Control | Fish | Fish + S | pvalues | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 3 months | 12 months | Baseline | 3 months | 12 months | Baseline | 3 months | 12 months | Time | Group | Interaction | |
Mixed model with all available data only | ||||||||||||
n | 39 | 29 | 18 | 39 | 30 | 25 | 40 | 28 | 20 | - | - | - |
Mean ± SD | 88.5 ± 12.7 | 84.2 ± 12.6 | 81.7 ± 14.1 | 90.0 ± 12.2 | 84.8 ± 12.3 | 80.9 ± 12.7 | 88.5 ± 11.4 | 82.9 ± 11.7 | 84.3 ± 11.7 | < 0.001 | 0.682 | 0.326 |
< 0.001‡ | 0.617‡ | 0.338‡ | ||||||||||
Mixed model with missing values imputed | ||||||||||||
n | 39 | 39 | 39 | 39 | 39 | 39 | 40 | 40 | 40 | - | - | - |
Mean ± SD | 88.5 ± 12.7 | 83.7 ± 12.0 | 82.9 ± 13.0 | 90.0 ± 12.2 | 86.0 ± 12.3 | 84.7 ± 13.2 | 88.5 ± 11.4 | 83.8 ± 11.3 | 83.7 ± 11.3 | < 0.001 | 0.767 | 0.803 |
LOCF # | ||||||||||||
n | 39 | 39 | 39 | 39 | 39 | 39 | 40 | 40 | 40 | - | - | - |
Mean ± SD | 88.5 ± 12.7 | 84.6 ± 12.1 | 83.9 ± 12.7 | 90.0 ± 12.2 | 86.7 ± 12.8 | 85.7 ± 13.6 | 88.5 ± 11.4 | 85.2 ± 11.5 | 85.3 ± 11.7 | < 0.001 | 0.805 | 0.457 |
BOCF # | ||||||||||||
n | 39 | 39 | 39 | 39 | 39 | 39 | 40 | 40 | 40 | - | - | - |
Mean ± SD | 88.5 ± 12.7 | 84.6 ± 12.1 | 84.8 ± 13.1 | 90.0 ± 12.2 | 86.7 ± 12.8 | 86.0 ± 14.0 | 88.5 ± 11.4 | 85.2 ± 11.5 | 86.0 ± 11.2 | < 0.001 | 0.840 | 0.348 |
Completers only # | ||||||||||||
n | 18 | 18 | 18 | 25 | 25 | 25 | 20 | 20 | 20 | - | - | - |
Mean ± SD | 89.5 ± 13.9 | 83.2 ± 13.0 | 81.7 ± 14.1 | 87.1 ± 11.8 | 82.5 ± 11.8 | 80.9 ± 12.7 | 89.4 ± 12.3 | 84.2 ± 11.4 | 84.3 ± 11.7 | < 0.001 | 0.799 | 0.141 |