry 2003 25:63-73 | Clinical |
Omar R. The evidence for prosthodontic treatment planning for older, partially dentate patients. Med Princ Pract 2003 12 Suppl 1:33-42 | Clinical |
Rollnick S. General practitioner screening for excessive alcohol use. Paper enables open debate about a complex intervention. BMJ 2003 326:336 | Health promotion |
2004 | |
Byng R, Jones R. Mental Health Link: the development and formative evaluation of a complex intervention to improve shared care for patients with long-term mental illness. J Eval Clin Pract 2004 10:27-36 | Methodology |
Conway TL, Woodruff SI, Edwards CC, Hovell MF, Klein J. Intervention to reduce environmental tobacco smoke exposure in Latino children: null effects on hair biomarkers and parent reports. Tob Control 2004 13:90-92 | Health promotion |
Drescher U, Warren F, Norton K. Towards evidence-based practice in medical training: making evaluations more meaningful. Med Educ 2004 12:1288-1294 | Methodology |
Figar S, Waisman G, De Quiros FG, Galarza C, Marchetti M, Loria GR, Camera L, Seinhart D, Camera M. Narrowing the gap in hypertension: effectiveness of a complex antihypertensive program in the elderly. Dis Manag 2004 7:235-243 | Clinical |
Glazener CM, Evans JH, Peto RE. Complex behavioural and educational interventions for nocturnal enuresis in children. Cochrane Database Syst Rev 2004 1:CD004668 | Health promotion |
Gülmezoglu AM, Villar J, Grimshaw J, Piaggio G, Lumbiganon P, Langer A. Cluster randomized trial of an active, multifaceted information dissemination intervention based on The WHO Reproductive health library to change obstetric practices: methods and design issues [ISRCTN14055385] BMC Med Res Methodol 2004 4:2 | Other |
Hammond A, Young A, Kidao R. A randomised controlled trial of occupational therapy for people with early rheumatoid arthritis. Ann Rheum Dis 2004 63:23-30 | Clinical |
Lawson H. The logic of collaboration in education and the human services. J Interprof Care 2004 18: 225-237 | Other |
Paterson C, Britten N. Acupuncture as a complex intervention: a holistic model. J Altern Complement Med 2004 10: 791-801 | Clinical |
Power R, Langhaug LF, Nyamurera T, Wilson D, Bassett MT, Cowan FM. Developing complex interventions for rigorous evaluation - a case study from rural Zimbabwe. Health Educ Res 2004 19:570-575 | Methodology |
Shemilt I, Harvey I, Shepstone L, Swift L, Reading R, Mugford M, Belderson P, Norris N, Thoburn J, Robinson J.A national evaluation of school breakfast clubs: evidence from a cluster randomized controlled trial and an observational analysis. Child Care Health Dev 2004 30: 413-427 | Health promotion |
Smith S, Bury, O’Leary M, Shannon W, Tynan A, Staines A, Thompson C. The North Dublin randomized controlled trial of structured diabetes shared care. Fam Pract 2004 21: 39-45 | Clinical |
Whitford DL, Roberts SH, Griffin S.Sustainability and effectiveness of comprehensive diabetes care to a district population. Diabet Med 2004 21: 1221-1228. | Clinical |
2005 | |
Bonetti D, Eccles M, Johnston M, Steen N, Grimshaw J, Baker R, Walker A, Pitts N. Guiding the design and selection of interventions to influence the implementation of evidence-based practice: an experimental simulation of a complex intervention trial. Soc Sci Med 2005 60:2135-2147 | Methodology |
Eldridge S, Spencer A, Cryer C, Parsons S, Underwood M, Feder G. Why modelling a complex intervention is an important precursor to trial design: lessons from studying an intervention to reduce falls-related injuries in older people. J Health Serv Res Policy 2005 10:133-142 | Methodology |
Greenhalgh T, Collard A, Begum N. Sharing stories: complex intervention for diabetes education in minority ethnic groups who do not speak English. BMJ 2005 330:628 | Health promotion |
Levesque L, .Guilbault G, Delormier T, Potvin L.Unpacking the black box: a deconstruction of the programming approach and physical activity interventions implemented in the Kahnawake Schools Diabetes Prevention Project. Health Promot Pract 2005 6:64-71 | Health promotion |
Nilsson S, Spak F, Marklund B, Baigi A, Allebeck P. Attitudes and behaviours with regards to androgenic anabolic steroids among male adolescents in a county of Sweden. Subst Use Misuse 2005 40:1-12 | Other |
Robinson L, Francis J, James P, Tindle N, Greenwell K, Rodgers H. Caring for carers of people with stroke: developing a complex intervention following the Medical Research Council framework. Clin Rehabil 2005 19:560-571 | Health promotion |
Rowlands G, Sims J, Kerry S. A lesson learnt: the importance of modelling in randomized controlled trials for complex interventions in primary care. Fam Pract 2005 22:132-139. | Methodology |
2006 | |
Blackwood B. Methodological issues in evaluating complex healthcare interventions. J Adv Nurs 2006 54:612-622 | Methodology |
Bower P, Gilbody S, Richards D, Fletcher J, Sutton A. Collaborative care for depression in primary care. Making sense of a complex intervention: systematic review and meta-regression. Br J Psychiatry 2006 189:484-493 | Clinical |
Byrne M, Cupples ME, Smith SM, Leathem C, Corrigan M, Byrne MC, Murphy AW. Development of a complex intervention for secondary prevention of coronary heart disease in primary care using the UK Medical Research Council framework. Am J Manag Care 2006 12:261-266 | Clinical |
Corrigan M, Cupples ME, Smith SM, Byrne M, Leathem CS, Clerkin P, Murphy AW. The contribution of qualitative research in designing a complex intervention for secondary prevention of coronary heart disease in two different healthcare systems. BMC Health Serv Res 2006 6:90 | Methodology |
