Skip to main content

Table 1 Papers analysed by year of publication

From: Challenges to evaluating complex interventions: a content analysis of published papers

Loeb MB. Application of the development stages of a cluster randomized trial to a framework for valuating complex health interventions. BMC Health Serv Res 2002 2:13 Methodology
Műhlhauser I, Berger, M. Patient education - evaluation of a complex intervention. Diabetologia 2002 45:1723-1733 Health promotion
Nazareth I, Freemantle N, Duggan C, Mason J, Haines, A. Evaluation of a complex intervention for changing professional behaviour: the Evidence Based Out Reach (EBOR) Trial. J Health Serv Res Policy 2002 7:230-238 Health promotion
Treweek SP, Glenton C, Oxman AD, Penrose A. Computer-generated patient education materials: do they affect professional practice? A systematic review. 2002 J Am Med Inform Assoc 4:346-358 Health promotion
Emery JD. Effect of computerised evidence based guidelines. BMJ 2003 326:394 Methodology
Glazener CM, Evans JH, Peto RE. Tricyclic and related drugs for nocturnal enuresis in children. Cochrane Database Syst Rev 2003 3:CD002117 Clinical
Lyles JS, Hodges A, Collins C, Lein C, Given CW, Given B, D'Mello D, Osborn GG, Goddeeris J, Gardiner JC, Smith RC. Using nurse practitioners to implement an intervention in primary care for high-utilizing patients with medically unexplained symptoms. Gen Hosp Psychiatry 2003 25:63-73 Clinical
Omar R. The evidence for prosthodontic treatment planning for older, partially dentate patients. Med Princ Pract 2003 12 Suppl 1:33-42 Clinical
Rollnick S. General practitioner screening for excessive alcohol use. Paper enables open debate about a complex intervention. BMJ 2003 326:336 Health promotion
Byng R, Jones R. Mental Health Link: the development and formative evaluation of a complex intervention to improve shared care for patients with long-term mental illness. J Eval Clin Pract 2004 10:27-36 Methodology
Conway TL, Woodruff SI, Edwards CC, Hovell MF, Klein J. Intervention to reduce environmental tobacco smoke exposure in Latino children: null effects on hair biomarkers and parent reports. Tob Control 2004 13:90-92 Health promotion
Drescher U, Warren F, Norton K. Towards evidence-based practice in medical training: making evaluations more meaningful. Med Educ 2004 12:1288-1294 Methodology
Figar S, Waisman G, De Quiros FG, Galarza C, Marchetti M, Loria GR, Camera L, Seinhart D, Camera M. Narrowing the gap in hypertension: effectiveness of a complex antihypertensive program in the elderly. Dis Manag 2004 7:235-243 Clinical
Glazener CM, Evans JH, Peto RE. Complex behavioural and educational interventions for nocturnal enuresis in children. Cochrane Database Syst Rev 2004 1:CD004668 Health promotion
Gülmezoglu AM, Villar J, Grimshaw J, Piaggio G, Lumbiganon P, Langer A. Cluster randomized trial of an active, multifaceted information dissemination intervention based on The WHO Reproductive health library to change obstetric practices: methods and design issues [ISRCTN14055385] BMC Med Res Methodol 2004 4:2 Other
Hammond A, Young A, Kidao R. A randomised controlled trial of occupational therapy for people with early rheumatoid arthritis. Ann Rheum Dis 2004 63:23-30 Clinical
Lawson H. The logic of collaboration in education and the human services. J Interprof Care 2004 18: 225-237 Other
Paterson C, Britten N. Acupuncture as a complex intervention: a holistic model. J Altern Complement Med 2004 10: 791-801 Clinical
Power R, Langhaug LF, Nyamurera T, Wilson D, Bassett MT, Cowan FM. Developing complex interventions for rigorous evaluation - a case study from rural Zimbabwe. Health Educ Res 2004 19:570-575 Methodology
Shemilt I, Harvey I, Shepstone L, Swift L, Reading R, Mugford M, Belderson P, Norris N, Thoburn J, Robinson J.A national evaluation of school breakfast clubs: evidence from a cluster randomized controlled trial and an observational analysis. Child Care Health Dev 2004 30: 413-427 Health promotion
Smith S, Bury, O’Leary M, Shannon W, Tynan A, Staines A, Thompson C. The North Dublin randomized controlled trial of structured diabetes shared care. Fam Pract 2004 21: 39-45 Clinical
Whitford DL, Roberts SH, Griffin S.Sustainability and effectiveness of comprehensive diabetes care to a district population. Diabet Med 2004 21: 1221-1228. Clinical
Bonetti D, Eccles M, Johnston M, Steen N, Grimshaw J, Baker R, Walker A, Pitts N. Guiding the design and selection of interventions to influence the implementation of evidence-based practice: an experimental simulation of a complex intervention trial. Soc Sci Med 2005 60:2135-2147 Methodology
Eldridge S, Spencer A, Cryer C, Parsons S, Underwood M, Feder G. Why modelling a complex intervention is an important precursor to trial design: lessons from studying an intervention to reduce falls-related injuries in older people. J Health Serv Res Policy 2005 10:133-142 Methodology
Greenhalgh T, Collard A, Begum N. Sharing stories: complex intervention for diabetes education in minority ethnic groups who do not speak English. BMJ 2005 330:628 Health promotion
Levesque L, .Guilbault G, Delormier T, Potvin L.Unpacking the black box: a deconstruction of the programming approach and physical activity interventions implemented in the Kahnawake Schools Diabetes Prevention Project. Health Promot Pract 2005 6:64-71 Health promotion
Nilsson S, Spak F, Marklund B, Baigi A, Allebeck P. Attitudes and behaviours with regards to androgenic anabolic steroids among male adolescents in a county of Sweden. Subst Use Misuse 2005 40:1-12 Other
Robinson L, Francis J, James P, Tindle N, Greenwell K, Rodgers H. Caring for carers of people with stroke: developing a complex intervention following the Medical Research Council framework. Clin Rehabil 2005 19:560-571 Health promotion
