TY - JOUR AU - Abellan Van Kan, G. AU - Rolland, Y. AU - Andrieu, S. AU - Bauer, J. AU - Beauchet, O. AU - Bonnefoy, M. AU - Cesari, M. AU - Donini, L. M. AU - Gillette Guyonnet, S. AU - Inzitari, M. PY - 2009 DA - 2009// TI - Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force JO - J Nutr Health Aging VL - 13 UR - https://doi.org/10.1007/s12603-009-0246-z DO - 10.1007/s12603-009-0246-z ID - Abellan Van Kan2009 ER - TY - JOUR AU - Studenski, S. AU - Perera, S. AU - Patel, K. AU - Rosano, C. AU - Faulkner, K. AU - Inzitari, M. AU - Brach, J. AU - Chandler, J. AU - Cawthon, P. AU - Connor, E. B. PY - 2011 DA - 2011// TI - Gait speed and survival in older adults JO - JAMA VL - 305 UR - https://doi.org/10.1001/jama.2010.1923 DO - 10.1001/jama.2010.1923 ID - Studenski2011 ER - TY - JOUR AU - Cooper, R. AU - Kuh, D. AU - Cooper, C. AU - Gale, C. R. AU - Lawlor, D. A. AU - Matthews, F. AU - Hardy, R. PY - 2011 DA - 2011// TI - Objective measures of physical capability and subsequent health: a systematic review JO - Age Ageing VL - 40 UR - https://doi.org/10.1093/ageing/afq117 DO - 10.1093/ageing/afq117 ID - Cooper2011 ER - TY - JOUR AU - Verghese, J. AU - Holtzer, R. AU - Lipton, R. B. AU - Wang, C. PY - 2009 DA - 2009// TI - Quantitative gait markers and incident fall risk in older adults JO - J Gerontol A Biol Sci Med Sci VL - 64 UR - https://doi.org/10.1093/gerona/glp033 DO - 10.1093/gerona/glp033 ID - Verghese2009 ER - TY - JOUR AU - Cesari, M. AU - Kritchevsky, S. B. AU - Newman, A. B. AU - Simonsick, E. M. AU - Harris, T. B. AU - Penninx, B. W. AU - Brach, J. S. AU - Tylavsky, F. A. AU - Satterfield, S. AU - Bauer, D. C. PY - 2009 DA - 2009// TI - Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging And Body Composition Study JO - J Am Geriatr Soc VL - 57 UR - https://doi.org/10.1111/j.1532-5415.2008.02126.x DO - 10.1111/j.1532-5415.2008.02126.x ID - Cesari2009 ER - TY - JOUR AU - Montero-Odasso, M. AU - Schapira, M. AU - Soriano, E. R. AU - Varela, M. AU - Kaplan, R. AU - Camera, L. A. AU - Mayorga, L. M. PY - 2005 DA - 2005// TI - Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older JO - J Gerontol A Biol Sci Med Sci VL - 60 UR - https://doi.org/10.1093/gerona/60.10.1304 DO - 10.1093/gerona/60.10.1304 ID - Montero-Odasso2005 ER - TY - JOUR AU - Cesari, M. AU - Kritchevsky, S. B. AU - Penninx, B. W. AU - Nicklas, B. J. AU - Simonsick, E. M. AU - Newman, A. B. AU - Tylavsky, F. A. AU - Brach, J. S. AU - Satterfield, S. AU - Bauer, D. C. PY - 2005 DA - 2005// TI - Prognostic value of usual gait speed in well-functioning older people–results from the Health, Aging and Body Composition Study JO - J Am Geriatr Soc VL - 53 UR - https://doi.org/10.1111/j.1532-5415.2005.53501.x DO - 10.1111/j.1532-5415.2005.53501.x ID - Cesari2005 ER - TY - JOUR AU - Inzitari, M. AU - Newman, A. B. AU - Yaffe, K. AU - Boudreau, R. AU - de Rekeneire, N. AU - Shorr, R. AU - Harris, T. B. AU - Rosano, C. PY - 2007 DA - 2007// TI - Gait speed predicts decline in attention and psychomotor speed in older adults: the health aging and body