Cullen W, Stanley J, Langton D, Kelly Y, Staines, A, Bury G. Hepatitis C infection among injecting drug users in general practice: a cluster randomised controlled trial of clinical guidelines’ implementation. Br J Gen Pract 2006 56:848-856 | Clinical |
Dornan T, Littlewood S, Margolis SA, Scherpbier A, Spencer J, Ypinazar V. How can experience in clinical and community settings contribute to early medical education? A BEME systematic review. Med Teach 2006 28:3-18 | Health promotion |
Greaves CJ, Farbus L. Effects of creative and social activity on the health and well-being of socially isolated older people: outcomes from a multi-method observational study. J R Soc Promot Health 2006 126:134-142 | Public health |
Heaven B, Murtagh M, Rapley T, May C, Graham R, Kaner E, Thomson R. Patients or research subjects? A qualitative study of participation in a randomised controlled trial of a complex intervention. Patient Educ Couns 2006 62:260-270 | Methodology |
Holbrook AM, Thabane L, Shcherbatykh IY, O'Reilly D. E-health interventions as complex interventions: improving the quality of methods of assessment. AMIA Annu Symp Proc 2006 AMIA 2006 Symposium Proceedings: 952 | Methodology |
Jansen YJ, Bal R, Bruijnzeels M, Foets M, Frenken R, de Bont A. Coping with methodological dilemmas; about establishing the effectiveness of interventions in routine medical practice. BMC Health Serv Res 2006 6:160 | Methodology |
Kasper J, Kopke S, Muhlhauser I, Heesen C.Evidence-based patient information about treatment of multiple sclerosis--a phase one study on comprehension and emotional responses. Patient Educ Couns 2006 62:56-63 | Health promotion |
Kunz R, Autti-Ramo I, Anttila H, Malmivaara A, Makela M. A systematic review finds that methodological quality is better than its reputation but can be improved in physiotherapy trials in childhood cerebral palsy. J Clin Epidemiol 2006 59:1239-1248 | Methodology |
MacPherson H, Thorpe L, Thomas K. Beyond needling - therapeutic processes in acupuncture care: a qualitative study nested within a low-back pain trial. J Altern Complement Med 2006 12:873-880 | Clinical |
Rapley T, May C, Heaven B, Murtagh M, Graham R, Kaner EF, Thomson R. Doctor-patient interaction in a randomised controlled trial of decision-support tools. Soc Sci Med 2006 62:2267-2278 | Methodology |
Salas I. Methodology for reorganization of the cervical cancer program in Chile. Cancer Detect Prev 2006 30:38-43 | Public health |
Sheik A, Baig K. An audit of the use and complications of glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention against national UK standards. Cardiovasc Revasc Med 2006 7:237-239 | Clinical |
Sisk JE, Hebert PL, Horowitz CR, McLaughlin MA, Wang JJ, Chassin MR. Effects of nurse management on the quality of heart failure care in minority communities: a randomized trial. Ann Intern Med 2006 145:273-283 | Clinical |
Sturt J, Hearnshaw H, Farmer A, Dale J, Eldridge S. The Diabetes Manual trial protocol - a cluster randomized controlled trial of a self-management intervention for type 2 diabetes [ISRCTN06315411]. BMC Fam Pract 2006 7:45 | Health promotion |
Sturt J, Taylor H, Docherty A, Dale J, Louise T.A psychological approach to providing self-management education for people with type 2 diabetes: the Diabetes Manual. BMC Fam Pract 2006 7:70 | Health promotion |
Sturt J, Whitlock S, Hearnshaw H. Complex intervention development for diabetes self-management. J Adv Nurs 2006 54:293-303 | Health promotion |
Treweek S, Sullivan F. How much does pre-trial testing influence complex intervention trials and would more testing make any difference? An email survey. BMC Med Res Methodol 2006 6:28 | Methodology |
2007 | |
Allegrante JP, Peterson MG, Cornell CN, MacKenzie CR, Robbins L, Horton R, Ganz SB, Ruchlin HS, Russo PW, Paget SA, Charlson ME. Methodological challenges of multiple-component intervention: lessons learned from a randomized controlled trial of functional recovery after hip fracture. HSS J 2007 3:63-70 | Methodology |
Armstrong N, Hearnshaw H, Powell J, Dale J.Stakeholder perspectives on the development of a virtual clinic for diabetes care: qualitative study. J Med Internet Res 2007 9:E23 | Health promotion |
Ciuffreda D, Pantaleo G, Pascual M. Effects of immunosuppressive drugs on HIV infection: implications for solid-organ transplantation. Transpl Int 2007 8:649-658 | Clinical |
Garfein RS, Swartzendruber A, Ouellet LJ, Kapadia F, Hudson SM, Thiede H, Strathdee SA, Williams IT, Bailey SL, Hagan H, Golub ET, Kerndt P, Hanson DL, Latka MH. Methods to recruit and retain a cohort of young-adult injection drug users for the Third Collaborative Injection Drug Users Study/Drug Users Intervention Trial (CIDUS III/DUIT).Drug Alcohol Depend 2007 91 Suppl 1:S4-17 | Methodology |
Green J, Jacobs B, Beecham J, Dunn G, Kroll L, Tobias C, Briskman J. Inpatient treatment in child and adolescent psychiatry - a prospective study of health gain and costs. J Child Psychol Psychiatry 2007 48:1259-1267 | Clinical |
Hoddinott P, Pill R, Chalmers M. Health professionals, implementation and outcomes: reflections on a complex intervention to improve breastfeeding rates in primary care. Fam Pract 2007 24:84-91 | Health promotion |
Lamb SE, Gates S, Underwood MR, Cooke MW, Ashby D, Szczepura A, Williams MA, Williamson EM, Withers EJ, Mt Isa S, Gumber A. Managing Injuries of the Neck Trial (MINT): design of a randomised controlled trial of treatments for whiplash associated disorders. BMC Musculoskelet Disord 2007 8:7 | Clinical |
MacPherson H, Schroer S. Acupuncture as a complex intervention for depression: a consensus method to develop a standardised treatment protocol for a randomised controlled trial. Complement Ther Med 2007 15:92-100 | Clinical |