Rowlands G, Sims J, Kerry S. A lesson learnt: the importance of modelling in randomized controlled trials for complex interventions in primary care. Fam Pract 2005 22:132-139. Methodology
Blackwood B. Methodological issues in evaluating complex healthcare interventions. J Adv Nurs 2006 54:612-622 Methodology
Bower P, Gilbody S, Richards D, Fletcher J, Sutton A. Collaborative care for depression in primary care. Making sense of a complex intervention: systematic review and meta-regression. Br J Psychiatry 2006 189:484-493 Clinical
Byrne M, Cupples ME, Smith SM, Leathem C, Corrigan M, Byrne MC, Murphy AW. Development of a complex intervention for secondary prevention of coronary heart disease in primary care using the UK Medical Research Council framework. Am J Manag Care 2006 12:261-266 Clinical
Corrigan M, Cupples ME, Smith SM, Byrne M, Leathem CS, Clerkin P, Murphy AW. The contribution of qualitative research in designing a complex intervention for secondary prevention of coronary heart disease in two different healthcare systems. BMC Health Serv Res 2006 6:90 Methodology
Cullen W, Stanley J, Langton D, Kelly Y, Staines, A, Bury G. Hepatitis C infection among injecting drug users in general practice: a cluster randomised controlled trial of clinical guidelinesimplementation. Br J Gen Pract 2006 56:848-856 Clinical
Dornan T, Littlewood S, Margolis SA, Scherpbier A, Spencer J, Ypinazar V. How can experience in clinical and community settings contribute to early medical education? A BEME systematic review. Med Teach 2006 28:3-18 Health promotion
Greaves CJ, Farbus L. Effects of creative and social activity on the health and well-being of socially isolated older people: outcomes from a multi-method observational study. J R Soc Promot Health 2006 126:134-142 Public health
Heaven B, Murtagh M, Rapley T, May C, Graham R, Kaner E, Thomson R. Patients or research subjects? A qualitative study of participation in a randomised controlled trial of a complex intervention. Patient Educ Couns 2006 62:260-270 Methodology
Holbrook AM, Thabane L, Shcherbatykh IY, O'Reilly D. E-health interventions as complex interventions: improving the quality of methods of assessment. AMIA Annu Symp Proc 2006 AMIA 2006 Symposium Proceedings: 952 Methodology
Jansen YJ, Bal R, Bruijnzeels M, Foets M, Frenken R, de Bont A. Coping with methodological dilemmas; about establishing the effectiveness of interventions in routine medical practice. BMC Health Serv Res 2006 6:160 Methodology
Kasper J, Kopke S, Muhlhauser I, Heesen C.Evidence-based patient information about treatment of multiple sclerosis--a phase one study on comprehension and emotional responses. Patient Educ Couns 2006 62:56-63 Health promotion
Kunz R, Autti-Ramo I, Anttila H, Malmivaara A, Makela M. A systematic review finds that methodological quality is better than its reputation but can be improved in physiotherapy trials in childhood cerebral palsy. J Clin Epidemiol 2006 59:1239-1248 Methodology
MacPherson H, Thorpe L, Thomas K. Beyond needling - therapeutic processes in acupuncture care: a qualitative study nested within a low-back pain trial. J Altern Complement Med 2006 12:873-880 Clinical
Rapley T, May C, Heaven B, Murtagh M, Graham R, Kaner EF, Thomson R. Doctor-patient interaction in a randomised controlled trial of decision-support tools. Soc Sci Med 2006 62:2267-2278 Methodology
Salas I. Methodology for reorganization of the cervical cancer program in Chile. Cancer Detect Prev 2006 30:38-43 Public health
Sheik A, Baig K. An audit of the use and complications of glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention against national UK standards. Cardiovasc Revasc Med 2006 7:237-239 Clinical
Sisk JE, Hebert PL, Horowitz CR, McLaughlin MA, Wang JJ, Chassin MR. Effects of nurse management on the quality of heart failure care in minority communities: a randomized trial. Ann Intern Med 2006 145:273-283 Clinical
Sturt J, Hearnshaw H, Farmer A, Dale J, Eldridge S. The Diabetes Manual trial protocol - a cluster randomized controlled trial of a self-management intervention for type 2 diabetes [ISRCTN06315411]. BMC Fam Pract 2006 7:45 Health promotion
Sturt J, Taylor H, Docherty A, Dale J, Louise T.A psychological approach to providing self-management education for people with type 2 diabetes: the Diabetes Manual. BMC Fam Pract 2006 7:70 Health promotion
Sturt J, Whitlock S, Hearnshaw H. Complex intervention development for diabetes self-management. J Adv Nurs 2006 54:293-303 Health promotion
Treweek S, Sullivan F. How much does pre-trial testing influence complex intervention trials and would more testing make any difference? An email survey. BMC Med Res Methodol 2006 6:28 Methodology
Allegrante JP, Peterson MG, Cornell CN, MacKenzie CR, Robbins L, Horton R, Ganz SB, Ruchlin HS, Russo PW, Paget SA, Charlson ME. Methodological challenges of multiple-component intervention: lessons learned from a randomized controlled trial of functional recovery after hip fracture. HSS J 2007 3:63-70 Methodology
Armstrong N, Hearnshaw H, Powell J, Dale J.Stakeholder perspectives on the development of a virtual clinic for diabetes care: qualitative study. J Med Internet Res 2007 9:E23 Health promotion
Ciuffreda D, Pantaleo G, Pascual M. Effects of immunosuppressive drugs on HIV infection: implications for solid-organ transplantation. Transpl Int 2007 8:649-658 Clinical
Garfein RS, Swartzendruber A, Ouellet LJ, Kapadia F, Hudson SM, Thiede H, Strathdee SA, Williams IT, Bailey SL, Hagan H, Golub ET, Kerndt P, Hanson DL, Latka MH. Methods to recruit and retain a cohort of young-adult injection drug users for the Third Collaborative Injection Drug Users Study/Drug Users Intervention Trial (CIDUS III/DUIT).Drug Alcohol Depend 2007 91 Suppl 1:S4-17 Methodology
