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Table 4 Power calculations for main outcomes in the ADDITION-PRO study

From: Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care

  Expected CVD events (n) Expected incidence rate (per 1000 person years) Power
Difference in CVD incidence between:    
  NGT and stable IFG/IGT 53 7.4 0.97
  NGT and incident DM 100 13.8 0.99
  Stable IFG/IGT and incident diabetes 132 18.3 0.59
  Detectable differences Expected mean (SD) in reference group (NGT) Power
Aortic stiffness (pulse wave velocity) 0.4 m/s 7.5 m/s (2.5) 0.94
Renal function (eGFR) 5 ml/min/1.73 m2 100 ml/min/1.73 m2 (20) 0.98
AGE – (skin autofluorescence) 0.2 AU 2.0 AU (0.5) 0.94
  1. AGE = advanced glycation end-products; CVD = cardiovascular disease;
  2. eGFR = estimated glomerular filtration rate; IFG = impaired fasting glucose;
  3. IGT = impaired glucose tolerance; NGT = normal glucose tolerance.