Table 7 The effect of major input parameters on the estimated cost-effectiveness of adding vaccination to screening
ΔQALY | Δcost ($) | ICER ($/QALY) | |
|---|---|---|---|
base case | 0.01016 | 280.396 | 27 588 |
no herd immunity | 0.00857 | 364.382 | 42 520 |
with intention-to-treat efficacy parameter | 0.00982 | 281.534 | 28 662 |
with cross-protection | 0.01102 | 277.560 | 25 190 |
50% waning of efficacy from 20 to 30 years after vaccination and booster dose in 80% of persons immunized at age 12 years and alive after 20 years | 0.00728 | 332.731 | 45 709 |
discount rate 5% | 0.00532 | 295.598 | 55 617 |
price of the vaccine 231$* | 0.01016 | 520.210 | 51 184 |