Figure 1

Effect of POP mixtures on insulin action. Differentiated 3T3-L1 adipoctytes were incubated for 48 h with different POP mixtures mimicking those present in the oil of farmed Atlantic salmon. The ability of insulin (30nM) to stimulate glucose uptake was assessed. Note that the PCDF mixture and its elevated TEQ value did not impair insulin-stimulated glucose uptake. At the opposite, PCB mixtures and their low TEQ values significantly impaired insulin action. The most important inhibitory effect on insulin action was observed after exposure to organochlorine pesticides (1nM). PCDDs, polychlorinated dibenzo-p-dioxins; PCDFs, polychlorinated dibenzofurans; PCBs, polychlorinated biphenyls; OPs, organochlorine pesticides. Data are expressed as relative glucose uptake and presented as mean ± SEM. *p < 0.05; Data are adapted from [44].