Dependent variables | Time period | Factored ARIMA model* | Independent variables† | Coefficients‡ | p value |
---|---|---|---|---|---|
Primary analyses | |||||
ACEIs | Jan 1997 toDec 2008 | p = (1)(12); | Constant | 4,509,908 | <0.0001 |
q = (1)(9) | Baseline trend | 66,568 | <0.0001 | ||
PA2000 level change | -592,252 | 0.0151 | |||
PA2003 level change | -1,255,287 | <0.0001 | |||
PA2004 trend change | -96,582 | <0.0001 | |||
PA2006 level change | -1,545,767 | <0.0001 | |||
CNY | -351,216 | 0.0029 | |||
ARB | Feb 1998 toDec 2008 | p = (12); | Baseline trend | 92,537 | <0.0001 |
q = (2) | PA2001 trend change | 160,472 | <0.0001 | ||
PA2004 trend change | -120,338 | <0.0001 | |||
PA2007 trend change | 194,043 | <0.0001 | |||
CNY | -577,052 | 0.0220 | |||
Renin-angiotensin drugs | Jan 1997 to Dec 2008 | p = (6); | Constant | 3,753,898 | <0.0001 |
q = (6) | Baseline trend | 152,800 | <0.0001 | ||
PA2001 trend change | 110,259 | <0.0001 | |||
PA2004 trend change | -133,325 | <0.0001 | |||
PA2006 level change | -2,224,884 | <0.0001 | |||
PA2007 trend change | 173,056 | <0.0001 | |||
CNY | -1,108,357 | 0.0011 | |||
Subgroup analyses for ACEIs | |||||
Patented ACEIs | Jan 1997 to Dec 2008 | p = (1)(6,12); | Constant | 497,488 | <0.0001 |
q = (1) | Baseline trend | 12,684 | <0.0001 | ||
PA2001 level change | 189,675 | 0.0281 | |||
PA2007 trend change | 25,478 | 0.0088 | |||
CNY | -116,498 | 0.0011 | |||
Off-patent ACEIs | Jan 1997 to Dec 2008 | p = (1)(12); | Constant | 3,987,107 | <0.0001 |
q = (1)(9) | Baseline trend | 45,221 | <0.0001 | ||
PA2000 level change | -380,037 | 0.0251 | |||
PA2003 level change | -1,022,868 | <0.0001 | |||
PA2004 trend change | -70,970 | <0.0001 | |||
PA2006 level change | -1,675,618 | <0.0001 | |||
PA2007 level change | -689,097 | 0.0002 | |||
CNY | -239,858 | 0.0034 | |||
Off-patent original branded ACEIs | Jan 1997 to Dec 2008 | p = (1)(12); | Constant | 3,195,426 | <0.0001 |
q = (1)(9) | Baseline trend | 12,121 | 0.0081 | ||
PA2000 level change | -266,177 | 0.0271 | |||
PA2003 level change | -498,038 | <0.0001 | |||
PA2004 trend change | -46,182 | <0.0001 | |||
PA2006 level change | -575,144 | <0.0001 | |||
CNY | -182,498 | 0.0019 | |||
Off-patent generic ACEIs | Jan 1997 to Dec 2008 | p = (1)(12); | Constant | 985,881 | 0.0269 |
q = (1)(5,9) | Baseline trend | 27,153 | 0.0008 | ||
PA2003 level change | -525,353 | <0.0001 | |||
PA2006 level change | -1,092,328 | <0.0001 | |||
PA2007 level change | -524,951 | <0.0001 |