Effects of lifestyle education program for type 2 diabetes patients in clinics: a cluster randomized controlled trial

Adachi, Misa; Yamaoka, Kazue; Watanabe, Mariko; Nishikawa, Masako; Kobayashi, Itsuro; Hida, Eisuke; Tango, Toshiro

doi:10.1186/1471-2458-13-467

Table 3 Mean change at 6th months from baseline in clinical data

From: Effects of lifestyle education program for type 2 diabetes patients in clinics: a cluster randomized controlled trial

	Intervention			Control			Model 1 (crude)			Model 2 (adjusted)			Model 3 (adjusted)			Model 4 (adjusted)
	Mean	±	SE	Mean	±	SE	Difference	95%CI	p-value	Difference	95%CI	p-value	Differences	95%CI	p-value	Difference	95%CI	p-value
HbA_1c(%)^#
LOCF¹⁾	−0.7	±	0.1	−0.2	±	0.1	−0.5	(−0.8 to −0.2)	0.004	−0.5	(−0.8 to −0.2)	0.004	−0.5	(−0.8 to −0.2)	0.003	−0.5	(−0.9 to −0.1)	0.011
CDS²⁾	−0.7	±	0.1	−0.2	±	0.1	−0.5	(−0.9 to −0.1)	0.009	−0.4	(−0.8 to −0.1)	0.014	−0.5	(−0.1 to −0.8)	0.013	−0.5	(−1.0 to −0.1)	0.028
MI³⁾	−0.7	±	0.1	−0.3	±	0.1	−0.5	(−0.9 to −0.1)	0.030	−0.4	(−0.8 to −0.1)	0.041	−0.4	(−0.8 to −0.2)	0.045	−0.4	(−0.6to −0.0)	0.045
BMI(kg/m²)
LOCF¹⁾	−0.5	±	0.1	−0.3	±	0.2	−0.2	(−0.7 to 0.2)	0.351	−0.1	(−0.6 to 0.4)	0.598	−0.1	(−0.6 to 0.3)	0.548	−0.3	(−0.8 to 0.2)	0.221
CDS²⁾	−0.6	±	0.2	−0.3	±	0.2	−0.3	(−0.8 to 0.1)	0.146	−0.2	(−0.8 to 0.3)	0.331	−0.3	(−0.8 to 0.3)	0.297	−0.3	(−0.9 to 0.2)	0.216
MI³⁾	−0.5	±	0.1	−0.3	±	0.2	−0.2	(−0.7 to 0.2)	0.351	−0.1	(−0.7 to 0.5)	0.693	−0.1	(−0.7 to 0.4)	0.633	−0.1	(−0.6 to 0.5)	0.829
FPG(mg/dl)
LOCF¹⁾	−19	±	8	−20	±	8	1	(−23 to 25)	0.919	8	(−11 to 28)	0.367	9	(−11 to 29)	0.347	22	(−10 to 54)	0.165
CDS²⁾	−20	±10	10	−14	±	11	7	(−37 to 23)	0.633	1	(−23 to 25)	0.933	0	(−25 to 25)	0.993	5	(−33 to 43)	0.792
MI^{3) $}
SBP(mmHg)
LOCF¹⁾	−1	±	3	0	±	3	1	(−9 to 7)	0.748	−1	(−7 to 6)	0.802	0	(−7 to 6)	0.963	0	(−8 to 8)	0.951
CDS²⁾	−1	±	3	−2	±	3	1	(−7 to 9)	0.804	2	(−5 to 9)	0.514	4	(−4 to 9)	0.416	4	(−5 to 12)	0.370
MI³⁾	−1	±	3	−2	±	3	−1	(−9 to 7)	0.738	−2	(−8 to 5)	0.593	−2	(−9 to 5)	0.523	−3	(−11 to 4)	0.368
DBP(mmHg)
LOCF¹⁾	−1	±	1	−3	±	2	1	(−3 to 6)	0.560	−3	(−1 to 7)	0.164	−2	(−2 to 6)	0.239	4	(−1 to 8)	0.088
CDS²⁾	−0	±	1	−4	±	1	3	(−1 to 7)	0.159	4	(−0 to 8)	0.050	4	(−0 to 8)	0.073	5	(0 to 10)	0.049
MI³⁾	−1	±	1	−3	±	2	−2	(−7 to 2)	0.296	−3	(−8 to 1)	0.120	−3	(−8 to 1)	0.166	−3	(−8 to 2)	0.171
LDL(mg/dl)
LOCF¹⁾	−5	±	2	−1	±	2	−4	(−10 to 3)	0.286	−2	( −8 to 3)	0.387	−3	(−10 to 3)	0.245	−4	(−13 to 5)	0.344
CDS²⁾	−4	±	2	0	±	3	−4	(−12 to 3)	0.241	−3	(−10 to 4)	0.371	−4	(−11 to 3)	0.252	−5	(−16 to 5)	0.283
MI³⁾	−5	±	4	2	±	4	7	( 2 to 12)	0.198	6	( 0 to 10)	0.250	7	(−4 to 17)	0.196	7	(−6 to 18)	0.223
HDL(mg/dl)
LOCF¹⁾	−1	±	1	1	±	1	−0	(−4 to 3)	0.823	−0	(−4 to 3)	0.863	0	(−3 to 4)	0.861	2	(−3 to 8)	0.393
CDS²⁾	1	±	2	2	±	2	−1	(−6 to 4)	0.745	−1	(−6 to 4)	0.701	0	(−5 to 5)	0.994	2	(−3 to 8)	0.393
MI^{3) $}
Triglycerides(mg/dl)
LOCF¹⁾	−3	±	8	−5	±	9	2	(−23 to 26)	0.894	4	(−20 to 28)	0.748	2	(−22 to 27)	0.239	7	(−28 to 43)	0.667
CDS²⁾	−7	±	8	−5	±	9	−3	(−29 to 24)	0.833	4	(−27 to 25)	0.951	−5	(−31 to 22)	0.708	−1	(−38 to 36)	0.953
MI^{3) $}

SE: standard error, 95%CI: 95% confidence interval, degree of freedom = 18.
^# Value of HbA_1C is JDS¹⁵.
1) LOCF: last observation carried forward (IG: n = 100, CG: n = 93).
2) CDS: complete data set. (IG: n = 84), CG: n = 70).
3) MI: Multiple imputation with all analysed variables (number of imputations = 200) (IG: n = 100, CG: n = 93).
Model 1: crude.
Model 2: mixed model adjusted for baseline.
Model 3: mixed model adjusted for baseline, gender, age and BMI.
Model 4: mixed model adjusted for baseline, gender, age, BMI, smoking status, exercise status, change of exercise level, family history of type 2 diabetes, and complication.
^$ The MI models did not converge.

Back to article page

ISSN: 1471-2458

Contact us

Submission enquiries: bmcpublichealth@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Public Health

Contact us