composition study JO - Neuroepidemiology VL - 29 UR - https://doi.org/10.1159/000111577 DO - 10.1159/000111577 ID - Inzitari2007 ER - TY - JOUR AU - Watson, N. L. AU - Rosano, C. AU - Boudreau, R. M. AU - Simonsick, E. M. AU - Ferrucci, L. AU - Sutton-Tyrrell, K. AU - Hardy, S. E. AU - Atkinson, H. H. AU - Yaffe, K. AU - Satterfield, S. PY - 2010 DA - 2010// TI - Executive function, memory, and gait speed decline in well-functioning older adults JO - J Gerontol A Biol Sci Med Sci VL - 65 UR - https://doi.org/10.1093/gerona/glq111 DO - 10.1093/gerona/glq111 ID - Watson2010 ER - TY - JOUR AU - Fiser, W. M. AU - Hays, N. P. AU - Rogers, S. C. AU - Kajkenova, O. AU - Williams, A. E. AU - Evans, C. M. AU - Evans, W. J. PY - 2010 DA - 2010// TI - Energetics of walking in elderly people: factors related to gait speed JO - J Gerontol A Biol Sci Med Sci VL - 65 UR - https://doi.org/10.1093/gerona/glq137 DO - 10.1093/gerona/glq137 ID - Fiser2010 ER - TY - JOUR AU - Bohannon, R. W. AU - Williams Andrews, A. PY - 2011 DA - 2011// TI - Normal walking speed: a descriptive meta-analysis JO - Physiotherapy VL - 97 UR - https://doi.org/10.1016/j.physio.2010.12.004 DO - 10.1016/j.physio.2010.12.004 ID - Bohannon2011 ER - TY - JOUR AU - Al Snih, S. AU - Fisher, M. N. AU - Raji, M. A. AU - Markides, K. S. AU - Ostir, G. V. AU - Goodwin, J. S. PY - 2005 DA - 2005// TI - Diabetes mellitus and incidence of lower body disability among older Mexican Americans JO - J Gerontol A Biol Sci Med Sci VL - 60 UR - https://doi.org/10.1093/gerona/60.9.1152 DO - 10.1093/gerona/60.9.1152 ID - Al Snih2005 ER - TY - JOUR AU - Ishizaki, T. AU - Furuna, T. AU - Yoshida, Y. AU - Iwasa, H. AU - Shimada, H. AU - Yoshida, H. AU - Kumagai, S. AU - Suzuki, T. PY - 2011 DA - 2011// TI - Declines in physical performance by sex and age among nondisabled community-dwelling older Japanese during a 6-year period JO - J Epidemiol VL - 21 UR - https://doi.org/10.2188/jea.JE20100138 DO - 10.2188/jea.JE20100138 ID - Ishizaki2011 ER - TY - JOUR AU - Semba, R. D. AU - Ferrucci, L. AU - Sun, K. AU - Walston, J. AU - Varadhan, R. AU - Guralnik, J. M. AU - Fried, L. P. PY - 2007 DA - 2007// TI - Oxidative stress and severe walking disability among older women JO - Am J Med VL - 120 UR - https://doi.org/10.1016/j.amjmed.2007.07.028 DO - 10.1016/j.amjmed.2007.07.028 ID - Semba2007 ER - TY - JOUR AU - Cesari, M. PY - 2011 DA - 2011// TI - Role of gait speed in the assessment of older patients JO - JAMA VL - 305 UR - https://doi.org/10.1001/jama.2010.1970 DO - 10.1001/jama.2010.1970 ID - Cesari2011 ER - TY - JOUR AU - Ferrucci, L. AU - Bandinelli, S. AU - Benvenuti, E. AU - Di Iorio, A. AU - Macchi, C. AU - Harris, T. B. AU - Guralnik, J. M. PY - 2000 DA - 2000// TI - Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study JO - J Am Geriatr Soc VL - 48 UR - https://doi.org/10.1111/j.1532-5415.2000.tb03873.x DO - 10.1111/j.1532-5415.2000.tb03873.x ID - Ferrucci2000 ER - TY - JOUR AU - Manini, T. M. AU - Clark, B. C. PY - 2012 DA - 2012// TI - Dynapenia and aging: an update JO - J Gerontol