Green J, Jacobs B, Beecham J, Dunn G, Kroll L, Tobias C, Briskman J. Inpatient treatment in child and adolescent psychiatry - a prospective study of health gain and costs. J Child Psychol Psychiatry 2007 48:1259-1267 Clinical
Hoddinott P, Pill R, Chalmers M. Health professionals, implementation and outcomes: reflections on a complex intervention to improve breastfeeding rates in primary care. Fam Pract 2007 24:84-91 Health promotion
Lamb SE, Gates S, Underwood MR, Cooke MW, Ashby D, Szczepura A, Williams MA, Williamson EM, Withers EJ, Mt Isa S, Gumber A. Managing Injuries of the Neck Trial (MINT): design of a randomised controlled trial of treatments for whiplash associated disorders. BMC Musculoskelet Disord 2007 8:7 Clinical
MacPherson H, Schroer S. Acupuncture as a complex intervention for depression: a consensus method to develop a standardised treatment protocol for a randomised controlled trial. Complement Ther Med 2007 15:92-100 Clinical
May CR, Mair FS, Dowrick CF, Finch TL. Process evaluation for complex interventions in primary care: understanding trials using the normalization process model. BMC Fam Pract 2007 8:42 Methodology
Nardi R, Scanelli G, Corrao S, Iori I, Mathieu G, Cataldi Amatrian R. Co-morbidity does not reflect complexity in internal medicine patients. Eur J Intern Med 2007 18:359-368 Clinical
Paul G, Smith SM, Whitford D, O'Kelly F, O'Dowd T. Development of a complex intervention to test the effectiveness of peer support in type 2 diabetes. BMC Health Serv Res 2007 7:136 Health promotion
Paul GM, Smith SM, Whitford DL, O'Shea E, O'Kelly F, O'Dowd T. Peer support in type 2 diabetes: a randomised controlled trial in primary care with parallel economic and qualitative analyses: pilot study and protocol. BMC Fam Pract 2007 8:45 Health promotion
Peters-Klimm F, Muller-Tasch T, Schellberg D, Gensichen J, Muth C, Herzog W, Szecsenyi J.Rationale, design and conduct of a randomised controlled trial evaluating a primary care-based complex intervention to improve the quality of life of heart failure patients: HICMan (Heidelberg Integrated Case Management).BMC Cardiovasc Disord 2007 7:25 Clinical
Power R, Langhaug L, Cowan F. "But there are no snakes in the wood": risk mapping as an outcome measure in evaluating complex interventions. Sex Transm Infect 2007 83:232-236 Methodology
Protheroe J, Bower P, Chew-Graham C. The use of mixed methodology in evaluating complex interventions: identifying patient factors that moderate the effects of a decision aid. Fam Pract 2007 24:594-600 Methodology
Protopopoff N, Van Herp M, Maes P, Reid T, Baz D, D'Alessandro U, Van Bortel W, Coosemans M. Vector control in a malaria epidemic occurring within a complex emergency situation in Burundi: a case study. Malar J 2007 6:93 Public health
Qian X, Smith H, Huang W, Zhang J, Huang Y, Garner P. Promoting contraceptive use among unmarried female migrants in one factory in Shanghai: a pilot workplace intervention. BMC Health Serv Res 2007 7:77 Health promotion
Spillane V, Byrne MC, Byrne, M Leathem CS, O'Malley M, Cupples ME. Monitoring treatment fidelity in a randomized controlled trial of a complex intervention. J Adv Nurs 2007 60:343-352 Methodology
Turner DE, Helliwell PS, Woodburn J.Methodological considerations for a randomised controlled trial of podiatry care in rheumatoid arthritis: lessons from an exploratory trial. BMC Musculoskelet Disord 2007 8:109 Methodology
Wang HE, Abo BN, Lave JR, Yealy DM. How would minimum experience standards affect the distribution of out-of-hospital endotracheal intubations? Ann Emerg Med 2007 50:246-252 Clinical
Wiener-Ogilvie S, Pinnock H, Huby G, Sheikh A, Partridge MR, Gillies J. Do practices comply with key recommendations of the British Asthma Guideline? If not, why not? Prim Care Respir J 2007 16: 369-377 Clinical
Abelson JL, Khan S, Liberzon I, Erickson TM, Young EA. Effects of perceived control and cognitive coping on endocrine stress responses to pharmacological activation. Biol Psychiatry 2008 64:701-707 Clinical
Bosch-Capblanch X, Garner P. Primary health care supervision in developing countries. Trop Med Int Health 2008 13: 369-383 Other
Byng R, Norman I, Redfern S, Jones R. Exposing the key functions of a complex intervention for shared care in mental health: case study of a process evaluation. BMC Health Serv Res 2008 8:274 Methodology
Carrasco MP, Salvador CH, Sagredo PG, Marquez-Montes J, Gonzalez de Mingo MA, Fragua JA, Rodriguez MC, Garcia-Olmos LM, Garcia-Lopez F, Carrero AM, Monteagudo JL. Impact of patient-general practitioner short-messages-based interaction on the control of hypertension in a follow-up service for low-to-medium risk hypertensive patients: a randomized controlled trial. IEEE Trans Inf Technol Biomed 2008 12:780-791 Clinical
de Salis I, Tomlin Z, Toerien M, Donovan J. Using qualitative research methods to improve recruitment to randomized controlled trials: the Quartet study. J Health Serv Res Policy 2008 13 Suppl 3:92-96 Methodology
de Salis I, Tomlin Z, Toerien M, Donovan J. Qualitative research to improve RCT recruitment: issues arising in establishing research collaborations. Contemp Clin Trials 2008 29:663-670 Methodology
Eisenberg ML, Elliott SP, McAninch JW. Management of restenosis after urethral stent placement. J Urol 2008 179:991-5 Clinical
Fairall LR, Bachmann MO, Zwarenstein MF, Lombard CJ, Uebel K, van Vuuren C, Steyn D, Boulle A, Bateman ED. Streamlining tasks and roles to expand treatment and care for HIV: randomised controlled trial protocol. Trials 2008 9:21 Clinical
