Skip to main content

Table 1 Parameters used in the economic model

From: Effect of breastfeeding promotion interventions on cost-effectiveness of rotavirus immunization in Indonesia

Parameters Base-case value Distribution References
Vaccine coverage 94% Triangular (89%; 94%; 99%) [22]
Vaccine efficacy in formula-fed infants    
 Mild 70.0% Triangular (66.5%; 70.0%; 73.5%) [7]
 Moderate 70.0% Triangular (66.5%; 70.0%; 73.5%)  
 Severe 84.0% Triangular (79.8%; 84.0%; 88.2%)  
 Death 76.5% Triangular (72.7%; 76.5%; 80.3%)  
Vaccine efficacy in breast-fed infants    
 Mild 63.1% Triangular (59.9%; 63.1%; 66.2%) [6, 7, 9]; calculated
 Moderate 63.1% Triangular (59.9%; 63.1%; 66.2%)  
 Severe 75.7% Triangular (71.9%; 75.7%; 79.5%)  
 Death 68.9% Triangular (65.5%; 68.9%; 72.4%)  
Rotavirus-diarrhea cases    
Base-case    
 EBF 15,626 Normalised mean: 15,626 (90%CI; 15,382-15,871) [7, 9, 1416, 20]; calculated
 PBF 452,658 Normalised mean: 452,658 (90%CI; 451,412-453,903)  
 NBF 450,261 Normalised mean: 450,261 (90%CI; 449,018-451,504)  
Education    
 EBF 36,674 Normalised mean: 36,674 (90%CI; 36,300-37,047) [7, 9, 10, 1416, 20]; calculated
 PBF 420,264 Normalised mean: 420,264 (90%CI; 419,058-421,469)  
 NBF 442,056 Normalised mean: 442,056 (90%CI; 440,824-443,289)  
Support    
 EBF 38,321 Normalised mean: 38,321 (90%CI; 37,940-38,703) [3, 7, 9, 1416, 18, 20]; calculated
 PBF 422,586 Normalised mean: 422,586 (90%CI; 421,378-423,795)  
 NBF 441,548 Normalised mean: 441,548 (90%CI; 440,316-442,780)  
Combined Effects    [7, 9, 1416, 18, 20]; calculated
 EBF 57,824 Normalised mean: 57,824 (90%CI; 57,356-58,292)  
 PBF 394,543 Normalised mean: 394,543 (90%CI; 393,371-395,715)  
 NBF 433,441 Normalised mean: 433,441 (90%CI; 432,220-434,663)  
Utility losses    
 Mild 0.00164 Triangular (using 25% lower and upper) [16, 20]
 Moderate 0.00548   
 Severe 0.02110   
 Death 1.00000   
Total medical direct costs per case (healthcare perspective, US$)    
 Mild 1.08 Triangular (1.08; 1.44; 1.80) [23]
 Moderate 4.31 Triangular (3.23; 4.31; 5.39) [7]
 Severe 41.72 Triangular (31.29; 41.72; 52.15) [7]
Total direct and indirect costs per case (societal perspective, US$)    
 Mild 2.81 Triangular (2.11; 2.81; 3.52) [23]
 Moderate 5.69 Triangular (4.27; 5.69; 7.11) [7]
 Severe 56.34 Triangular (42.25; 56.34; 70.42) [7]
Total vaccination and administration cost (per child, US$)    
 3-dose, Market price 15.50 Alternative scenario [7, 20]
Discount rate 3% Unvaried [14, 20]