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Table 3 Quality assessment of studies of multiple micronutrients supplementation during pregnancy to prevent stillbirths:

From: The effect of folic acid, protein energy and multiple micronutrient supplements in pregnancy on stillbirths

Quality Assessment

Directness

Summary of findings

No. of studies (Ref)

Design

Limitations

Consistency

Generalizability to Population of Interest

Generalizability to intervention of Interest

Relative Risk ( 95 % CI)

Stillbirth: Low outcome specific quality

13

RCT

Methods of sequence generation and allocation concealment were not explicitly described in few of the studies

Heterogeneity in the pooled data was not significant (I2=38%)

All included studies from developing countries

Nine studies used UNIMMAP formulation (30 mg iron, 400 µg folic acid, 15 mg zinc, 2 mg copper, 65 µg selenium, 800 µg RE vitamin A, 1.4 mg vitamin B1, 1.4 mg vitamin B2, 18 mg niacin, 1.9 mg vitamin B6, 2.6 µg vitamin B12, 70 mg vitamin C, 5 µg vitamin D, 10 mg vitamin E and 150 µg iodine)

0.98 (0.88-1.10)a

Peri-natal mortality: Low outcome specific quality

11

RCT

Methods of sequence generation and allocation concealment were not explicitly described in few of the studies

Significant heterogeneity (I2=56%). Random models used

All included studies from developing countries

Nine studies used UNIMMAP formulation (30 mg iron, 400 µg folic acid, 15 mg zinc, 2 mg copper, 65 µg selenium, 800 µg RE vitamin A, 1.4 mg vitamin B1, 1.4 mg vitamin B2, 18 mg niacin, 1.9 mg vitamin B6, 2.6 µg vitamin B12, 70 mg vitamin C, 5 µg vitamin D, 10 mg vitamin E and 150 µg iodine)

1.07 (0.92 –1.25)a

  1. a: generic inverse variance