Fearon KC. Cancer cachexia: developing multimodal therapy for a multidimensional problem. Eur J Cancer 2008 44:1124-32 Clinical
Hawe P, Shiell A, Riley T. In response to Spillane V., Byrne M.C., Byrne M., Leathem C.S., O'Malley M. & Cupples M.E. (2007) Monitoring treatment fidelity in a randomized trial of a complex intervention. Journal of Advanced Nursing 60 (3) , 343-352. Important considerations for standardizing complex interventions. J Adv Nurs 2008 62:267 Methodology
Hendriks MR, Bleijlevens MH, van Haastregt JC, Bruijn FH, Diederiks JP, Mulder WJ, Ruijgrok JM, Stalenhoef PA, Crebolder HF,van Eijk JT. A multidisciplinary fall prevention program for elderly persons: a feasibility study. Geriatr Nurs 2008 29:186-196 Health promotion
Karamanidou C, Weinman J, Horne R. Improving haemodialysis patients' understanding of phosphate-binding medication: a pilot study of a psycho-educational intervention designed to change patients' perceptions of the problem and treatment. Br J Health Psychol 2008 13:205-214 Health promotion
Klinkhammer-Schalke M, Koller M, Ehret C, Steinger B, Ernst B, Wyatt JC, Hofstadter F, Lorenz W. Implementing a system of quality-of-life diagnosis and therapy for breast cancer patients: results of an exploratory trial as a prerequisite for a subsequent RCT. Br J Cancer 2008 99:415-422 Clinical
Klinkhammer-Schalke M, Koller M, Wyatt JC, Steinger B, Ehret C, Ernst B, Hofstadter F, Lorenz W. Quality of life diagnosis and therapy as complex intervention for improvement of health in breast cancer patients: delineating the conceptual, methodological, and logistic requirements (modelling). Langenbecks Arch Surg 2008 393:1-12 Methodology
MacPherson H, Nahin R, Paterson C, Cassidy CM, Lewith GT, Hammerschlag R. Developments in acupuncture research: big-picture perspectives from the leading edge. J Altern Complement Med 2008 14:883-887 Methodology
MacPherson H, Thomas K. Self-help advice as a process integral to traditional acupuncture care: implications for trial design. Complement Ther Med 2008 16:101-106 Health promotion
Narahari SR, Ryan TJ, Aggithaya MG, Bose KS, Prasanna KS. Evidence-based approaches for the Ayurvedic traditional herbal formulations: toward an Ayurvedic CONSORT model. J Altern Complement Med 2008 14:769-776 Methodology
Panella M, Marchisio S, Gardini A, Di Stanislao F. A cluster randomized controlled trial of a clinical pathway for hospital treatment of heart failure: study design and population. BMC Health Serv Res 2008 7:179 Clinical
Panella M, Brambilla R, Marchisio S, Di Stanislao F. Reducing stroke in-hospital mortality: organized care is a complex intervention. Stroke 2008 39:e186 Clinical
Patel VH, Kirkwood BR, Pednekar, S, Araya R, King M, Chisholm D, Simon G, Weiss H. Improving the outcomes of primary care attenders with common mental disorders in developing countries: a cluster randomized controlled trial of a collaborative stepped care intervention in Goa, India. Trials 2008 9:4 Clinical
Perkins D, Harris MF, Tan J, Christl B, Taggart J, Fanaian M. Engaging participants in a complex intervention trial in Australian General Practice. BMC Med Res Methodol 2008 8:55 Methodology
Sampson EL, Thune-Boyle I, Kukkastenvehmas R, Jones L, Tookman A, King M, Blanchard MR. Palliative care in advanced dementia; a mixed methods approach for the development of a complex intervention. BMC Palliat Care 2008 7:8 Clinical
Sifri ZC, Kim H, Lavery R, Mohr A, Livingston DH. The impact of obesity on the outcome of emergency intubation in trauma patients. J Trauma 2008 65:396-400 Clinical
Strong V, Waters R, Hibberd C, Murray G, Wall L, Walker J, McHugh G, Walker A, Sharpe M. Management of depression for people with cancer (SMaRT oncology 1) : a randomised trial. Lancet 2008 372:40-48 Clinical
Tee A, Calzavacca P, Licari E, Goldsmith D, Bellomo R. Bench-to-bedside review: the MET syndrome -the challenges of researching and adopting medical emergency teams. Crit Care 2008 12:205 Clinical
Vaessen J, Todd D. Methodological challenges of evaluating the impact of the Global Environment Facility's biodiversity program. Eval Program Plann 2008 31:231-240 Methodology
Wille N, Bettge S, Ravens-Sieberer U. Risk and protective factors for children's and adolescents' mental health: results of the BELLA study. Eur Child Adolesc Psychiatry 2008 17 Suppl 1:133-147 Health promotion
Wilson PM. The UK Expert Patients Program: lessons learned and implications for cancer survivors' self-care support programs. J Cancer Surviv 2008 2:45-52 Health promotion
Avery AJ, Rodgers S, Cantrill JA, Armstrong S, Elliott R, Howard R, Kendrick D, Morris CJ, Murray SA, Prescott RJ, Cresswell K, Sheikh A. Protocol for the PINCER trial: a cluster randomised trial comparing the effectiveness of a pharmacist-led IT-based intervention with simple feedback in reducing rates of clinically important errors in medicines management in general practices. Trials 2009 10:28 Health promotion
Blackberry ID, Furler JS, Young D, Best JD.What does it cost to establish a practice-nurses-led clinical trial in general practice? Med J Aust 2009 191: 492-495 Methodology
Bovend'Eerdt TJ, Botell RE, Wade DT. Writing SMART rehabilitation goals and achieving goal attainment scaling: a practical guide. Clin Rehabil 2009 23:352-361 Clinical
Cagle JG, Kovacs PJ. Education: a complex and empowering social work intervention at the end of life. Health Soc Work 2009 34:17-27 Health promotion
Colombet I, Sabatier B, Gillaizeau F, Prognon P, Begue , Durieux P. Long-term effects of a multifaceted intervention to encourage the choice of the oral route for proton pump inhibitors: an interrupted time-series analysis. Qual Saf Health Care 2009 18:232-235 Health promotion