A Biol Sci Med Sci VL - 67 UR - https://doi.org/10.1093/gerona/glr010 DO - 10.1093/gerona/glr010 ID - Manini2012 ER - TY - JOUR AU - Deshpande, N. AU - Ferrucci, L. AU - Metter, J. AU - Faulkner, K. A. AU - Strotmeyer, E. AU - Satterfield, S. AU - Schwartz, A. AU - Simonsick, E. PY - 2008 DA - 2008// TI - Association of lower limb cutaneous sensitivity with gait speed in the elderly: the health ABC study JO - Am J Phys Med Rehabil VL - 87 UR - https://doi.org/10.1097/PHM.0b013e31818a5556 DO - 10.1097/PHM.0b013e31818a5556 ID - Deshpande2008 ER - TY - JOUR AU - Rosano, C. AU - Kuller, L. H. AU - Chung, H. AU - Arnold, A. M. AU - Longstreth, W. T. AU - Newman, A. B. PY - 2005 DA - 2005// TI - Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults JO - J Am Geriatr Soc VL - 53 UR - https://doi.org/10.1111/j.1532-5415.2005.53214.x DO - 10.1111/j.1532-5415.2005.53214.x ID - Rosano2005 ER - TY - JOUR AU - Rosano, C. AU - Aizenstein, H. AU - Brach, J. AU - Longenberger, A. AU - Studenski, S. AU - Newman, A. B. PY - 2008 DA - 2008// TI - Special article: gait measures indicate underlying focal gray matter atrophy in the brain of older adults JO - J Gerontol A Biol Sci Med Sci VL - 63 UR - https://doi.org/10.1093/gerona/63.12.1380 DO - 10.1093/gerona/63.12.1380 ID - Rosano2008 ER - TY - JOUR AU - Blanco, I. AU - Verghese, J. AU - Lipton, R. B. AU - Putterman, C. AU - Derby, C. A. PY - 2012 DA - 2012// TI - Racial differences in gait velocity in an urban elderly cohort JO - J Am Geriatr Soc VL - 60 UR - https://doi.org/10.1111/j.1532-5415.2012.03927.x DO - 10.1111/j.1532-5415.2012.03927.x ID - Blanco2012 ER - TY - JOUR AU - Delbaere, K. AU - Sturnieks, D. L. AU - Crombez, G. AU - Lord, S. R. PY - 2009 DA - 2009// TI - Concern about falls elicits changes in gait parameters in conditions of postural threat in older people JO - J Gerontol A Biol Sci Med Sci VL - 64 UR - https://doi.org/10.1093/gerona/gln014 DO - 10.1093/gerona/gln014 ID - Delbaere2009 ER - TY - JOUR AU - Coppin, A. K. AU - Ferrucci, L. AU - Lauretani, F. AU - Phillips, C. AU - Chang, M. AU - Bandinelli, S. AU - Guralnik, J. M. PY - 2006 DA - 2006// TI - Low socioeconomic status and disability in old age: evidence from the InChianti study for the mediating role of physiological impairments JO - J Gerontol A Biol Sci Med Sci VL - 61 UR - https://doi.org/10.1093/gerona/61.1.86 DO - 10.1093/gerona/61.1.86 ID - Coppin2006 ER - TY - JOUR AU - Brunner, E. AU - Shipley, M. AU - Spencer, V. AU - Kivimaki, M. AU - Chandola, T. AU - Gimeno, D. AU - Singh-Manoux, A. AU - Guralnik, J. AU - Marmot, M. PY - 2009 DA - 2009// TI - Social inequality in walking speed in early old age in the Whitehall II study JO - J Gerontol A Biol Sci Med Sci VL - 64 UR - https://doi.org/10.1093/gerona/glp078 DO - 10.1093/gerona/glp078 ID - Brunner2009 ER - TY - JOUR AU - Ferrucci, L. AU - Guralnik, J. M. AU - Studenski, S. AU - Fried, L. P. AU - Cutler, G. B. AU - Walston, J. D. PY - 2004 DA - 2004// TI - Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report JO - J Am Geriatr Soc VL - 52 UR - https://doi.org/10.1111/j.1532-5415.2004.52174.x DO - 10.1111/j.1532-5415.2004.52174.x ID - Ferrucci2004 ER - TY - JOUR AU - Folstein, M. F. AU - Folstein, S. E. AU - McHugh, P. R. PY - 1975 DA - 1975// TI - “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician JO - J Psychiatr Res VL - 12 UR - https://doi.org/10.1016/0022-3956(75)90026-6 DO - 10.1016/0022-3956(75)90026-6 ID - Folstein1975 ER - TY - JOUR AU - Yesavage, J. A. AU - Brink, T. L. AU - Rose, T. L. AU - Lum, O. AU - Huang, V. AU - Adey, M. AU - Leirer, V. O. PY - 1982 DA - 1982// TI - Development and validation of a geriatric depression screening scale: a preliminary report JO - J Psychiatr Res VL - 17 UR - https://doi.org/10.1016/0022-3956(82)90033-4 DO - 10.1016/0022-3956(82)90033-4 ID - Yesavage1982 ER - TY - JOUR AU - Yardley, L. AU - Beyer, N. AU - Hauer, K. AU - Kempen, G. AU - Piot-Ziegler, C. AU - Todd, C. PY - 2005 DA - 2005// TI - Development and initial validation of the Falls Efficacy Scale-International (FES-I) JO - Age Ageing VL - 34 UR - https://doi.org/10.1093/ageing/afi196 DO - 10.1093/ageing/afi196 ID - Yardley2005 ER - TY - JOUR AU - Delbaere, K. AU - Close, J. C. AU - Mikolaizak, A. S. AU - Sachdev, P. S. AU - Brodaty, H. AU - Lord, S. R. PY - 2010 DA - 2010// TI - The Falls Efficacy Scale International (FES-I). A comprehensive longitudinal validation study JO - Age Ageing VL - 39 UR - https://doi.org/10.1093/ageing/afp225 DO - 10.1093/ageing/afp225 ID - Delbaere2010 ER - TY - JOUR AU - Radloff, L. S. PY - 1977 DA - 1977// TI - The CES-D Scale: A Self-Report Depression Scale for Research in the General Population JO - Appl Psychol Meas VL - 1 UR - https://doi.org/10.1177/014662167700100306 DO - 10.1177/014662167700100306 ID - Radloff1977 ER - TY - JOUR AU - Katz, S. AU - Ford, A. B. AU - Moskowitz, R. W. AU - Jackson, B. A. AU - Jaffe, M. W. PY - 1963 DA - 1963// TI - Studies of Illness in the Aged. The Index of Adl: A Standardized Measure of Biological and Psychosocial Function JO - JAMA VL - 185 UR - https://doi.org/10.1001/jama.1963.03060120024016 DO - 10.1001/jama.1963.03060120024016 ID - Katz1963 ER - TY - JOUR AU - Fried, L. P. AU - Tangen, C. M. AU - Walston, J. AU - Newman, A. B. AU - Hirsch, C. AU - Gottdiener, J. AU - Seeman, T. AU - Tracy, R. AU - Kop, W. J. AU - Burke, G. PY - 2001 DA - 2001// TI - Frailty in older adults: evidence for a phenotype JO - J Gerontol A Biol Sci Med Sci VL - 56 UR - https://doi.org/10.1093/gerona/56.3.M146 DO - 10.1093/gerona/56.3.M146 ID - Fried2001 ER - TY - BOOK AU - Hair, J. F. AU - Black, B. AU - Babin, B. AU - Anderson, R. E. AU - Tathan, R. L. PY - 2006 DA - 2006// TI - Multivariate Data Analysis PB - Prentice Hall CY - (Pearson Education) ID - Hair2006 ER - TY - JOUR AU - Visser, M. AU - Goodpaster, B. H. AU - Kritchevsky, S. B. AU - Newman, A. B. AU - Nevitt, M. AU - Rubin, S. M. AU - Simonsick, E. M. AU - Harris, T. B. PY - 2005 DA - 2005// TI - Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons JO - J Gerontol A Biol Sci Med Sci VL - 60 UR - https://doi.org/10.1093/gerona/60.3.324 