Incidence of complications in children with laboratory-confirmed influenza. ED = emergency department; GI = gastrointestinal. Notes: Confidence intervals were not presented for any of these values within any of the source articles. We calculated the rate of acute otitis media for the placebo group from the Heinonen et al.  article as follows: (6 [the number of patients with acute otitis media at baseline] + 19 [the number of the number of patients with new episodes of acute otitis media during the study]) ÷ 61 [the total number of patients in the placebo group] = 40.9%.