May CR, Mair FS, Dowrick CF, Finch TL. Process evaluation for complex interventions in primary care: understanding trials using the normalization process model. BMC Fam Pract 2007 8:42 | Methodology |
Nardi R, Scanelli G, Corrao S, Iori I, Mathieu G, Cataldi Amatrian R. Co-morbidity does not reflect complexity in internal medicine patients. Eur J Intern Med 2007 18:359-368 | Clinical |
Paul G, Smith SM, Whitford D, O'Kelly F, O'Dowd T. Development of a complex intervention to test the effectiveness of peer support in type 2 diabetes. BMC Health Serv Res 2007 7:136 | Health promotion |
Paul GM, Smith SM, Whitford DL, O'Shea E, O'Kelly F, O'Dowd T. Peer support in type 2 diabetes: a randomised controlled trial in primary care with parallel economic and qualitative analyses: pilot study and protocol. BMC Fam Pract 2007 8:45 | Health promotion |
Peters-Klimm F, Muller-Tasch T, Schellberg D, Gensichen J, Muth C, Herzog W, Szecsenyi J.Rationale, design and conduct of a randomised controlled trial evaluating a primary care-based complex intervention to improve the quality of life of heart failure patients: HICMan (Heidelberg Integrated Case Management).BMC Cardiovasc Disord 2007 7:25 | Clinical |
Power R, Langhaug L, Cowan F. "But there are no snakes in the wood": risk mapping as an outcome measure in evaluating complex interventions. Sex Transm Infect 2007 83:232-236 | Methodology |
Protheroe J, Bower P, Chew-Graham C. The use of mixed methodology in evaluating complex interventions: identifying patient factors that moderate the effects of a decision aid. Fam Pract 2007 24:594-600 | Methodology |
Protopopoff N, Van Herp M, Maes P, Reid T, Baz D, D'Alessandro U, Van Bortel W, Coosemans M. Vector control in a malaria epidemic occurring within a complex emergency situation in Burundi: a case study. Malar J 2007 6:93 | Public health |
Qian X, Smith H, Huang W, Zhang J, Huang Y, Garner P. Promoting contraceptive use among unmarried female migrants in one factory in Shanghai: a pilot workplace intervention. BMC Health Serv Res 2007 7:77 | Health promotion |
Spillane V, Byrne MC, Byrne, M Leathem CS, O'Malley M, Cupples ME. Monitoring treatment fidelity in a randomized controlled trial of a complex intervention. J Adv Nurs 2007 60:343-352 | Methodology |
Turner DE, Helliwell PS, Woodburn J.Methodological considerations for a randomised controlled trial of podiatry care in rheumatoid arthritis: lessons from an exploratory trial. BMC Musculoskelet Disord 2007 8:109 | Methodology |
Wang HE, Abo BN, Lave JR, Yealy DM. How would minimum experience standards affect the distribution of out-of-hospital endotracheal intubations? Ann Emerg Med 2007 50:246-252 | Clinical |
Wiener-Ogilvie S, Pinnock H, Huby G, Sheikh A, Partridge MR, Gillies J. Do practices comply with key recommendations of the British Asthma Guideline? If not, why not? Prim Care Respir J 2007 16: 369-377 | Clinical |
2008 | |
Abelson JL, Khan S, Liberzon I, Erickson TM, Young EA. Effects of perceived control and cognitive coping on endocrine stress responses to pharmacological activation. Biol Psychiatry 2008 64:701-707 | Clinical |
Bosch-Capblanch X, Garner P. Primary health care supervision in developing countries. Trop Med Int Health 2008 13: 369-383 | Other |
Byng R, Norman I, Redfern S, Jones R. Exposing the key functions of a complex intervention for shared care in mental health: case study of a process evaluation. BMC Health Serv Res 2008 8:274 | Methodology |
Carrasco MP, Salvador CH, Sagredo PG, Marquez-Montes J, Gonzalez de Mingo MA, Fragua JA, Rodriguez MC, Garcia-Olmos LM, Garcia-Lopez F, Carrero AM, Monteagudo JL. Impact of patient-general practitioner short-messages-based interaction on the control of hypertension in a follow-up service for low-to-medium risk hypertensive patients: a randomized controlled trial. IEEE Trans Inf Technol Biomed 2008 12:780-791 | Clinical |
de Salis I, Tomlin Z, Toerien M, Donovan J. Using qualitative research methods to improve recruitment to randomized controlled trials: the Quartet study. J Health Serv Res Policy 2008 13 Suppl 3:92-96 | Methodology |
de Salis I, Tomlin Z, Toerien M, Donovan J. Qualitative research to improve RCT recruitment: issues arising in establishing research collaborations. Contemp Clin Trials 2008 29:663-670 | Methodology |
Eisenberg ML, Elliott SP, McAninch JW. Management of restenosis after urethral stent placement. J Urol 2008 179:991-5 | Clinical |
Fairall LR, Bachmann MO, Zwarenstein MF, Lombard CJ, Uebel K, van Vuuren C, Steyn D, Boulle A, Bateman ED. Streamlining tasks and roles to expand treatment and care for HIV: randomised controlled trial protocol. Trials 2008 9:21 | Clinical |
Fearon KC. Cancer cachexia: developing multimodal therapy for a multidimensional problem. Eur J Cancer 2008 44:1124-32 | Clinical |
Hawe P, Shiell A, Riley T. In response to Spillane V., Byrne M.C., Byrne M., Leathem C.S., O'Malley M. & Cupples M.E. (2007) Monitoring treatment fidelity in a randomized trial of a complex intervention. Journal of Advanced Nursing 60 (3) , 343-352. Important considerations for standardizing complex interventions. J Adv Nurs 2008 62:267 | Methodology |
Hendriks MR, Bleijlevens MH, van Haastregt JC, Bruijn FH, Diederiks JP, Mulder WJ, Ruijgrok JM, Stalenhoef PA, Crebolder HF,van Eijk JT. A multidisciplinary fall prevention program for elderly persons: a feasibility study. Geriatr Nurs 2008 29:186-196 | Health promotion |
