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Table 4 Hazard Ratio (HR) and 95% Confidence Intervals (CI) for risk of all-cause, cancer-specific, and circulatory death, stratified by Charlson Comorbidity index

From: Ability of a biomarker-based score to predict death from circulatory disease and cancer in NHANES III

  Total Men Women
All-cause Cancer Circulatory All-cause Cancer Circulatory All-cause Cancer Circulatory
HR 95%CI HR 95%CI HR 95%CI HR 95%CI HR 95%CI HR 95%CI HR 95%CI HR 95%CI HR 95%CI
Comorbidity Index <3                 
Score=0 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref
Score=1 1.30 1.07, 1.58 0.97 0.70, 1.36 1.47 1.09, 1.98 1.22 0.85, 1.58 1.30 0.91, 1.85 1.12 0.78, 1.60 1.41 1.00, 1.99 0.63 0.29, 1.36 2.15 1.21, 3.72
Score=2 1.85 1.45, 2.38 1.23 0.68, 2.21 2.73 1.68, 4.43 1.53 1.14, 2.00 0.83 0.50, 1.37 2.25 1.40, 3.62 3.05 2.05, 4.52 2.50 0.93, 6.71 4.30 1.94, 9.53
Score=3 3.16 2.03, 4.94 0.64 0.16, 2.50 1.06 0.30, 3.75 3.30 1.94, 5.64 0.63 0.12, 3.27 0.87 0.22, 3.44 1.89 0.52, 6.79 0.52 0.06, 4.84 1.32 0.08, 22.13
Score=4 13.32 6.15, 28.87    17.66 9.86, 31.64 11.27 5.72, 22.22    19.20 9.17, 40.20       
P for trend <0.001 0.844 <0.001 0.002 0.938 0.009 <0.001 0.692 0.001
Comorbidity Index =3                 
Score=0 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref
Score=1 1.30 1.07, 1.57 1.31 0.87, 1.96 1.15 0.81, 1.62 1.18 0.93, 1.43 1.54 1.00, 2.37 1.43 1.06, 1.92 0.99 0.81, 1.19 0.84 0.43, 1.63 1.08 0.85, 1.39
Score=2 1.98 1.60, 2.44 1.29 0.80, 2.08 2.18 1.63, 2.90 1.81 1.08, 2.19 1.93 0.97, 3.85 1.35 0.99, 1.86 2.47 1.74, 3.50 1.04 0.44, 2.43 2.26 1.58, 3.23
Score=3 2.52 1.99, 3.18 3.27 2.07, 5.17 2.38 1.28, 4.41 3.57 3.57, 9.86 4.36 1.86, 10.23 5.96 2.10, 16.92 3.69 1.81, 7.55    6.66 1.97, 22.50
Score=4 10.22 5.08, 20.58 3.66 1.93, 6.95 16.55 6.66, 41.11 6.23 2.14, 15.81    0.64 0.09, 4.85 9.14 6.71, 12.46 9.36 3.73, 23.52 4.55 1.09, 18.99
P for trend <0.001 0.009 <0.001 <0.001 0.001 0.001 <0.001 0.777 <0.001
Comorbidity Index =4                 
Score=0 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref 1.00 Ref
Score=1 1.30 1.07, 1.58 0.97 0.70, 1.36 1.47 1.09, 1.98 1.22 0.85, 1.58 0.93 0.56, 1.56 1.07 0.71, 1.62 1.41 1.11, 1.78 1.72 0.88, 3.33 1.25 0.84, 1.86
Score=2 1.85 1.45, 2.38 1.23 0.68, 2.21 2.73 1.68, 4.43 1.53 1.14, 2.00 0.68 0.35, 1.35 2.04 1.29, 3.24 2.16 1.57, 2.98 2.06 0.98, 4.37 2.28 1.42, 3.65
Score=3 3.16 2.03, 4.94 0.64 0.16, 2.50 1.06 0.30, 3.75 3.30 1.94, 5.64 3.51 1.66, 7.44 3.85 1.79, 8.29 1.60 1.02, 2.53 3.04 1.41, 6.53 0.71 0.23, 2.20
Score=4 13.32 6.15, 28.87    17.66 9.86, 31.64 11.27 5.72, 22.22    10.76 5.29, 21.89 14.44 6.11, 34.15 5.85 2.61, 13.09 26.72 7.81, 91.37
P for trend <0.001 0.003 <0.001 <0.001 0.965 <0.001 <0.001 0.003 0.002
  1. All models were adjusted for age, gender, poverty to income ratio, race ethnicity group, smoking behavior, alcohol consumption, vigorous physical activity, and BMI.