Table 1 Parameters used in the economic model
Parameters | Base-case value | Distribution | References |
|---|---|---|---|
Vaccine coverage | 94% | Triangular (89%; 94%; 99%) | [22] |
Vaccine efficacy in formula-fed infants | |||
Mild | 70.0% | Triangular (66.5%; 70.0%; 73.5%) | [7] |
Moderate | 70.0% | Triangular (66.5%; 70.0%; 73.5%) | |
Severe | 84.0% | Triangular (79.8%; 84.0%; 88.2%) | |
Death | 76.5% | Triangular (72.7%; 76.5%; 80.3%) | |
Vaccine efficacy in breast-fed infants | |||
Mild | 63.1% | Triangular (59.9%; 63.1%; 66.2%) | |
Moderate | 63.1% | Triangular (59.9%; 63.1%; 66.2%) | |
Severe | 75.7% | Triangular (71.9%; 75.7%; 79.5%) | |
Death | 68.9% | Triangular (65.5%; 68.9%; 72.4%) | |
Rotavirus-diarrhea cases | |||
Base-case | |||
EBF | 15,626 | Normalised mean: 15,626 (90%CI; 15,382-15,871) | |
PBF | 452,658 | Normalised mean: 452,658 (90%CI; 451,412-453,903) | |
NBF | 450,261 | Normalised mean: 450,261 (90%CI; 449,018-451,504) | |
Education | |||
EBF | 36,674 | Normalised mean: 36,674 (90%CI; 36,300-37,047) | |
PBF | 420,264 | Normalised mean: 420,264 (90%CI; 419,058-421,469) | |
NBF | 442,056 | Normalised mean: 442,056 (90%CI; 440,824-443,289) | |
Support | |||
EBF | 38,321 | Normalised mean: 38,321 (90%CI; 37,940-38,703) | |
PBF | 422,586 | Normalised mean: 422,586 (90%CI; 421,378-423,795) | |
NBF | 441,548 | Normalised mean: 441,548 (90%CI; 440,316-442,780) | |
Combined Effects | |||
EBF | 57,824 | Normalised mean: 57,824 (90%CI; 57,356-58,292) | |
PBF | 394,543 | Normalised mean: 394,543 (90%CI; 393,371-395,715) | |
NBF | 433,441 | Normalised mean: 433,441 (90%CI; 432,220-434,663) | |
Utility losses | |||
Mild | 0.00164 | Triangular (using 25% lower and upper) | |
Moderate | 0.00548 | ||
Severe | 0.02110 | ||
Death | 1.00000 | ||
Total medical direct costs per case (healthcare perspective, US$) | |||
Mild | 1.08 | Triangular (1.08; 1.44; 1.80) | [23] |
Moderate | 4.31 | Triangular (3.23; 4.31; 5.39) | [7] |
Severe | 41.72 | Triangular (31.29; 41.72; 52.15) | [7] |
Total direct and indirect costs per case (societal perspective, US$) | |||
Mild | 2.81 | Triangular (2.11; 2.81; 3.52) | [23] |
Moderate | 5.69 | Triangular (4.27; 5.69; 7.11) | [7] |
Severe | 56.34 | Triangular (42.25; 56.34; 70.42) | [7] |
Total vaccination and administration cost (per child, US$) | |||
3-dose, Market price | 15.50 | Alternative scenario | |
Discount rate | 3% | Unvaried |