Karamanidou C, Weinman J, Horne R. Improving haemodialysis patients' understanding of phosphate-binding medication: a pilot study of a psycho-educational intervention designed to change patients' perceptions of the problem and treatment. Br J Health Psychol 2008 13:205-214 | Health promotion |
Klinkhammer-Schalke M, Koller M, Ehret C, Steinger B, Ernst B, Wyatt JC, Hofstadter F, Lorenz W. Implementing a system of quality-of-life diagnosis and therapy for breast cancer patients: results of an exploratory trial as a prerequisite for a subsequent RCT. Br J Cancer 2008 99:415-422 | Clinical |
Klinkhammer-Schalke M, Koller M, Wyatt JC, Steinger B, Ehret C, Ernst B, Hofstadter F, Lorenz W. Quality of life diagnosis and therapy as complex intervention for improvement of health in breast cancer patients: delineating the conceptual, methodological, and logistic requirements (modelling). Langenbecks Arch Surg 2008 393:1-12 | Methodology |
MacPherson H, Nahin R, Paterson C, Cassidy CM, Lewith GT, Hammerschlag R. Developments in acupuncture research: big-picture perspectives from the leading edge. J Altern Complement Med 2008 14:883-887 | Methodology |
MacPherson H, Thomas K. Self-help advice as a process integral to traditional acupuncture care: implications for trial design. Complement Ther Med 2008 16:101-106 | Health promotion |
Narahari SR, Ryan TJ, Aggithaya MG, Bose KS, Prasanna KS. Evidence-based approaches for the Ayurvedic traditional herbal formulations: toward an Ayurvedic CONSORT model. J Altern Complement Med 2008 14:769-776 | Methodology |
Panella M, Marchisio S, Gardini A, Di Stanislao F. A cluster randomized controlled trial of a clinical pathway for hospital treatment of heart failure: study design and population. BMC Health Serv Res 2008 7:179 | Clinical |
Panella M, Brambilla R, Marchisio S, Di Stanislao F. Reducing stroke in-hospital mortality: organized care is a complex intervention. Stroke 2008 39:e186 | Clinical |
Patel VH, Kirkwood BR, Pednekar, S, Araya R, King M, Chisholm D, Simon G, Weiss H. Improving the outcomes of primary care attenders with common mental disorders in developing countries: a cluster randomized controlled trial of a collaborative stepped care intervention in Goa, India. Trials 2008 9:4 | Clinical |
Perkins D, Harris MF, Tan J, Christl B, Taggart J, Fanaian M. Engaging participants in a complex intervention trial in Australian General Practice. BMC Med Res Methodol 2008 8:55 | Methodology |
Sampson EL, Thune-Boyle I, Kukkastenvehmas R, Jones L, Tookman A, King M, Blanchard MR. Palliative care in advanced dementia; a mixed methods approach for the development of a complex intervention. BMC Palliat Care 2008 7:8 | Clinical |
Sifri ZC, Kim H, Lavery R, Mohr A, Livingston DH. The impact of obesity on the outcome of emergency intubation in trauma patients. J Trauma 2008 65:396-400 | Clinical |
Strong V, Waters R, Hibberd C, Murray G, Wall L, Walker J, McHugh G, Walker A, Sharpe M. Management of depression for people with cancer (SMaRT oncology 1) : a randomised trial. Lancet 2008 372:40-48 | Clinical |
Tee A, Calzavacca P, Licari E, Goldsmith D, Bellomo R. Bench-to-bedside review: the MET syndrome -the challenges of researching and adopting medical emergency teams. Crit Care 2008 12:205 | Clinical |
Vaessen J, Todd D. Methodological challenges of evaluating the impact of the Global Environment Facility's biodiversity program. Eval Program Plann 2008 31:231-240 | Methodology |
Wille N, Bettge S, Ravens-Sieberer U. Risk and protective factors for children's and adolescents' mental health: results of the BELLA study. Eur Child Adolesc Psychiatry 2008 17 Suppl 1:133-147 | Health promotion |
Wilson PM. The UK Expert Patients Program: lessons learned and implications for cancer survivors' self-care support programs. J Cancer Surviv 2008 2:45-52 | Health promotion |
2009 | |
Avery AJ, Rodgers S, Cantrill JA, Armstrong S, Elliott R, Howard R, Kendrick D, Morris CJ, Murray SA, Prescott RJ, Cresswell K, Sheikh A. Protocol for the PINCER trial: a cluster randomised trial comparing the effectiveness of a pharmacist-led IT-based intervention with simple feedback in reducing rates of clinically important errors in medicines management in general practices. Trials 2009 10:28 | Health promotion |
Blackberry ID, Furler JS, Young D, Best JD.What does it cost to establish a practice-nurses-led clinical trial in general practice? Med J Aust 2009 191: 492-495 | Methodology |
Bovend'Eerdt TJ, Botell RE, Wade DT. Writing SMART rehabilitation goals and achieving goal attainment scaling: a practical guide. Clin Rehabil 2009 23:352-361 | Clinical |
Cagle JG, Kovacs PJ. Education: a complex and empowering social work intervention at the end of life. Health Soc Work 2009 34:17-27 | Health promotion |
Colombet I, Sabatier B, Gillaizeau F, Prognon P, Begue , Durieux P. Long-term effects of a multifaceted intervention to encourage the choice of the oral route for proton pump inhibitors: an interrupted time-series analysis. Qual Saf Health Care 2009 18:232-235 | Health promotion |
Conboy L, Edshteyn I, Garivaltis H. Ayurveda and Panchakarma: measuring the effects of a holistic health intervention. ScientificWorldJournal 2009 9:272-280 | Clinical |
Connolly M, Grimshaw J, Dodd M, Cawthorne J, Hulme T, Everitt S, Tierney S, Deaton C. Systems and people under pressure: the discharge process in an acute hospital. J Clin Nurs 2009 18:4 | Clinical |
Donovan JL, Lane JA, Peters TJ, Brindle L, Salter E, Gillatt D, Powell P, Bollina P, Neal DE, Hamdy FC. Development of a complex intervention improved randomization and informed consent in a randomized controlled trial. J Clin Epidemiol 2009 62:29-36 | Clinical |