DO - 10.1093/gerona/60.3.324 ID - Visser2005 ER - TY - JOUR AU - Cummings, S. R. AU - Black, D. M. AU - Nevitt, M. C. AU - Browner, W. S. AU - Cauley, J. A. AU - Genant, H. K. AU - Mascioli, S. R. AU - Scott, J. C. AU - Seeley, D. G. AU - Steiger, P. PY - 1990 DA - 1990// TI - Appendicular bone density and age predict hip fracture in women.The Study of Osteoporotic Fractures Research Group JO - JAMA: the journal of the American Medical Association VL - 263 UR - https://doi.org/10.1001/jama.1990.03440050059033 DO - 10.1001/jama.1990.03440050059033 ID - Cummings1990 ER - TY - JOUR AU - Telles, E. E. AU - Lim, N. PY - 1998 DA - 1998// TI - Does it matter who answers the race question? Racial classification and income inequality in Brazil JO - Demography VL - 35 UR - https://doi.org/10.2307/3004014 DO - 10.2307/3004014 ID - Telles1998 ER - TY - JOUR AU - Menz, H. B. AU - Lord, S. R. AU - Fitzpatrick, R. C. PY - 2003 DA - 2003// TI - Age-related differences in walking stability JO - Age Ageing VL - 32 UR - https://doi.org/10.1093/ageing/32.2.137 DO - 10.1093/ageing/32.2.137 ID - Menz2003 ER - TY - JOUR AU - Kim, T. N. AU - Park, M. S. AU - Yang, S. J. AU - Yoo, H. J. AU - Kang, H. J. AU - Song, W. AU - Seo, J. A. AU - Kim, S. G. AU - Kim, N. H. AU - Baik, S. H. PY - 2010 DA - 2010// TI - Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS) JO - Diabetes Care VL - 33 UR - https://doi.org/10.2337/dc09-2310 DO - 10.2337/dc09-2310 ID - Kim2010 ER - TY - JOUR AU - De Rekeneire, N. AU - Resnick, H. E. AU - Schwartz, A. V. AU - Shorr, R. I. AU - Kuller, L. H. AU - Simonsick, E. M. AU - Vellas, B. AU - Harris, T. B. PY - 2003 DA - 2003// TI - Diabetes is associated with subclinical functional limitation in nondisabled older individuals: the Health, Aging, and Body Composition study JO - Diabetes Care VL - 26 UR - https://doi.org/10.2337/diacare.26.12.3257 DO - 10.2337/diacare.26.12.3257 ID - De Rekeneire2003 ER - TY - JOUR AU - Allet, L. AU - Armand, S. AU - Golay, A. AU - Monnin, D. AU - de Bie, R. A. AU - de Bruin, E. D. PY - 2008 DA - 2008// TI - Gait characteristics of diabetic patients: a systematic review JO - Diabetes Metab Res Rev VL - 24 UR - https://doi.org/10.1002/dmrr.809 DO - 10.1002/dmrr.809 ID - Allet2008 ER - TY - JOUR AU - Cordeiro, R. C. AU - Jardim, J. R. AU - Perracini, M. R. AU - Ramos, L. R. PY - 2009 DA - 2009// TI - Factors associated with functional balance and mobility among elderly diabetic outpatients JO - Arq Bras Endocrinol Metabol VL - 53 UR - https://doi.org/10.1590/S0004-27302009000700007 DO - 10.1590/S0004-27302009000700007 ID - Cordeiro2009 ER - TY - JOUR AU - Chen, G. AU - Patten, C. AU - Kothari, D. H. AU - Zajac, F. E. PY - 2005 DA - 2005// TI - Gait differences between individuals with post-stroke hemiparesis and non-disabled controls at matched speeds JO - Gait Posture VL - 22 UR - https://doi.org/10.1016/j.gaitpost.2004.06.009 DO - 10.1016/j.gaitpost.2004.06.009 ID - Chen2005 ER - TY - JOUR AU - Hsu, A. L. AU - Tang, P. F. AU - Jan, M. H. PY - 2003 DA - 2003// TI - Analysis of impairments