Conboy L, Edshteyn I, Garivaltis H. Ayurveda and Panchakarma: measuring the effects of a holistic health intervention. ScientificWorldJournal 2009 9:272-280 Clinical
Connolly M, Grimshaw J, Dodd M, Cawthorne J, Hulme T, Everitt S, Tierney S, Deaton C. Systems and people under pressure: the discharge process in an acute hospital. J Clin Nurs 2009 18:4 Clinical
Donovan JL, Lane JA, Peters TJ, Brindle L, Salter E, Gillatt D, Powell P, Bollina P, Neal DE, Hamdy FC. Development of a complex intervention improved randomization and informed consent in a randomized controlled trial. J Clin Epidemiol 2009 62:29-36 Clinical
Dumont A, Fournier P, Fraser W, Haddad S, Traore M, Diop I, Gueye M, Gaye A, Couturier F, Pasquier, JC, Beaudoin F, Lalonde A, Hatem, M, Abrahamowicz, M. QUARITE (quality of care, risk management and technology in obstetrics): a cluster-randomized trial of a multifaceted intervention to improve emergency obstetric care in Senegal and Mali. Trials 2009 10:85 Clinical
Dyas JV, Apekey T, Tilling M, Siriwardena AN. Strategies for improving patient recruitment to focus groups in primary care: a case study reflective paper using an analytical framework. BMC Med Res Methodol 2009 9:65 Methodology
Farquhar MC, Higginson IJ, Fagan P, Booth S. The feasibility of a single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease. BMC Palliat Care 2009 8:9 Clinical
Holle R, Grassel E, Ruckdaschel S, Wunder S, Mehlig H, Marx P, Pirk O, Butzlaff M, Kunz S, Lauterberg J. Dementia care initiative in primary practice: study protocol of a cluster randomized trial on dementia management in a general practice setting. BMC Health Serv Res 2009 9:91 Clinical
King M, Jones L, McCarthy, O, Rogers M, Richardson A, Williams R, Tookman A, Nazareth I. Development and pilot evaluation of a complex intervention to improve experienced continuity of care in patients with cancer. Br J Cancer 2009 100:274-280 Clinical
Mao J, Hou Y, Shang H, Wang H, Wang X, Zhao Y, Niu T, Cui J, Li G, Lin Q, Shi L, Jia X, Fan R, Wang B, Ruan J. Study on the evaluation of the clinical effects of traditional chinese medicine in heart failure by complex intervention: protocol of SECETCM-HF. Trials 2009 10:122 Clinical
Mesotten D, Van den Berghe G. Clinical benefits of tight glycaemic control: focus on the intensive care unit. Best Pract Res Clin Anaesthesiol 2009 23:421-429 Clinical
Murphy AW, Cupples ME, Smith SM, Byrne M, Byrne MC, Newell J. Effect of tailored practice and patient care plans on secondary prevention of heart disease in general practice: cluster randomised controlled trial. 2009 BMJ 339:b4220 Clinical
Richards D A, Hughes-Morley A, Hayes RA, Araya R, Barkham M, Bland JM, Bower P, Cape J, Chew-Graham C A, Gask L, Gilbody S, Green C, Kessler D, Lewis G, Lovell K, Manning C, Pilling S. Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression - study protocol. BMC Health Serv Res 2009 9:188 Clinical
Rickles D. Causality in complex interventions. Med Health Care Philos 2009 12:77-90 Methodology
Schmidt-Kraepelin C, Janssen B, Gaebel W. Prevention of rehospitalization in schizophrenia: results of an integrated care project in Germany. Eur Arch Psychiatry Clin Neurosci 2009 259 Suppl 2:S205-12 Clinical
Schroer S, MacPherson H, Adamson J. Designing an RCT of acupuncture for depression--identifying appropriate patient groups: a qualitative study. Fam Pract 2009 26: 188-195 Clinical
Seers HE, Gale N, Paterson C, Cooke HJ, Tuffrey V, Polley MJ. Individualised and complex experiences of integrative cancer support care: combining qualitative and quantitative data. Support Care Cancer 2009 17:1159-1167 Clinical
Simon S, Higginson I J. Evaluation of hospital palliative care teams: strengths and weaknesses of the before-after study design and strategies to improve it. Palliat Med 2009 23:23-28 Clinical
Simpson SA, Butler CC, Hood K, Cohen D, Dunstan F, Evans MR, Rollnick S, Moore L, Hare M, Bekkers MJ, Evans J. Stemming the Tide of Antibiotic Resistance (STAR): a protocol for a trial of a complex intervention addressing the 'why' and 'how' of appropriate antibiotic prescribing in general practice. BMC Fam Pract 2009 10:20 Clinical
Siriwardena AN, Apekey T, Tilling M, Harrison A, Dyas JV, Middleton HC, Orner R, Sach T, Dewey M, Qureshi ZM. Effectiveness and cost-effectiveness of an educational intervention for practice teams to deliver problem focused therapy for insomnia: rationale and design of a pilot cluster randomised trial. BMC Fam Pract 2009 10:9 Health promotion
Suh JW, Kim SY, Park JS, Kim YS, Kang HJ, Koo BK, Kim HS. Comparison of triple antiplatelet therapy including triflusal and conventional dual therapy in patients who underwent drug-eluting stent implantation. Int Heart J 2009 50:701-709 Clinical
Thompson DR, Clark AM. Cardiac rehabilitation: into the future. Heart 2009 95:1897-1900 Clinical
Thompson EA, Relton C. Designing clinical trials of homeopathy for menopausal symptoms: a review of the literature. Menopause Int 2009 15:31-34 Clinical
Walker J, Cassidy J, Sharpe M. The second Symptom Management Research Trial in Oncology (SMaRT Oncology-2): a randomised trial to determine the effectiveness and cost-effectiveness of adding a complex intervention for major depressive disorder to usual care for cancer patients. Trials 2009 10:18 Clinical
Walker J, Cassidy J, Sharpe M. The third symptom management research trial in oncology (SMaRT oncology- 3) : a randomised trial to determine the efficacy of adding a complex intervention for major depressive disorder (depression care for people with lung cancer) to usual care, compared to usual care alone in patients with lung cancer. Trials 2009 10:92 Clinical