Dumont A, Fournier P, Fraser W, Haddad S, Traore M, Diop I, Gueye M, Gaye A, Couturier F, Pasquier, JC, Beaudoin F, Lalonde A, Hatem, M, Abrahamowicz, M. QUARITE (quality of care, risk management and technology in obstetrics): a cluster-randomized trial of a multifaceted intervention to improve emergency obstetric care in Senegal and Mali. Trials 2009 10:85 | Clinical |
Dyas JV, Apekey T, Tilling M, Siriwardena AN. Strategies for improving patient recruitment to focus groups in primary care: a case study reflective paper using an analytical framework. BMC Med Res Methodol 2009 9:65 | Methodology |
Farquhar MC, Higginson IJ, Fagan P, Booth S. The feasibility of a single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease. BMC Palliat Care 2009 8:9 | Clinical |
Holle R, Grassel E, Ruckdaschel S, Wunder S, Mehlig H, Marx P, Pirk O, Butzlaff M, Kunz S, Lauterberg J. Dementia care initiative in primary practice: study protocol of a cluster randomized trial on dementia management in a general practice setting. BMC Health Serv Res 2009 9:91 | Clinical |
King M, Jones L, McCarthy, O, Rogers M, Richardson A, Williams R, Tookman A, Nazareth I. Development and pilot evaluation of a complex intervention to improve experienced continuity of care in patients with cancer. Br J Cancer 2009 100:274-280 | Clinical |
Mao J, Hou Y, Shang H, Wang H, Wang X, Zhao Y, Niu T, Cui J, Li G, Lin Q, Shi L, Jia X, Fan R, Wang B, Ruan J. Study on the evaluation of the clinical effects of traditional chinese medicine in heart failure by complex intervention: protocol of SECETCM-HF. Trials 2009 10:122 | Clinical |
Mesotten D, Van den Berghe G. Clinical benefits of tight glycaemic control: focus on the intensive care unit. Best Pract Res Clin Anaesthesiol 2009 23:421-429 | Clinical |
Murphy AW, Cupples ME, Smith SM, Byrne M, Byrne MC, Newell J. Effect of tailored practice and patient care plans on secondary prevention of heart disease in general practice: cluster randomised controlled trial. 2009 BMJ 339:b4220 | Clinical |
Richards D A, Hughes-Morley A, Hayes RA, Araya R, Barkham M, Bland JM, Bower P, Cape J, Chew-Graham C A, Gask L, Gilbody S, Green C, Kessler D, Lewis G, Lovell K, Manning C, Pilling S. Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression - study protocol. BMC Health Serv Res 2009 9:188 | Clinical |
Rickles D. Causality in complex interventions. Med Health Care Philos 2009 12:77-90 | Methodology |
Schmidt-Kraepelin C, Janssen B, Gaebel W. Prevention of rehospitalization in schizophrenia: results of an integrated care project in Germany. Eur Arch Psychiatry Clin Neurosci 2009 259 Suppl 2:S205-12 | Clinical |
Schroer S, MacPherson H, Adamson J. Designing an RCT of acupuncture for depression--identifying appropriate patient groups: a qualitative study. Fam Pract 2009 26: 188-195 | Clinical |
Seers HE, Gale N, Paterson C, Cooke HJ, Tuffrey V, Polley MJ. Individualised and complex experiences of integrative cancer support care: combining qualitative and quantitative data. Support Care Cancer 2009 17:1159-1167 | Clinical |
Simon S, Higginson I J. Evaluation of hospital palliative care teams: strengths and weaknesses of the before-after study design and strategies to improve it. Palliat Med 2009 23:23-28 | Clinical |
Simpson SA, Butler CC, Hood K, Cohen D, Dunstan F, Evans MR, Rollnick S, Moore L, Hare M, Bekkers MJ, Evans J. Stemming the Tide of Antibiotic Resistance (STAR): a protocol for a trial of a complex intervention addressing the 'why' and 'how' of appropriate antibiotic prescribing in general practice. BMC Fam Pract 2009 10:20 | Clinical |
Siriwardena AN, Apekey T, Tilling M, Harrison A, Dyas JV, Middleton HC, Orner R, Sach T, Dewey M, Qureshi ZM. Effectiveness and cost-effectiveness of an educational intervention for practice teams to deliver problem focused therapy for insomnia: rationale and design of a pilot cluster randomised trial. BMC Fam Pract 2009 10:9 | Health promotion |
Suh JW, Kim SY, Park JS, Kim YS, Kang HJ, Koo BK, Kim HS. Comparison of triple antiplatelet therapy including triflusal and conventional dual therapy in patients who underwent drug-eluting stent implantation. Int Heart J 2009 50:701-709 | Clinical |
Thompson DR, Clark AM. Cardiac rehabilitation: into the future. Heart 2009 95:1897-1900 | Clinical |
Thompson EA, Relton C. Designing clinical trials of homeopathy for menopausal symptoms: a review of the literature. Menopause Int 2009 15:31-34 | Clinical |
Walker J, Cassidy J, Sharpe M. The second Symptom Management Research Trial in Oncology (SMaRT Oncology-2): a randomised trial to determine the effectiveness and cost-effectiveness of adding a complex intervention for major depressive disorder to usual care for cancer patients. Trials 2009 10:18 | Clinical |
Walker J, Cassidy J, Sharpe M. The third symptom management research trial in oncology (SMaRT oncology- 3) : a randomised trial to determine the efficacy of adding a complex intervention for major depressive disorder (depression care for people with lung cancer) to usual care, compared to usual care alone in patients with lung cancer. Trials 2009 10:92 | Clinical |
2010 | |
Ali M, Ashburn A, Bowen A, Brodie E, Corr S, Drummond A, Edmans J, Gladman, J, Kalra L, Langhorne P, Lees KR, Lincoln N, Logan P, Mead G, Patchick E, Pollock A, Pomeroy V, Sackley C, Sunnerhagen K S, van Vliet P, Walker M, Brady M. VISTA-Rehab: a resource for stroke rehabilitation trials. Int J Stroke 2010 5:447-52 | Methodology |
Amặlinei C, Caruntu ID, Giusca, SE, Balan, RA. Matrix metalloproteinases involvement in pathologic conditions. Rom J Morphol Embryol 2010 51:215-28 | Clinical |
