Health-related quality of life in adolescents with screening-detected celiac disease, before and one year after diagnosis and initiation of gluten-free diet, a prospective nested case-referent study

Table 1 Adolescents reporting problems (EQ-5D), before and 1 year after screening-detected celiac disease diagnosis, compared to referents without celiac disease

Dimensions at Baseline and Follow–up	Screening-detected CD (casesn = 103)	Non CD (referentsn = 483)	Odds Ratios (95% CI)^a
	n (%) with problems	n (%) with problems	Bivariate LR^b	Multivariate LR^c
Mobility
Baseline	3 (2.9)	11 (2.3)	0.78 (0.21-2.84)	1.28 (0.35-4.68)
Follow-up	1 (1.0)	7 (1.4)	0.67 (0.08-5.48)	0.67 (0.08-5.52)
Self care
Baseline	0 0	2 (0.4)	0.00 (0.00-)	0.00 (0.00-)
Follow-up	0 0	2 (0.4)	0.00 (0.00-)	0.00 (0.00-)
Activity
Baseline	3 (2.9)	13 (2.7)	0.92 (0.26-3.30)	1.09 (0.31-3.91)
Follow-up	2 (1.9)	11 (2.3)	0.85 (0.19-3.89)	0.85 (0.18-3.88)
Pain
Baseline	21 (20.4)	95 (19.7)	0.96 (0.56-1.62)	1.18 (0.69-2.02)
Follow-up	13 (12.6)	106 (21.9)	0.51 (0.28-0.96)	0.50 (0.27-0.94)
Anxiety/Depression
Baseline	13 (12.6)	52 (10.8)	0.84 (0.44-1.60)	1.37 (0.70-2.69)
Follow-up	15 (14.6)	95 (19.7)	0.70 (0.39-1.26)	0.65 (0.35-1.20)

^a Odds ratio (95% confidence interval).
^b Bivariate logistic regression using case/referent and problems reported.
^c Multivariate logistic regression using case/referent and problems reported at baseline and problems reported at follow-up.

ISSN: 1471-2458