Hospital factors and patient characteristics in the treatment of colorectal cancer: a population based study

BMC Public Health

Table 4 Postoperative in-hospital mortality in 22289 incident colorectal cancer patients after curative surgery

	Total (N = 22289)	Unadjusted mortality	Random-effect model*
	No.	%	OR	95% CI	P
Age (years)
≤60	3,910	1.0	1
61-70	6,224	1.9	1.76	(1.20-2.57)	<0.001
71-80	8,124	4.0	2.30	(1.61-3.28)
>80	4,031	8.9	3.34	(2.33-4.79)
Gender
Male	12,309	4.0	1		0.36
Female	9,980	3.5	0.71	(0.60-0.84)
Educational level
Secondary or more	3,165	1.2	1		<0.001
Intermediate	4,745	2.6	1.14	(0.82-1.58)
Primary	11,625	4.4	1.25	(0.95-1.67)
Unknown	2,754	5.2	1.60	(1.10-2.32)
Marital status
Married	14,221	3.1	1		<0.001
Unmarried	6,212	5.0	1.32	(1.09-1.59)
Unknown	1,856	5.5	1.65	(1.20-2.29)
OPE
No	14,558	1.8	1		<0.001
Yes	7,731	7.5	1.54	(1.29-1.85)
Disease staging
Absence of metastases	19,064	3.5	-		<0.001
Presence of metastases	3,225	5.7	-
Comorbidity (Charlson index)
0	16,145	3.2	-		<0.001
≥1	6,144	5.4	-
Year of admission
2000	2,458	4.1	1		0.55
2001	2,583	3.4	0.82	(0.59-1.14)
2002	2,651	4.1	0.95	(0.69-1.29)
2003	2,687	3.9	0.75	(0.55-1.03)
2004	2,924	4.4	0.77	(0.57-1.05)
2005	2,930	3.3	0.53	(0.38-0.73)
2006	3,006	3.5	0.54	(0.39-0.74)
2007	3,050	3.6	0.49	(0.34-0.68)
Tumor site
Colon	15,256	4.1	1		<0.001
Rectum	7,033	3.1	1.05	(0.87-1.27)
Hospital volume (annual caseload)
>60	9,371	3.5	1		0.10
26-60	9,430	3.9	0.87	(0.64-1.19)
<25	3,488	4.3	1.14	(0.76-1.69)
APR-DRG risk-of-mortality score
Low	12,740	0.8	1		<0.001
Medium	7,869	3.9	4.47	(3.54-5.66)
High	1,359	19.1	25.77	(19.80-33.54)
Extreme	321	56.7	153.03	(109.81-213.27)

*Given the correlation between APR-DRG risk-of-mortality score, tumor stage and comorbidity score these predictors were not included in the models simultaneously.
‡Unmarried includes single, separated, divorced and widowed.
OR: odds ratio; CI: confidence interval; APR-DRG: all-patient-refined-diagnosis-related group; OPE: obstruction, perforation or emergency admission.

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