Cameron ID. Models of rehabilitation - commonalities of interventions that work and of those that do not. Disabil Rehabil 2010 32:1051-1058 | Methodology |
Cousins K, Connor JL, Kypri K. Reducing alcohol-related harm and social disorder in a university community: a framework for evaluation. Inj Prev 2010 16:e1-6 | Health promotion |
Craig LE, Bernhardt J, Langhorne P, Wu O. Early mobilization after stroke: an example of an individual patient data meta-analysis of a complex intervention. Stroke 2010 41:2632-2636 | Clinical |
de Vlaming R, Haveman-Nies A, Van't Veer P, de Groot LC. Evaluation design for a complex intervention program targeting loneliness in non-institutionalized elderly Dutch people. BMC Public Health 2010 10:552 | Public health |
Dorresteijn JA, Kriegsman DM, Valk GD. Complex interventions for preventing diabetic foot ulceration. Cochrane Database Syst Rev 2010 CD007610 | Clinical |
Emsley R, Dunn G, White IR. Mediation and moderation of treatment effects in randomised controlled trials of complex interventions. Stat Methods Med Res 2010 19:237-70 | Methodology |
Farquhar M, Higginson IJ, Fagan P, Booth S. Results of a pilot investigation into a complex intervention for breathlessness in advanced chronic obstructive pulmonary disease (COPD): brief report. Palliat Support Care 2010 8:143-149 | Clinical |
Hill GM, Sowden JM, Lister RK, Logan, RA, Finlay AY. Dermatology outpatient case-mix survey for all Welsh Trusts, 2007. Br J Dermatol 2010 162:152-158 | Clinical |
Hoddinott P, Britten J, Pill R. Why do interventions work in some places and not others: a breastfeeding support group trial. Soc Sci Med 2010 70:769-778 | Health promotion |
Horsburgh M, Goodyear-Smith F, Bycroft J, Mahony, F, Roy D, Miller D, Donnell E. Lessons learnt from attempting to assess the evidence base for a complex intervention introduced into New Zealand general practice. Qual Saf Health Care 2010 19:e50 | Methodology |
Hunter B, Segrot J. Using a clinical pathway to support normal birth: impact on practitioner roles and working practices. Birth 2010 37:227-236 | Clinical |
Hutchinson C, Lange I, Kanhonou L, Filippi V, Borchert M. Exploring the sustainability of obstetric near-miss case reviews: a qualitative study in the South of Benin. Midwifery 2010 26:537-543 | Methodology |
Jiwa M, Mitchell G, Sibbrit D, Girgis A, Burridge L. Addressing the needs of caregivers of cancer patients in general practice: a complex intervention. Qual Prim Care 2010 18:9-16 | Health promotion |
Kirkegaard P, Edwards G, Hansen B, Hansen MD, Jensen MS, Lauritzen T, Risoer MB, Thomsen JL. The RISAP-study: a complex intervention in risk communication and shared decision-making in general practice. BMC Fam Pract 2010 11:70 | Health promotion |
Korb-Savoldelli V, Sabatier B, Gillaizeau F, Guillemain R, Prognon P, Begue D, Durieux P. Non-adherence with drug treatment after heart or lung transplantation in adults: a systematic review. Patient Educ Couns 2010 81:148-154 | Clinical |
Langhorne P, Lewsey JD, Jhund PS, Gillies M, Chalmers JW, Redpath A, Briggs A, Walters M, Capewell S, McMurray JJ, MacIntyre K. Estimating the impact of stroke unit care in a whole population: an epidemiological study using routine data. J Neurol Neurosurg Psychiatry 2010 81:1301-1305 | Clinical |
Mayer S, Weisser M, Till H, Grafe G, Geyer C. Congenital myelomeningocele - do we have to change our management? Cerebrospinal Fluid Res 2010 7:17 | Clinical |
McKibbon KA, Lokker, C, Wilczynski NL, Ciliska D, Dobbins M, Davis DA, Haynes RB, Straus SE. A cross-sectional study of the number and frequency of terms used to refer to knowledge translation in a body of health literature in 2006: a Tower of Babel? Implement Sci 2010 5:16 | Methodology |
Murray, E. Treweek, S. Pope, C. MacFarlane, A. Ballini, L. Dowrick, C. Finch, T. Kennedy, A. Mair, F. O'Donnell, C. Ong, B. N. Rapley, T. Rogers, A. May, C. Normalisation process theory: a framework for developing, evaluating and implementing complex interventions. BMC Med 2010 8:63 | Methodology |
O'Carroll, R. Dennis, M. Johnston, M. Sudlow, C. Improving adherence to medication in stroke survivors (IAMSS): a randomised controlled trial: study protocol. BMC Neurol 2010 10:15 | Clinical |
Reavley N, Livingston J, Buchbinder R, Bennell K, Stecki C, Osborne RH. A systematic grounded approach to the development of complex interventions: the Australian Work Health Program--arthritis as a case study. Soc Sci Med 2010 70:342-350 | Health promotion |
Sankaran S, Kenealy T, Adair A, Adair V, Coster H, Whitehead N, Sheridan N, Parsons M, Marshall E, Bailey L, Price C, Crombie D, Rea H. A complex intervention to support 'rest home' care: a pilot study. N Z Med J 2010 123:41-53 | Health promotion |
Siddiqi K, Khan A, Ahmad M, Shafiq-ur-Rehman. An intervention to stop smoking among patients suspected of TB - evaluation of an integrated approach. BMC Public Health 2010 10:160 | Health promotion |
Sollid SJ, Lossius HM, Nakstad AR, Aven T, Soreide E. Risk assessment of pre-hospital trauma airway management by anaesthesiologists using the predictive Bayesian approach. Scand J Trauma Resusc Emerg Med 2010 18:22 | Clinical |
Song J, Ratner ER, Wall MM, Bartels DM, Ulvestad N, Petroskas D, West M, Weber-Main AM, Grengs L, Gelberg L. Effect of an end-of-life planning intervention on the completion of advance directives in homeless persons: a randomized trial. Ann Intern Med 2010 153:76-84 | Health promotion |
Thompson A, Sullivan S, Barley M, Moore L, Rogers P, Sipos A, Harrison G. Effectiveness of a cognitive behavioural workbook for changing beliefs about antipsychotic polypharmacy: analysis from a cluster randomized controlled trial. J Eval Clin Pract 2010 16:520-528 | Health promotion |
