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Table 4 Odds ratio of cardiovascular risk or its components according to tertiles of uric acid in university workers of State of Mexico, 2004

From: Association between serum uric acid levels and cardiovascular risk among university workers from the State of Mexico: a nested case–control study

Dependent variables

Uric acid levels c

Crude odds ratio (95% CI)

Multivariate-adjusted aodds ratio (95% CI)

Multivariate-adjusted bodds ratio (95% CI)

High cardiovascular risk

Tertile 3

1.41 (1.01, 1.98)

1.48 (1.04, 2.10)

1.28 (0.89, 1.83)

(10-year CR ≥10.0%)

Tertile 2

1.22 (0.87, 1.72)

1.28 (0.90, 1.81)

1.19 (0.83, 1.69)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.060

0.031

0.122

Cardiovascular risk factors:

    

Age, y (≥ 40 men, ≥ 45 women)

    
 

Tertile 3

1.27 (0.87, 1.85)

1.28 (0.87, 1.87)

1.15 (0.78, 1.71)

 

Tertile 2

1.51 (1.04, 2.18)

1.53 (1.04, 2.24)

1.47 (1.00, 2.17)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.960

0.805

0.737

Hypertension

Tertile 3

1.93 (1.32, 2.82)

1.86 (1.26, 2.74)

1.65 (1.11, 2.45)

 

Tertile 2

1.48 (1.01, 2.17)

1.43 (0.96, 2.12)

1.36 (0.91, 2.04)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.001

0.001

0.002

Elevated cholesterol

Tertile 3

1.81 (1.23, 2.65)

1.83 (1.24, 2.71)

1.80 (1.21, 2.68)

Level

Tertile 2

1.17 (0.80, 1.71)

1.19 (0.81, 1.74)

1.18 (0.80, 1.73)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.001

0.001

0.003

Low HDL-chol level

Tertile 3

1.66 (1.04, 2.64)

1.67 (1.04, 2.69)

1.40 (0.85, 2.29)

 

Tertile 2

1.27 (0.81, 2.00

1.28 (0.81, 2.02)

1.16 (0.73, 1.85)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.002

0.002

0.025

Type 2 diabetes

Tertile 3

1.14 (0.69, 1.88)

1.29 (0.76, 2.18)

1.20 (0.70, 1.97)

 

Tertile 2

0.86 (0.52, 1.43)

0.96 (0.57, 1.63)

0.92 (0.54, 1.56)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.575

0.273

0.566

Smoking

Tertile 3

1.25 (0.75, 2.10)

1.21(0.71, 2.06)

1.17 (0.67, 2.02)

 

Tertile 2

0.95 (0.57, 1.56)

1.01 (0.60, 1.70)

0.99 (0.58, 1.68)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.820

0.971

0.951

≥3 cardiovascular risk

Tertile 3

1.88 (1.30, 2.72)

1.88 (1.29, 2.74)

1.65 (1.12, 2.43)

Factors

Tertile 2

1.39 (0.97, 1.99)

1.41 (0.97, 2.04)

1.33 (0.91, 1.93)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.001

0.001

0.008

Body mass index ≥25

Tertile 3

2.89 (1.86, 4.50)

2.86 (1.82, 4.50)

2.86 (1.82, 4.50)

kg/m2 (overweight-obesity)

Tertile 2

1.66 (1.08, 2.56)

1.68 (1.08, 2.60)

1.68 (1.08, 2.60)

 

Tertile 1

1

1

1

 

Trend over tertiles, p

0.001

0.001

0.001

  1. a Adjusted for physical activity (inactivity, insufficient activity, recommended activity) alcoholic beverages consumption per day (0, <2, >2), and family history of myocardial infarction.
  2. b Adjusted for body mass index (< 25 kg/m2, ≥ 25 kg/m2), in addition to the variables included in “a”.
  3. c Tertile 3: ≥ 5.35 mg/dL; tertile 2: 4.19 - 5.34 mg/dL; tertile 1: ≤ 4.18 mg/dL.
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