Baseline (week −2)
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Withdrawal-oriented behavioural support
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• Baseline questionnaire [demographics, smoking history, Fagerstrom Test for Nicotine Dependence (FTND)]
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• Mood and Physical Symptoms Scale (MPSS)
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• Exhaled carbon monoxide (CO)
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• Attentional bias assessment (visual probe and Stroop tasks)
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Pre-quit visit (week −1) Randomisation week
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1 week supply nicotine patches Withdrawal-oriented behavioural support Intervention group receives attentional retraining (AR). Control group receives placebo training (PT)
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• CO
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• MPSS
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• VAS measure of craving (pre & post cue exposure task)
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Quit day (week 0)
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1 week supply nicotine patches Withdrawal-oriented behavioural support Intervention group receives AR Control group receives PT
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• CO
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• MPSS
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Post-quit visits (weeks +1, +2, +3)
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1 week supply nicotine patches Withdrawal-oriented behavioural support Intervention group receives AR. Control group receives PT
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• CO
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• MPSS
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• Lapses recorded on electronic diary
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Week +4 post-quit visit
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4 week supply nicotine patches Withdrawal-oriented behavioural support
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• CO
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• MPSS
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• Attentional bias assessment (visual probe and Stroop tasks)
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• VAS measure of craving (pre & post cue exposure task)
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• Group allocation assessment
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• Lapses recorded on electronic diary (up to +5 weeks) thereafter reported in clinic CRF
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Week +8 post-quit visit
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4 week supply transdermal nicotine patches (where eligible)
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• CO
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• MPSS
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• Attentional bias assessment (visual probe and Stroop tasks)
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• VAS measure of craving (pre & post cue exposure task)
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• Lapses reported in clinic CRF
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3 months post-quit visit
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• CO
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• MPSS
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• Attentional bias assessment
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• (visual probe and Stroop tasks)
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• VAS measure of craving (pre & post cue exposure task)
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• Lapses reported in clinic CRF
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6 months post-quit visit
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• CO
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• MPSS
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• Attentional bias assessment (visual probe and pictorial Stroop tasks)
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• VAS measure of craving (pre & post cue exposure task)
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• Lapses reported in clinic CRF
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• Patient satisfaction questionnaire
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