Thompson EA. Alternative and complementary therapies for the menopause: a homeopathic approach. Maturitas 2010 66:350-354 | Clinical |
Van Herck P, Vanhaecht K, Deneckere S, Bellemans J, Panella M, Barbieri A, Sermeus W. Key interventions and outcomes in joint arthroplasty clinical pathways: a systematic review. J Eval Clin Pract 2010 16:39-49 | Clinical |
Vanhaecht K, Sermeus W, Peers J, Lodewijckx C, Deneckere S, Leigheb F, Decramer M, Panella M. The impact of care pathways for exacerbation of Chronic Obstructive Pulmonary Disease: rationale and design of a cluster randomized controlled trial. Trials 2010 11:111 | Clinical |
Walker J, Fairley CK, Walker SM, Gurrin L C, Gunn JM, Pirotta MV, Carter R, Hocking JS. Computer reminders for Chlamydia screening in general practice: a randomized controlled trial. Sex Transm Dis 2010 37:445-450 | Health promotion |
2011 | |
Barasa EW, English M. Economic evaluation of package of care interventions employing clinical guidelines. Trop Med Int Health 2011 16:97-104 | Methodology |
Barker M, Baird J, Lawrence W, Jarman M, Black C, Barnard K, Cradock S, Davies J, Margetts B Inskip H, Cooper C. The Southampton Initiative for Health: a complex intervention to improve the diets and increase the physical activity levels of women from disadvantaged communities. J Health Psychol 2011 16:178-191 | Health promotion |
Begh RA, Aveyard P, Upton P, Bhopal RS, White M, Amos A, Prescott RJ, Bedi R, Barton PM, Fletcher M, Gill P, Zaidi Q, Sheikh A. Experiences of outreach workers in promoting smoking cessation to Bangladeshi and Pakistani men: longitudinal qualitative evaluation. BMC Public Health 2011 11:452 | Health promotion |
Bennell KL, Egerton T, Pua YH, Abbott JH, Sims K, Buchbinder R. Building the rationale and structure for a complex physical therapy intervention within the context of a clinical trial: a multimodal individualized treatment for patients with hip osteoarthritis. Phys Ther 2011 91:1525-1541 | Clinical |
Bird L, Arthur A, Cox K. "Did the trial kill the intervention?" experiences from the development, implementation and evaluation of a complex intervention. BMC Med Res Methodol 2011 11:24 | Clinical |
Boase S, Kim Y, Craven A, Cohn S. Involving practice nurses in primary care research: the experience of multiple and competing demands. J Adv Nurs 2011 68:590-599 | Methodology |
Borglin G, Gustafsson M, Krona H. A theory-based educational intervention targeting nurses' attitudes and knowledge concerning cancer-related pain management: a study protocol of a quasi-experimental design. BMC Health Serv Res 2011 11:233 | Clinical |
Brady MC, Stott DJ, Norrie J, Chalmers C, St George B, Sweeney PM, Langhorne P. Developing and evaluating the implementation of a complex intervention: using mixed methods to inform the design of a randomised controlled trial of an oral healthcare intervention after stroke. Trial 2011 12:168 | Clinical |
Braun SM, Wade DT, Beurskens AJ. Use of movement imagery in neurorehabilitation: researching effects of a complex intervention. Int J Rehabil Res 2011 34:203-208 | Clinical |
Burr JM, Campbell MK, Campbell SE, Francis JJ, Greene A, Hernandez R, Hopkins D, McCann SK, Vale LD. Developing the clinical components of a complex intervention for a glaucoma screening trial: a mixed methods study. BMC Med Res Methodol 2011 11:54 | Clinical |
Carter G, Britton B, Clover K, Rogers K, Adams C, McElduff P. Effectiveness of QUICATOUCH: a computerised touch screen evaluation for pain and distress in ambulatory oncology patients in Newcastle, Australia. Psycho-Oncology 2011 DOI:10.1002/pon.2020 | Clinical |
Charles JM, Bywater T, Edwards RT. Parenting interventions: a systematic review of the economic evidence. Child Care Health Dev 2011 37:462-474 | Health promotion |
Christie D, Hudson L, Mathiot A, Cole TJ, Karlsen S, Kessel A, Kinra S, Morris S, Nazareth I, Sovio U, Wong IC, Viner RM. Assessing the efficacy of the healthy eating and lifestyle programme (HELP) compared with enhanced standard care of the obese adolescent in the community: study protocol for a randomized controlled trial. Trials 2011 12:242 | Health promotion |
Costantini M, Ottonelli S, Canavacci L, Pellegrini F, Beccaro M. The effectiveness of the Liverpool care pathway in improving end of life care for dying cancer patients in hospital. A cluster randomised trial. BMC Health Serv Res 2011 11:13 | Clinical |
Dowding DW, Cheyne HL, Hundley V. Complex interventions in midwifery care: reflections on the design and evaluation of an algorithm for the diagnosis of labour. Midwifery 2011 27:654-659 | Methodology |
Dunn G, Fowler D, Rollinson R, Freeman D, Kuipers E, Smith B, Steel C, Onwumere J, Jolley S, Garety P, Bebbington P. Effective elements of cognitive behaviour therapy for psychosis: results of a novel type of subgroup analysis based on principal stratification. Psychol Med 2011 DOI: 10.1017/S0033291711001954 | Clinical |
Edwards ED, Mason BW, Oliver A, Powell CV. Cohort study to test the predictability of the Melbourne criteria for activation of the medical emergency team. Arch Dis Child 2011 96:174-179 | Clinical |
Farquhar MC, Ewing G, Booth S. Using mixed methods to develop and evaluate complex interventions in palliative care research. Palliat Med 2011 25:748-757 | Methodology |
Farquhar MC, Prevost AT, McCrone P, Higginson IJ, Gray J, Brafman-Kennedy B, Booth S. Study protocol: Phase III single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease. Trials 2011 12:130 | Clinical |