Ali M, Ashburn A, Bowen A, Brodie E, Corr S, Drummond A, Edmans J, Gladman, J, Kalra L, Langhorne P, Lees KR, Lincoln N, Logan P, Mead G, Patchick E, Pollock A, Pomeroy V, Sackley C, Sunnerhagen K S, van Vliet P, Walker M, Brady M. VISTA-Rehab: a resource for stroke rehabilitation trials. Int J Stroke 2010 5:447-52 Methodology
Amặlinei C, Caruntu ID, Giusca, SE, Balan, RA. Matrix metalloproteinases involvement in pathologic conditions. Rom J Morphol Embryol 2010 51:215-28 Clinical
Cameron ID. Models of rehabilitation - commonalities of interventions that work and of those that do not. Disabil Rehabil 2010 32:1051-1058 Methodology
Cousins K, Connor JL, Kypri K. Reducing alcohol-related harm and social disorder in a university community: a framework for evaluation. Inj Prev 2010 16:e1-6 Health promotion
Craig LE, Bernhardt J, Langhorne P, Wu O. Early mobilization after stroke: an example of an individual patient data meta-analysis of a complex intervention. Stroke 2010 41:2632-2636 Clinical
de Vlaming R, Haveman-Nies A, Van't Veer P, de Groot LC. Evaluation design for a complex intervention program targeting loneliness in non-institutionalized elderly Dutch people. BMC Public Health 2010 10:552 Public health
Dorresteijn JA, Kriegsman DM, Valk GD. Complex interventions for preventing diabetic foot ulceration. Cochrane Database Syst Rev 2010 CD007610 Clinical
Emsley R, Dunn G, White IR. Mediation and moderation of treatment effects in randomised controlled trials of complex interventions. Stat Methods Med Res 2010 19:237-70 Methodology
Farquhar M, Higginson IJ, Fagan P, Booth S. Results of a pilot investigation into a complex intervention for breathlessness in advanced chronic obstructive pulmonary disease (COPD): brief report. Palliat Support Care 2010 8:143-149 Clinical
Hill GM, Sowden JM, Lister RK, Logan, RA, Finlay AY. Dermatology outpatient case-mix survey for all Welsh Trusts, 2007. Br J Dermatol 2010 162:152-158 Clinical
Hoddinott P, Britten J, Pill R. Why do interventions work in some places and not others: a breastfeeding support group trial. Soc Sci Med 2010 70:769-778 Health promotion
Horsburgh M, Goodyear-Smith F, Bycroft J, Mahony, F, Roy D, Miller D, Donnell E. Lessons learnt from attempting to assess the evidence base for a complex intervention introduced into New Zealand general practice. Qual Saf Health Care 2010 19:e50 Methodology
Hunter B, Segrot J. Using a clinical pathway to support normal birth: impact on practitioner roles and working practices. Birth 2010 37:227-236 Clinical
Hutchinson C, Lange I, Kanhonou L, Filippi V, Borchert M. Exploring the sustainability of obstetric near-miss case reviews: a qualitative study in the South of Benin. Midwifery 2010 26:537-543 Methodology
Jiwa M, Mitchell G, Sibbrit D, Girgis A, Burridge L. Addressing the needs of caregivers of cancer patients in general practice: a complex intervention. Qual Prim Care 2010 18:9-16 Health promotion
Kirkegaard P, Edwards G, Hansen B, Hansen MD, Jensen MS, Lauritzen T, Risoer MB, Thomsen JL. The RISAP-study: a complex intervention in risk communication and shared decision-making in general practice. BMC Fam Pract 2010 11:70 Health promotion
Korb-Savoldelli V, Sabatier B, Gillaizeau F, Guillemain R, Prognon P, Begue D, Durieux P. Non-adherence with drug treatment after heart or lung transplantation in adults: a systematic review. Patient Educ Couns 2010 81:148-154 Clinical
Langhorne P, Lewsey JD, Jhund PS, Gillies M, Chalmers JW, Redpath A, Briggs A, Walters M, Capewell S, McMurray JJ, MacIntyre K. Estimating the impact of stroke unit care in a whole population: an epidemiological study using routine data. J Neurol Neurosurg Psychiatry 2010 81:1301-1305 Clinical
Mayer S, Weisser M, Till H, Grafe G, Geyer C. Congenital myelomeningocele - do we have to change our management? Cerebrospinal Fluid Res 2010 7:17 Clinical
McKibbon KA, Lokker, C, Wilczynski NL, Ciliska D, Dobbins M, Davis DA, Haynes RB, Straus SE. A cross-sectional study of the number and frequency of terms used to refer to knowledge translation in a body of health literature in 2006: a Tower of Babel? Implement Sci 2010 5:16 Methodology
Murray, E. Treweek, S. Pope, C. MacFarlane, A. Ballini, L. Dowrick, C. Finch, T. Kennedy, A. Mair, F. O'Donnell, C. Ong, B. N. Rapley, T. Rogers, A. May, C. Normalisation process theory: a framework for developing, evaluating and implementing complex interventions. BMC Med 2010 8:63 Methodology
O'Carroll, R. Dennis, M. Johnston, M. Sudlow, C. Improving adherence to medication in stroke survivors (IAMSS): a randomised controlled trial: study protocol. BMC Neurol 2010 10:15 Clinical
Reavley N, Livingston J, Buchbinder R, Bennell K, Stecki C, Osborne RH. A systematic grounded approach to the development of complex interventions: the Australian Work Health Program--arthritis as a case study. Soc Sci Med 2010 70:342-350 Health promotion
Sankaran S, Kenealy T, Adair A, Adair V, Coster H, Whitehead N, Sheridan N, Parsons M, Marshall E, Bailey L, Price C, Crombie D, Rea H. A complex intervention to support 'rest home' care: a pilot study. N Z Med J 2010 123:41-53 Health promotion
Siddiqi K, Khan A, Ahmad M, Shafiq-ur-Rehman. An intervention to stop smoking among patients suspected of TB - evaluation of an integrated approach. BMC Public Health 2010 10:160 Health promotion
Sollid SJ, Lossius HM, Nakstad AR, Aven T, Soreide E. Risk assessment of pre-hospital trauma airway management by anaesthesiologists using the predictive Bayesian approach. Scand J Trauma Resusc Emerg Med 2010 18:22 Clinical
Song J, Ratner ER, Wall MM, Bartels DM, Ulvestad N, Petroskas D, West M, Weber-Main AM, Grengs L, Gelberg L. Effect of an end-of-life planning intervention on the completion of advance directives in homeless persons: a randomized trial. Ann Intern Med 2010 153:76-84 Health promotion