influencing gait velocity and asymmetry of hemiplegic patients after mild to moderate stroke JO - Arch Phys Med Rehabil VL - 84 UR - https://doi.org/10.1016/S0003-9993(03)00030-3 DO - 10.1016/S0003-9993(03)00030-3 ID - Hsu2003 ER - TY - JOUR AU - Wijlhuizen, G. J. AU - Chorus, A. M. AU - Hopman-Rock, M. PY - 2008 DA - 2008// TI - Fragility, fear of falling, physical activity and falls among older persons: some theoretical considerations to interpret mediation JO - Prev Med VL - 46 UR - https://doi.org/10.1016/j.ypmed.2008.01.016 DO - 10.1016/j.ypmed.2008.01.016 ID - Wijlhuizen2008 ER - TY - JOUR AU - Ainsworth, B. E. AU - Haskell, W. L. AU - Whitt, M. C. AU - Irwin, M. L. AU - Swartz, A. M. AU - Strath, S. J. AU - O’Brien, W. L. AU - Bassett, D. R. AU - Schmitz, K. H. AU - Emplaincourt, P. O. PY - 2000 DA - 2000// TI - Compendium of physical activities: an update of activity codes and MET intensities JO - Med Sci Sports Exerc VL - 32 UR - https://doi.org/10.1097/00005768-200009001-00009 DO - 10.1097/00005768-200009001-00009 ID - Ainsworth2000 ER - TY - JOUR AU - Kelly, J. O. AU - Kilbreath, S. L. AU - Davis, G. M. AU - Zeman, B. AU - Raymond, J. PY - 2003 DA - 2003// TI - Cardiorespiratory fitness and walking ability in subacute stroke patients JO - Arch Phys Med Rehabil VL - 84 UR - https://doi.org/10.1016/S0003-9993(03)00376-9 DO - 10.1016/S0003-9993(03)00376-9 ID - Kelly2003 ER - TY - JOUR AU - Dumurgier, J. AU - Elbaz, A. AU - Ducimetiere, P. AU - Tavernier, B. AU - Alperovitch, A. AU - Tzourio, C. PY - 2009 DA - 2009// TI - Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study JO - BMJ VL - 339 UR - https://doi.org/10.1136/bmj.b4460 DO - 10.1136/bmj.b4460 ID - Dumurgier2009 ER - TY - JOUR AU - Jenkins, K. R. AU - Fultz, N. H. PY - 2005 DA - 2005// TI - Functional impairment as a risk factor for urinary incontinence among older Americans JO - Neurourol Urodyn VL - 24 UR - https://doi.org/10.1002/nau.20089 DO - 10.1002/nau.20089 ID - Jenkins2005 ER - TY - JOUR AU - Wyman, J. F. AU - Elswick, R. K. AU - Ory, M. G. AU - Wilson, M. S. AU - Fantl, J. A. PY - 1993 DA - 1993// TI - Influence of functional, urological, and environmental characteristics on urinary incontinence in community-dwelling older women JO - Nurs Res VL - 42 UR - https://doi.org/10.1097/00006199-199309000-00004 DO - 10.1097/00006199-199309000-00004 ID - Wyman1993 ER - TY - JOUR AU - Markland, A. D. AU - Richter, H. E. AU - Fwu, C. W. AU - Eggers, P. AU - Kusek, J. W. PY - 2011 DA - 2011// TI - Prevalence and trends of urinary incontinence in adults in the United States, 2001 to 2008 JO - J Urol VL - 186 UR - https://doi.org/10.1016/j.juro.2011.03.114 DO - 10.1016/j.juro.2011.03.114 ID - Markland2011 ER - TY - JOUR AU - Thirugnanasothy, S. PY - 2010 DA - 2010// TI - Managing urinary incontinence in older people JO - BMJ VL - 341 UR - https://doi.org/10.1136/bmj.c3835 DO - 10.1136/bmj.c3835 ID - Thirugnanasothy2010 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/13/182/prepub UR - http://www.biomedcentral.com/1471-2458/13/182/prepub ID - ref52 ER -