Forster DA, Newton M, McLachlan HL, Willis K. Exploring implementation and sustainability of models of care: can theory help? BMC Public Health 2011 11 (Suppl 5): S8 | Methodology |
Gask L, Dowrick C, Salmon P, Peters S, Morriss R. Reattribution reconsidered: narrative review and reflections on an educational intervention for medically unexplained symptoms in primary care settings. J Psychosom Res 2011 71:325-334 | Methodology |
Greenhalgh T, Campbell-Richards D, Vijayaraghavan S, Collard A, Malik F, Griffin M, Morris J, Claydon A, Macfarlane F. New models of self-management education for minority ethnic groups: pilot randomized trial of a story-sharing intervention. J Health Serv Res Policy 2011 16:28-36 | Health promotion |
Gustafsson L, Nugent N, Biros L. Occupational therapy practice in hospital-based stroke rehabilitation? Scand J Occup Ther 2011 DOI: 10.3109/11038128 | Clinical |
Haire BG. Because we can: clashes of perspective over researcher obligation in the failed PrEP trials. Dev World Bioeth 2011 11:63-74 | Methodology |
Hansen DG, Bergholdt SH, Holm L, Kragstrup J, Bladt T,Sondergaard J. A complex intervention to enhance the involvement of general practitioners in cancer rehabilitation. Protocol for a randomised controlled trial and feasibility study of a multimodal intervention. Acta Oncol 2011 50:299-306 | Clinical |
Hirsch O, Keller H, Krones T, Donner-Banzhoff N. Acceptance of shared decision making with reference to an electronic library of decision aids (arriba-lib) and its association to decision making in patients: an evaluation study. Implement Sci 2011 6:70 | Health promotion |
James DM. The applicability of normalisation process theory to speech and language therapy: a review of qualitative research on a speech and language intervention. Implement Sci 2011 6:95 | Methodology |
Kearns A, Whitley E, Mason P, Petticrew M, Hoy C. Material and meaningful homes: mental health impacts and psychosocial benefits of rehousing to new dwellings. Int J Public Health 2011 56:597-607 | Public health |
Kirkevold M, Bronken BA, Martinsen R, Kvigne K. Promoting psychosocial well-being following a stroke: Developing a theoretically and empirically sound complex intervention. Int J Nurs Stud 2011 DOI: 10.1016/j.ijnurstu | Health promotion |
Lee MS, Choi TY,Kim JI, Kim L, Ernst E. Acupuncture for treating attention deficit hyperactivity disorder: a systematic review and meta-analysis. Chin J Integr Med 2011 17:257-260 | Clinical |
Lossius HM, Sollid SJ, Rehn M, Lockey DJ. Revisiting the value of pre-hospital tracheal intubation: an all time systematic literature review extracting the Utstein airway core variables. Crit Care 2011 15:R26 | Clinical |
Maratos A, Crawford MJ, Procter S. Music therapy for depression: it seems to work, but how? Br J Psychiatry 2011 199:92-93 | Clinical |
Mayo NE, Scott S. Evaluating a complex intervention with a single outcome may not be a good idea: an example from a randomised trial of stroke case management. Age Ageing 2011 40:718-724 | Clinical |
McLean S, Nurmatov U, Liu JL, Pagliari C, Car J,Sheikh A. Telehealthcare for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2011 DOI: 10.1002/14651858.CD007718.pub2. | Clinical |
McQuay H. Evidence-based medicine: what is the evidence that it has made a difference? Palliat Med 2011 25:394-397 | Methodology |
Melis RJ, Teerenstra S,Olde Rikkert MG, Borm GF. Pseudo cluster randomization: balancing the disadvantages of cluster and individual randomization. Eval Health Prof 2011 34:151-163 | Methodology |
Milanese S. The use of RCT's in manual therapy-- are we trying to fit a round peg into a square hole? Man Ther 2011 16:403-405 | Methodology |
Morrison JJ, Mellor A, Midwinter M, Mahoney PF, Clasper JC. Is pre-hospital thoracotomy necessary in the military environment? Injury 2011 42:469-473 | Clinical |
Ogilvie D, Bull F, Powell J, Cooper AR, Brand C, Mutrie N, Preston J, Rutter H. An applied ecological framework for evaluating infrastructure to promote walking and cycling: the iConnect study. Am J Public Health 2011 101:473-481 | Public health |
Price S, Long AF, Godfrey M, Thomas KJ. Getting inside acupuncture trials--exploring intervention theory and rationale. BMC Complement Altern Med 2011 11:22 | Methodology |
Sampson EL, Jones L, Thune-Boyle IC, Kukkastenvehmas R, King M, Leurent B, Tookman A, Blanchard MR. Palliative assessment and advance care planning in severe dementia: an exploratory randomized controlled trial of a complex intervention. Palliat Med 2011 25:197-209 | Clinical |
Schiapparelli P, Allais G, Rolando S, Airola G, Borgogno P, Terzi MG, Benedetto C. Acupuncture in primary headache treatment. Neurol Sci 2011 32 Suppl 1:S15-8 | Clinical |
Schroer S, Adamson J. Acupuncture for depression: a critique of the evidence base. CNS Neurosci Ther 2011 17: 398-410 | Methodology |
Senn B, Kirsch M, Sanz CC, Karlou C, Tulus K, De Leeuw J, Ringner A, Goossens GA, Cleary V. How cancer research could benefit from the Complex Intervention Framework: students' experiences of the European Academy of Nursing Science summer school. Eur J Cancer Care (Engl) 2011 20:1-4 | Methodology |
Siddiqi N, Young J, House AO, Featherstone I, Hopton A, Martin C, Edwards J, Krishnan R, Peacock R, Holt R. Stop Delirium! A complex intervention to prevent delirium in care homes: a mixed-methods feasibility study. Age Ageing 2011 40:90-98 | Clinical |
Wallcraft J. The person in health care policy development. J Eval Clin Pract 2011 17:347-349 | Public health |
Young K, Bunn F, Trivedi D, Dickinson A. Nutritional education for community dwelling older people: a systematic review of randomised controlled trials. Int J Nurs Stud 2011 48:751-780 | Health promotion |