Figure 3

Incremental cost effectiveness plane for vaccination of 100,000 12 year-olds with the HPV-16/18 AS04-adjuvanted vaccine compared with the HPV-6/11/16/18 vaccine across a lifetime time horizon (discounted). Each dot on the graph represents the relative discounted costs (per 100,000 Canadian dollars (CDN)) and discounted quality adjusted life years (QALY) of one out of the 10,000 completed simulations. The difference in discounted costs and QALYs is calculated by subtracting the HPV-6/11/16/18 vaccine (Vaccine B) from the HPV-16/18 AS04-adjuvanted vaccine (Vaccine A) values (e.g. A – B). Quadrant I contains scenarios where the HPV-16/18 AS04-adjuvanted vaccine is associated with greater lifetime costs and more QALYs saved (0.3% of simulations). Quadrant II contains scenarios where the HPV-16/18 AS04-adjuvanted vaccine is associated with lower lifetime costs and more QALYs saved (C is dominant: 48.7% of simulations). Quadrant III contains scenarios where the HPV-6/11/16/18 vaccine is associated with greater lifetime costs and more QALYs saved (34.8% of simulations). Quadrant IV contains scenarios where the HPV-6/11/16/18 vaccine is associated with lower lifetime costs and more QALYs saved (G is dominant: 16.3% of simulations).