Modeling the impact of the difference in cross-protection data between a human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and a human papillomavirus (HPV)-6/11/16/18 vaccine in Canada

Table 1 Overview of provincial vaccination program policies and target population inputs for the budget impact analysis

Province	Publicly funded HPV vaccination females*	Start of vaccination program†	Assumed target age groups modelled for 2011/12 school year	Coverage	Size of target population	Number of females Vaccinated/Year
British Columbia	Grade 6	2008-09	11 years	66% [12]^a	24 027	15 858
	2008 – 2010 Only: Grade 9 Catch-up program [11] 2+1 Dosing strategy used
Alberta	Grade 5	2008-09	10; 14; 15; 16 years	50%^a	10 years: 19 489	10 years: 9 745
	Sept 2009 to June 2012 Only: Age 14–16 years Catch-up program [13]
					14 years: 21 967	14 years: 10 984
					15 years: 22 563‡	15 years: 5 790
					16 years: 22 969 ‡	16 years: 3 060
Saskatchewan	Grade 6 or beyond with a date of birth no earlier than January 1, 1996. [14]	2008-09	11 years	85%^a	5 652	4 760
Manitoba	Grade 6 [15]	2008-09	11 years	55%^a	6 504	3 577
Ontario	Grade 8 [16]	2007-08	13 years	53% [17]^a	74 048	39 246
Quebec	Grade 4 (2-dose in Grade 4 with booster in Grade 9) Grade 9 catch-up [18]	2008-09	9 years	76% [19]	9 years: 40 099	9 years: 30 476
			14 years		14 years: 46 756	14 years: 35 534
Newfoundland and Labrador	Grade 6[20] 2008–10 Only: Grade 9 catch-up cohort	2007-08	11 years	83%^a	2 710	2 249
New Brunswick	Grade 7,	2008-09	12 years	85%^a	4 080	3 468
	2008–09 Only: Grade 8 catch-up [21]		13 years (2008 Only)
Nova Scotia	Grade 7 [22]	2007-08	12 years	80% [17]^a	5 192	4 154
Prince Edward Island	Grade 6 [23]	2007-08	11 years	80% [17]^a	723	578

* Women in the catch-up program are assumed to receive the same number of doses as those in the primary target population. Unless stated that a 2+1 dosing schedule is recommended, the provinces have adopted the recommended 3-dose schedule for the vaccines.
† The catch-up programs may have been initiated after the primary vaccination program began or implemented in selected school years only. For this analysis, only catch-up programs in the 2011/12 school year were modelled.
‡ In order to determine the number of women eligible for vaccination, the budget impact model calculates the number of women vaccinated since the implementation of the vaccination program in each province. Although there are expected to be 22 563 15-year olds and 22 969 16-year olds in Alberta in 2011, 10 983 and 16 849 respectively are expected to be vaccinated prior to the 2011/12 school year. Therefore, only 11 580 15-year olds and 6 120 16-year olds are eligible for the catch-up program targeting these age groups.
^a Coverage estimated by local experts unless otherwise specified.