Thompson A, Sullivan S, Barley M, Moore L, Rogers P, Sipos A, Harrison G. Effectiveness of a cognitive behavioural workbook for changing beliefs about antipsychotic polypharmacy: analysis from a cluster randomized controlled trial. J Eval Clin Pract 2010 16:520-528 Health promotion
Thompson EA. Alternative and complementary therapies for the menopause: a homeopathic approach. Maturitas 2010 66:350-354 Clinical
Van Herck P, Vanhaecht K, Deneckere S, Bellemans J, Panella M, Barbieri A, Sermeus W. Key interventions and outcomes in joint arthroplasty clinical pathways: a systematic review. J Eval Clin Pract 2010 16:39-49 Clinical
Vanhaecht K, Sermeus W, Peers J, Lodewijckx C, Deneckere S, Leigheb F, Decramer M, Panella M. The impact of care pathways for exacerbation of Chronic Obstructive Pulmonary Disease: rationale and design of a cluster randomized controlled trial. Trials 2010 11:111 Clinical
Walker J, Fairley CK, Walker SM, Gurrin L C, Gunn JM, Pirotta MV, Carter R, Hocking JS. Computer reminders for Chlamydia screening in general practice: a randomized controlled trial. Sex Transm Dis 2010 37:445-450 Health promotion
Barasa EW, English M. Economic evaluation of package of care interventions employing clinical guidelines. Trop Med Int Health 2011 16:97-104 Methodology
Barker M, Baird J, Lawrence W, Jarman M, Black C, Barnard K, Cradock S, Davies J, Margetts B Inskip H, Cooper C. The Southampton Initiative for Health: a complex intervention to improve the diets and increase the physical activity levels of women from disadvantaged communities. J Health Psychol 2011 16:178-191 Health promotion
Begh RA, Aveyard P, Upton P, Bhopal RS, White M, Amos A, Prescott RJ, Bedi R, Barton PM, Fletcher M, Gill P, Zaidi Q, Sheikh A. Experiences of outreach workers in promoting smoking cessation to Bangladeshi and Pakistani men: longitudinal qualitative evaluation. BMC Public Health 2011 11:452 Health promotion
Bennell KL, Egerton T, Pua YH, Abbott JH, Sims K, Buchbinder R. Building the rationale and structure for a complex physical therapy intervention within the context of a clinical trial: a multimodal individualized treatment for patients with hip osteoarthritis. Phys Ther 2011 91:1525-1541 Clinical
Bird L, Arthur A, Cox K. "Did the trial kill the intervention?" experiences from the development, implementation and evaluation of a complex intervention. BMC Med Res Methodol 2011 11:24 Clinical
Boase S, Kim Y, Craven A, Cohn S. Involving practice nurses in primary care research: the experience of multiple and competing demands. J Adv Nurs 2011 68:590-599 Methodology
Borglin G, Gustafsson M, Krona H. A theory-based educational intervention targeting nurses' attitudes and knowledge concerning cancer-related pain management: a study protocol of a quasi-experimental design. BMC Health Serv Res 2011 11:233 Clinical
Brady MC, Stott DJ, Norrie J, Chalmers C, St George B, Sweeney PM, Langhorne P. Developing and evaluating the implementation of a complex intervention: using mixed methods to inform the design of a randomised controlled trial of an oral healthcare intervention after stroke. Trial 2011 12:168 Clinical
Braun SM, Wade DT, Beurskens AJ. Use of movement imagery in neurorehabilitation: researching effects of a complex intervention. Int J Rehabil Res 2011 34:203-208 Clinical
Burr JM, Campbell MK, Campbell SE, Francis JJ, Greene A, Hernandez R, Hopkins D, McCann SK, Vale LD. Developing the clinical components of a complex intervention for a glaucoma screening trial: a mixed methods study. BMC Med Res Methodol 2011 11:54 Clinical
Carter G, Britton B, Clover K, Rogers K, Adams C, McElduff P. Effectiveness of QUICATOUCH: a computerised touch screen evaluation for pain and distress in ambulatory oncology patients in Newcastle, Australia. Psycho-Oncology 2011 DOI:10.1002/pon.2020 Clinical
Charles JM, Bywater T, Edwards RT. Parenting interventions: a systematic review of the economic evidence. Child Care Health Dev 2011 37:462-474 Health promotion
Christie D, Hudson L, Mathiot A, Cole TJ, Karlsen S, Kessel A, Kinra S, Morris S, Nazareth I, Sovio U, Wong IC, Viner RM. Assessing the efficacy of the healthy eating and lifestyle programme (HELP) compared with enhanced standard care of the obese adolescent in the community: study protocol for a randomized controlled trial. Trials 2011 12:242 Health promotion
Costantini M, Ottonelli S, Canavacci L, Pellegrini F, Beccaro M. The effectiveness of the Liverpool care pathway in improving end of life care for dying cancer patients in hospital. A cluster randomised trial. BMC Health Serv Res 2011 11:13 Clinical
Dowding DW, Cheyne HL, Hundley V. Complex interventions in midwifery care: reflections on the design and evaluation of an algorithm for the diagnosis of labour. Midwifery 2011 27:654-659 Methodology
Dunn G, Fowler D, Rollinson R, Freeman D, Kuipers E, Smith B, Steel C, Onwumere J, Jolley S, Garety P, Bebbington P. Effective elements of cognitive behaviour therapy for psychosis: results of a novel type of subgroup analysis based on principal stratification. Psychol Med 2011 DOI: 10.1017/S0033291711001954 Clinical
Edwards ED, Mason BW, Oliver A, Powell CV. Cohort study to test the predictability of the Melbourne criteria for activation of the medical emergency team. Arch Dis Child 2011 96:174-179 Clinical
Farquhar MC, Ewing G, Booth S. Using mixed methods to develop and evaluate complex interventions in palliative care research. Palliat Med 2011 25:748-757 Methodology
Farquhar MC, Prevost AT, McCrone P, Higginson IJ, Gray J, Brafman-Kennedy B, Booth S. Study protocol: Phase III single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease. Trials 2011 12:130 Clinical
Forster DA, Newton M, McLachlan HL, Willis K. Exploring implementation and sustainability of models of care: can theory help? BMC Public Health 2011 11 (Suppl 5): S8 Methodology
Gask L, Dowrick C, Salmon P, Peters S, Morriss R. Reattribution reconsidered: narrative review and reflections on an educational intervention for medically unexplained symptoms in primary care settings. J Psychosom Res 2011 71:325-334 Methodology
Greenhalgh T, Campbell-Richards D, Vijayaraghavan S, Collard A, Malik F, Griffin M, Morris J, Claydon A, Macfarlane F. New models of self-management education for minority ethnic groups: pilot randomized trial of a story-sharing intervention. J Health Serv Res Policy 2011 16:28-36 Health promotion
Gustafsson L, Nugent N, Biros L. Occupational therapy practice in hospital-based stroke rehabilitation? Scand J Occup Ther 2011 DOI: 10.3109/11038128 Clinical
Haire BG. Because we can: clashes of perspective over researcher obligation in the failed PrEP trials. Dev World Bioeth 2011 11:63-74 Methodology
Hansen DG, Bergholdt SH, Holm L, Kragstrup J, Bladt T,Sondergaard J. A complex intervention to enhance the involvement of general practitioners in cancer rehabilitation. Protocol for a randomised controlled trial and feasibility study of a multimodal intervention. Acta Oncol 2011 50:299-306 Clinical
Hirsch O, Keller H, Krones T, Donner-Banzhoff N. Acceptance of shared decision making with reference to an electronic library of decision aids (arriba-lib) and its association to decision making in patients: an evaluation study. Implement Sci 2011 6:70 Health promotion
James DM. The applicability of normalisation process theory to speech and language therapy: a review of qualitative research on a speech and language intervention. Implement Sci 2011 6:95 Methodology
Kearns A, Whitley E, Mason P, Petticrew M, Hoy C. Material and meaningful homes: mental health impacts and psychosocial benefits of rehousing to new dwellings. Int J Public Health 2011 56:597-607 Public health
Kirkevold M, Bronken BA, Martinsen R, Kvigne K. Promoting psychosocial well-being following a stroke: Developing a theoretically and empirically sound complex intervention. Int J Nurs Stud 2011 DOI: 10.1016/j.ijnurstu Health promotion
Lee MS, Choi TY,Kim JI, Kim L, Ernst E. Acupuncture for treating attention deficit hyperactivity disorder: a systematic review and meta-analysis. Chin J Integr Med 2011 17:257-260 Clinical
Lossius HM, Sollid SJ, Rehn M, Lockey DJ. Revisiting the value of pre-hospital tracheal intubation: an all time systematic literature review extracting the Utstein airway core variables. Crit Care 2011 15:R26 Clinical
Maratos A, Crawford MJ, Procter S. Music therapy for depression: it seems to work, but how? Br J Psychiatry 2011 199:92-93 Clinical
Mayo NE, Scott S. Evaluating a complex intervention with a single outcome may not be a good idea: an example from a randomised trial of stroke case management. Age Ageing 2011 40:718-724 Clinical
McLean S, Nurmatov U, Liu JL, Pagliari C, Car J,Sheikh A. Telehealthcare for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2011 DOI: 10.1002/14651858.CD007718.pub2. Clinical
McQuay H. Evidence-based medicine: what is the evidence that it has made a difference? Palliat Med 2011 25:394-397 Methodology
Melis RJ, Teerenstra S,Olde Rikkert MG, Borm GF. Pseudo cluster randomization: balancing the disadvantages of cluster and individual randomization. Eval Health Prof 2011 34:151-163 Methodology
Milanese S. The use of RCT's in manual therapy-- are we trying to fit a round peg into a square hole? Man Ther 2011 16:403-405 Methodology
Morrison JJ, Mellor A, Midwinter M, Mahoney PF, Clasper JC. Is pre-hospital thoracotomy necessary in the military environment? Injury 2011 42:469-473 Clinical
Ogilvie D, Bull F, Powell J, Cooper AR, Brand C, Mutrie N, Preston J, Rutter H. An applied ecological framework for evaluating infrastructure to promote walking and cycling: the iConnect study. Am J Public Health 2011 101:473-481 Public health
Price S, Long AF, Godfrey M, Thomas KJ. Getting inside acupuncture trials--exploring intervention theory and rationale. BMC Complement Altern Med 2011 11:22 Methodology
Sampson EL, Jones L, Thune-Boyle IC, Kukkastenvehmas R, King M, Leurent B, Tookman A, Blanchard MR. Palliative assessment and advance care planning in severe dementia: an exploratory randomized controlled trial of a complex intervention. Palliat Med 2011 25:197-209 Clinical
Schiapparelli P, Allais G, Rolando S, Airola G, Borgogno P, Terzi MG, Benedetto C. Acupuncture in primary headache treatment. Neurol Sci 2011 32 Suppl 1:S15-8 Clinical
Schroer S, Adamson J. Acupuncture for depression: a critique of the evidence base. CNS Neurosci Ther 2011 17: 398-410 Methodology
Senn B, Kirsch M, Sanz CC, Karlou C, Tulus K, De Leeuw J, Ringner A, Goossens GA, Cleary V. How cancer research could benefit from the Complex Intervention Framework: students' experiences of the European Academy of Nursing Science summer school. Eur J Cancer Care (Engl) 2011 20:1-4 Methodology
Siddiqi N, Young J, House AO, Featherstone I, Hopton A, Martin C, Edwards J, Krishnan R, Peacock R, Holt R. Stop Delirium! A complex intervention to prevent delirium in care homes: a mixed-methods feasibility study. Age Ageing 2011 40:90-98 Clinical
Wallcraft J. The person in health care policy development. J Eval Clin Pract 2011 17:347-349 Public health
Young K, Bunn F, Trivedi D, Dickinson A. Nutritional education for community dwelling older people: a systematic review of randomised controlled trials. Int J Nurs Stud 2011 48:751-780 Health promotion